Integrative Biomedical Research (Former Journal of Angiotherapy)
Integrative Biomedical Research | Online ISSN  2207-872X
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Contents Vol 8 (5)

Urosepsis: Bridging Urological Infection and Systemic Crisis Through Rapid Intervention and Multidisciplinary Care

Ghadeer Hemaidan Altalhi 1*, Albatole Ali Gorban 1, Ohud Hadyan Albaqami 1, Zainab Ali Alqarni 1, Alaa Musaad Alsayyari 1, Hessah Ahmed Alqadeeb 1, Wasan Mohammed Alshikhi 1, Mohammed Ahmed  Hadadi 1, Wadha Siar Al-anazi 1, Fahad  Ayidh  Al Qarn 1, Braik  Dafer Al Qarni 1, Hind Saad Mohammed Al Areefi 1, Manhal  Ali Abdul Rahman Al Quraishi 1, Fahdah Mehsan Alotaibi 1, Fatimah Abdullah Alammar 1, Khalid Ali Al Mazirai 1

+ Author Affiliations

Integrative Biomedical Research (Former Journal of Angiotherapy) 8 (5) 1-8 https://doi.org/10.25163/angiotherapy.8510285

Submitted: 31 March 2024 Revised: 03 May 2024  Published: 05 May 2024 

Abstract

Background: Urosepsis is a life-threatening systemic response to urogenital tract infections, characterized by dysregulated host immune responses leading to multi-organ dysfunction. Despite advances in critical care, it remains a significant cause of mortality, with rising antimicrobial resistance complicating management. Aim: This review synthesizes current evidence on urosepsis etiology, pathophysiology, diagnosis, and management to guide clinical practice and improve patient outcomes.Methods: A comprehensive literature analysis was conducted, focusing on epidemiology, microbial etiology, diagnostic approaches (clinical, laboratory, and imaging), and evidence-based treatment strategies, including antimicrobial stewardship and multidisciplinary care. Results: Urosepsis mortality remains high (30–40%), with outcomes dependent on timely intervention. Escherichia coli (50%) dominates etiology, but multidrug-resistant pathogens are increasing. Early goal-directed therapy (antibiotics within 1 hour, fluid resuscitation, and source control) reduces mortality. CT imaging outperforms ultrasound for obstruction detection (93% sensitivity). Long-term sequelae include chronic kidney disease (30–40% of survivors). Conclusion: A multidisciplinary approach—integrating rapid diagnostics, tailored antibiotics, and source control—is critical. Patient education and antimicrobial stewardship are essential for prevention.

Keywords: urosepsis, urinary tract infection, sepsis management, antimicrobial resistance, multidisciplinary care

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