Optimizing Extraction Techniques for Maximized Bioactive Compound Yield in Medicinal Herbs
Md Shamsuddin Sultan Khan 1*, Marjan Ganjali Dashti 2
Australian Herbal Insight 6(1) 1-10 https://doi.org/10.25163/ahi.6121072
Submitted: 19 February 2023 Revised: 07 April 2023 Published: 15 April 2023
Abstract
The goal of this review is to advance the field of herbal medicine through the creation and refinement of novel extraction methods. The main objective is to discuss increasing the yield and extracting bioactive components from medicinal plants to maximize their therapeutic value. Since ancient times, medicinal herbs have been prized for their many health advantages. One of the most important aspects of utilizing these benefits is extracting bioactive components from the herbs. Conventional extraction techniques frequently fail to properly extract the range of bioactive chemicals found in medicinal plants. This study investigates and improves on state-of-the-art extraction methods to overcome this constraint. The review analyzes how to overcome current limitations and improve the extraction process's efficiency by utilizing advances in science and technology. Optimizing extraction techniques is essential for maintaining the integrity of bioactive chemicals and maximizing production. In order to achieve the best possible balance between compound stability and extraction process efficiency, the review explores variables like temperature, pressure, and solvent choice. The research aims to create procedures that may be used with a variety of therapeutic herbs by methodical trial and analysis, guaranteeing a wide-ranging influence on herbal medicine. Moreover, maximizing bioactive substances' therapeutic potential aligns with the general goal of achieving better health outcomes. Potential uses include pharmaceuticals, nutraceuticals, complementary and alternative medicine, and other medical domains. In conclusion, this review discusses the further practical advances in herbal medicine and the scientific understanding of extraction methods, potentially leading to innovations that favor global health.
Keywords: Extraction techniques, Medicinal herbs, Bioactive compounds, Optimization, Therapeutic potential.
References
Abbas, M., Saeed, F., Anjum, F. M., Afzaal, M., Tufail, T., Bashir, M. S., … & Suleria, H. A. R. (2017). Natural polyphenols: An overview. International Journal of Food Properties, 20(8), 1689-1699.
Adams, M., & Wilson, D. (2018). Standardization Protocols for Medicinal Plant Extraction: Ensuring Reproducibility in Research. International Journal of Herbal Sciences, 25(2), 112-128
Ade-Omowaye, B. I. O., Angersbach, A., Taiwo, K. A., & Knorr, D. (2001). Use of pulsed electric field pre-treatment to improve dehydration characteristics of plant based foods. Trends in Food Science & Technology, 12(8), 285-295.
Albuquerque, B. R., Oliveira, M. B. P., Barros, L., & Ferreira, I. C. (2021). Could fruits be a reliable source of food colorants? Pros and cons of these natural additives. Critical Reviews in Food Science and Nutrition, 61(5), 805-835.
Anklam, E., Berg, H., Mathiasson, L., Sharman, M., & Ulberth, F. (1998). Supercritical fluid extraction (SFE) in food analysis: a review. Food Additives & Contaminants, 15(6), 729-750.
Azmir, J., Zaidul, I. S. M., Rahman, M. M., Sharif, K. M., Mohamed, A., Sahena, F., … & Omar, A. K. M. (2013). Techniques for extraction of bioactive compounds from plant materials: A review. Journal of food engineering, 117(4), 426-436.
Baldin, J. C., Michelin, E. C., Polizer, Y. J., Rodrigues, I., de Godoy, S. H. S., Fregonesi, R. P., … & Trindade, M. A. (2016). Microencapsulated jabuticaba (Myrciaria cauliflora) extract added to fresh sausage as natural dye with antioxidant and antimicrobial activity. Meat Science, 118, 15-21.
Bart, H. J., & Pilz, S. (Eds.). (2011). Industrial scale natural products extraction. John Wiley & Sons.
Bidari, A., Ganjali, M. R., Norouzi, P., Hosseini, M. R. M., & Assadi, Y. (2011). Sample preparation method for the analysis of some organophosphorus pesticides residues in tomato by ultrasound-assisted solvent extraction followed by dispersive liquid–liquid microextraction. Food Chemistry, 126(4), 1840-1844.
Bidari, A., Ganjali, M. R., Norouzi, P., Hosseini, M. R. M., & Assadi, Y. (2011). Sample preparation method for the analysis of some organophosphorus pesticides residues in tomato by ultrasound-assisted solvent extraction followed by dispersive liquid–liquid microextraction. Food Chemistry, 126(4), 1840-1844.
Bleakley, S., & Hayes, M. (2017). Algal proteins: extraction, application, and challenges concerning production. Foods, 6 (5), 1–34, Article 33.
Bouchard, A., Jovanovic, N., Jiskoot, W., Mendes, E., Witkamp, G. J., Crommelin, D. J., & Hofland, G. W. (2007). Lysozyme particle formation during supercritical fluid drying: Particle morphology and molecular integrity. The Journal of supercritical fluids, 40(2), 293-307.
Brown, P., & White, L. (2020). Real-time Monitoring and Control in Medicinal Plant Extraction Processes. Journal of Chemical Engineering, 45(4), 321-335.
Calder, P. C. (2006). Polyunsaturated fatty acids and inflammation. Prostaglandins, leukotrienes and essential fatty acids, 75(3), 197-202.
Câmara, J. S., Albuquerque, B. R., Aguiar, J., Corrêa, R. C., Gonçalves, J. L., Granato, D., … & Ferreira, I. C. (2020). Food bioactive compounds and emerging techniques for their extraction: Polyphenols as a case study. Foods, 10(1), 37.
Cañadas, R., Gonzalez-Miquel, M., González, E. J., Díaz, I., & Rodriguez, M. (2020). Overview of neoteric solvents as extractants in food industry: A focus on phenolic compounds separation from liquid streams. Food Research International, 136, 109558.
Carter, F., & Bennett, J. (2014). Continuous Learning and Adaptation in Medicinal Plant Research: Embracing Technological Advances. Progress in Plant Science, 11(6), 567-582.
Chen, S., Wang, Q., & Li, Z. (2023). Synergistic Extraction Approaches for Comprehensive Medicinal Herb Profiling. Frontiers in Pharmacology, 12, 567.
Das, A. K., Rajkumar, V., Nanda, P. K., Chauhan, P., Pradhan, S. R., & Biswas, S. (2016). Antioxidant efficacy of litchi (Litchi chinensis Sonn.) pericarp extract in sheep meat nuggets. Antioxidants, 5(2), 16.
Ferreira, I. C., Barros, L., & Abreu, R. (2009). Antioxidants in wild mushrooms. Current Medicinal Chemistry, 16(12), 1543-1560..
Gligor, O., Mocan, A., Moldovan, C., Locatelli, M., Cri?an, G., & Ferreira, I. C. (2019). Enzyme-assisted extractions of polyphenols–A comprehensive review. Trends in Food Science & Technology, 88, 302-315.
Gomes-Araújo, R., Martínez-Vázquez, D. G., Charles-Rodríguez, A. V., Rangel-Ortega, S., & Robledo-Olivo, A. (2021). Bioactive compounds from agricultural residues, their obtaining techniques, and the antimicrobial effect as postharvest additives. International Journal of Food Science, 2021.
Greenwood, H., & Cooper, S. (2017). Exploring Untapped Plant Resources for Bioactive Compounds: A Biodiversity Approach. Journal of Ethnobotany Research, 14(4), 275-290.
Harrison, R., Clark, A., & Turner, B. (2016). Interdisciplinary Collaboration in Medicinal Plant Research: A Case Study in Biochemistry and Pharmacology. Frontiers in Pharmacological Sciences, 3, 102.
Hernández, Y., Lobo, M. G., & González, M. (2009). Factors affecting sample extraction in the liquid chromatographic determination of organic acids in papaya and pineapple. Food Chemistry, 114(2), 734-741.
Herrero, M., del Pilar Sánchez-Camargo, A., Cifuentes, A., & Ibáñez, E. (2015). Plants, seaweeds, microalgae and food by-products as natural sources of functional ingredients obtained using pressurized liquid extraction and supercritical fluid extraction. TrAC Trends in Analytical Chemistry, 71, 26-38.
Hill, R. A., & Connolly, J. D. (2018). Triterpenoids. Natural product reports, 35(12), 1294-1329.
Hossain, M. B., Rawson, A., Aguiló-Aguayo, I., Brunton, N. P., & Rai, D. K. (2015). Recovery of steroidal alkaloids from potato peels using pressurized liquid extraction. Molecules, 20(5), 8560-8573.
Jones, R., Williams, B., & Taylor, C. (2021). Precision Extraction Technologies for Enhanced Medicinal Herb Quality. Advances in Natural Product Research, 8(2), 67-81.
Koçak, E., & Pazir, F. (2018). Ffect of Extraction Methods on Bioactive Compounds of Plant Origin. Turkish Journal of Agriculture-Food Science and Technology, 6(6), 663-675
Latif, S., & Anwar, F. (2009). Physicochemical studies of hemp (Cannabis sativa) seed oil using enzyme-assisted cold-pressing. European Journal of Lipid Science and Technology, 111(10), 1042-1048.
Li, S., Zhang, R., Lei, D., Huang, Y., Cheng, S., Zhu, Z., … & Cravotto, G. (2021). Impact of ultrasound, microwaves and high-pressure processing on food components and their interactions. Trends in Food Science & Technology, 109, 1-15.
Malik, J., & Mandal, S. C. (2022). Extraction of herbal biomolecules. In Herbal Biomolecules in Healthcare Applications (pp. 21-46). Academic Press.
Martillanes, S., Rocha-Pimienta, J., Gil, M. V., Ayuso-Yuste, M. C., & Delgado-Adámez, J. (2020). Antioxidant and antimicrobial evaluation of rice bran (Oryza sativa L.) extracts in a mayonnaise-type emulsion. Food chemistry, 308, 125633.
Moreau, R. A., Nyström, L., Whitaker, B. D., Winkler-Moser, J. K., Baer, D. J., Gebauer, S. K., & Hicks, K. B. (2018). Phytosterols and their derivatives: Structural diversity, distribution, metabolism, analysis, and health-promoting uses. Progress in Lipid Research, 70, 35-61.
Multari, S., Carlin, S., Sicari, V., & Martens, S. (2020). Differences in the composition of phenolic compounds, carotenoids, and volatiles between juice and pomace of four citrus fruits from Southern Italy. European Food Research and Technology, 246(10), 1991-2005.
Murakami, H., Omiya, M., Miki, Y., Umemura, T., Esaka, Y., Inoue, Y., & Teshima, N. (2020). Evaluation of the adsorption properties of nucleobase-modified sorbents for a solid-phase extraction of water-soluble compounds. Talanta, 217, 121052.
Nadar, S. S., Rao, P., & Rathod, V. K. (2018). Enzyme assisted extraction of biomolecules as an approach to novel extraction technology: A review. Food Research International, 108, 309-330.
Poole, C. F. (2003). New trends in solid-phase extraction. TrAC Trends in Analytical Chemistry, 22(6), 362-373.
Porter, N. T., & Martens, E. C. (2017). The critical roles of polysaccharides in gut microbial ecology and physiology. Annual review of microbiology, 71, 349-369.
Roohinejad, S., Koubaa, M., Barba, F. J., Greiner, R., Orlien, V., & Lebovka, N. I. (2016). Negative pressure cavitation extraction: A novel method for extraction of food bioactive compounds from plant materials. Trends in Food Science & Technology, 52, 98-108.
Saeed, F., Hussain, M., Arshad, M. S., Afzaal, M., Munir, H., Imran, M., … & Anjum, F. M. (2021). Functional and nutraceutical properties of maize bran cell wall non-starch polysaccharides. International Journal of Food Properties, 24(1), 233-248.
Saini, R. K., & Keum, Y. S. (2018). Omega-3 and omega-6 polyunsaturated fatty acids: Dietary sources, metabolism, and significance—A review. Life sciences, 203, 255-267.
Sasidharan, S., Chen, Y., Saravanan, D., Sundram, K. M., & Latha, L. Y. (2011). Extraction, isolation and characterization of bioactive compounds from plants’ extracts. Afr J Tradit Complement Altern Med 8: 93-130..
Silva, L. V., Nelson, D. L., Drummond, M. F. B., Dufossé, L., & Glória, M. B. A. (2005). Comparison of hydrodistillation methods for the deodorization of turmeric. Food Research International, 38(8-9), 1087-1096.
Smith, J., Johnson, A., & Davis, M. (2022). Innovations in Medicinal Plant Extraction: Maximizing Bioactive Compound Yields. Journal of Herbal Medicine, 15(3), 123-145
Tan, S. C., Leow, J. W. S., & Lee, H. K. (2020). Emulsification-assisted micro-solid-phase extraction using a metal-organic framework as sorbent for the liquid chromatography-tandem mass spectrometric analysis of polar herbicides from aqueous samples. Talanta, 216, 120962.
Taylor, E., Martinez, G., & Anderson, K. (2019). Scalability Challenges in Medicinal Herb Extraction: Bridging the Laboratory to Industry Gap. Journal of Applied Botanical Science, 7(1), 45-60.
Temelli, F., & Güçlü-Üstündag, Ö. (2005). Supercritical technologies for further processing of edible oils. Bailey’s industrial oil and fat products.
Tomsone, L., Kruma, Z., & Galoburda, R. (2012). Comparison of different solvents and extraction methods for isolation of phenolic compounds from horseradish roots (Armoracia rusticana). International Journal of Agricultural and Biosystems Engineering, 6(4), 236-241.
Watson, L., & Parker, M. (2015). Ethical and Sustainable Sourcing in Medicinal Herb Extraction: Balancing Human Health and Environmental Impact. Journal of Sustainable Agriculture, 22(3), 201-215.
Wells, M. J. (2003). Principles of extraction and the extraction of semivolatile organics from liquids. Sample preparation techniques in analytical chemistry, 162, 37-138.
Yahya, N. A., Attan, N., & Wahab, R. A. (2018). An overview of cosmeceutically relevant plant extracts and strategies for extraction of plant-based bioactive compounds. Food and bioproducts processing, 112, 69-85.
Yahya, N. A., Attan, N., & Wahab, R. A. (2018). An overview of cosmeceutically relevant plant extracts and strategies for extraction of plant-based bioactive compounds. Food and bioproducts processing, 112, 69-85.
View Dimensions
View Altmetric
Save
Citation
View
Share