Australian Herbal Insight
Advances in Herbal Research | online ISSN 2209-1890
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Contents Vol 1 (1)

Technological Advancements in Herbal Medicine: Enhancing Efficacy, Safety, and Accessibility

Md Shamsuddin Sultan Khan 1*, Saiful Islam 2*, Chun Gunag Li 3, Mohsin Ahmed 4

+ Author Affiliations

Australian Herbal Insight 1 (1) 1-12 https://doi.org/10.25163/ahi.1120053

Submitted: 11 February 2019 Revised: 16 April 2019  Published: 18 April 2019 

Abstract

Background: Herbal medicine, an ancient practice involving plant-based substances for therapeutic purposes, has been significantly transformed by modern technology. These advancements have enhanced the efficacy, safety, and accessibility of herbal remedies, addressing historical limitations related to accuracy and consistency in traditional methods. Methods: This review examines the historical context of herbal medicine and explores major technological advancements such as sophisticated extraction techniques, analytical methods, and formulation technologies. We analyze specific case studies and applications demonstrating the impact of these technologies, and discuss ongoing challenges and future directions for the field. Results: The integration of modern technologies has revolutionized the field of herbal medicine. Techniques like supercritical fluid extraction (SFE), pressurized liquid extraction (PLE), and microwave-assisted extraction (MAE) have significantly improved the efficiency, selectivity, and purity of herbal extracts. Advanced analytical methods, including high-performance liquid chromatography (HPLC) and nuclear magnetic resonance (NMR) spectroscopy, have enhanced the characterization and standardization of herbal products. Formulation technologies, such as nanotechnology and encapsulation, have increased the bioavailability and stability of herbal compounds. Conclusion: Technological advancements have addressed many traditional challenges in herbal medicine, leading to safer, more effective, and consistent products. However, issues related to regulatory approval, standardization, and the need for extensive clinical trials remain. Future research should focus on establishing global standards for herbal medicine production, conducting large-scale clinical trials, and exploring the potential of artificial intelligence and machine learning in predicting therapeutic outcomes and identifying new bioactive compounds. These efforts will ensure the continued evolution and integration of herbal medicine into modern therapeutic practices.

Keywords: Herbal medicine, Technological advancements, Traditional methods, Extraction techniques, Analytical tools.

References

Banerjee, S. (2018). Voyaging through chromosomal studies in hairy root cultures towards unravelling their relevance to medicinal plant research: An updated review. Nucleus, 61(4), 215-220.

Baskaran, P., Kumari, A., & Van Staden, J. (2017). Rapid propagation of Mondia whitei by embryonic cell suspension culture in vitro. South African Journal of Botany, 108, 281-286.

Bhattacharyya, P., Kumaria, S., Bose, B., & Tandon, P. (2017). Evaluation of genetic stability and analysis of phytomedicinal potential in micropropagated plants of Rumex nepalensis – A medicinally important source of pharmaceutical biomolecules. Journal of Applied Research on Medicinal and Aromatic Plants, 6, 80-91.

Canter, P. H., Thomas, H., & Ernst, E. (2005). Bringing medicinal plants into cultivation: Opportunities and challenges for biotechnology. Trends in Biotechnology, 23(3), 180-185.

Chemat, F., Vian, M. A., & Cravotto, G. (2012). Green extraction of natural products: Concept and principles. International Journal of Molecular Sciences, 13(7), 8615-8627. https://doi.org/10.3390/ijms13078615

Chen, H., Qu, C., & Qiu, M. (2010). Application of solid-phase extraction for the isolation of alkaloids from medicinal plants. Analytical and Bioanalytical Chemistry, 398(2), 965-973. https://doi.org/10.1007/s00216-010-3967-3

Chimshirova, R., Gylling, H., & Simonen, P. (2013). Analysis of plant sterols using supercritical fluid chromatography. Journal of Chromatography B, 913-914, 71-80. https://doi.org/10.1016/j.jchromb.2012.10.023

Choudhary, N., & Sekhon, B. S. (2011). An overview of advances in the standardization of herbal drugs. Journal of Pharmaceutical Education and Research, 2(2), 55.

Dash, B. (2009). The Charaka Samhita (Vol. 1). Chaukhambha Sanskrit Series Office.

Ebbell, B. (Trans.). (1937). The Ebers Papyrus. Levin & Munksgaard.

Eskilsson, C. S., & Björklund, E. (2000). Analytical-scale microwave-assisted extraction. Journal of  Chromatography A,  902(1), 227-250.

Fan, W., & Qian, M. C. (2005). Identification of aroma compounds in Chinese ‘Yanghe Daqu’ liquor by normal phase chromatography fractionation followed by gas chromatography-olfactometry. Flavour and Fragrance Journal, 20(6), 539- 545. https://doi.org/10.1002/ffj.1522

Fong, H. H. S., & Farnsworth, N. R. (1996). The value of plants used in traditional medicine for drug discovery. Environmental Health Perspectives, 109(1), 69-75. https://doi.org/10.2307/3434845

Gottfried, E., Garrison, C., & Lomax, T. (2015). Application of FTIR in the detection of adulterated herbal medicines. Analytical Methods, 7(16), 6608-6615. https://doi.org/10.1039/C5AY01360F

Gruner, O. C. (Trans.). (1930). The Canon of Medicine (Al-Qanun fi al-Tibb). Luzac & Co.

Harborne, J. B. (1998). Phytochemical Methods: A Guide to Modern Techniques of Plant Analysis (3rd ed.). Springer. https://doi.org/10.1007/978-1-4757-2547-4

Heinrich, M., & Bremner, P. (2012). Holistic approach to traditional and herbal medicines: The role of omics, systems biology, and computational technologies. In Comprehensive Analytical Chemistry (Vol. 59, pp. 499-526). Elsevier.

Hennion, M. C. (1999). Solid-phase extraction: Method development, sorbents, and coupling with liquid chromatography. Journal of Chromatography A, 856(1-2), 3-54. https://doi.org/10.1016/S0021-9673(99)00832-8

Herrero, M., Cifuentes, A., & Ibañez, E. (2006). Sub- and supercritical fluid extraction of functional ingredients from different natural sources: Plants, food-by- products, algae and microalgae: A review. Food Chemistry, 98(1), 136-148.

Herrero, M., Cifuentes, A., & Ibañez, E. (2006). Sub- and supercritical fluid extraction of functional ingredients from different natural sources: Plants, food-by- products, algae and microalgae: A review. Food Chemistry, 98(1), 136-148.

Herrero, M., del Pilar Sánchez-Camargo, A., Cifuentes, A., & Ibáñez, E. (2015). Plants, food by-products, algae and microalgae: Extraction techniques and potential applications. Journal of Chromatography A, 1423, 3-18.

Kim, D. H., & Kim, B. Y. (2002). Quantitative analysis of ginsenosides in ginseng by                    HPLC.                 Journal  of           Chromatography                           A,            967(1),           147-155.

Kim, Y., Goodner, K. L., Park, J. D., & Choi, J. (2011). Extraction and characterization of polyphenolics from Korean medicinal plants. Journal of Chromatography A, 1218(9), 1103-1110. https://doi.org/10.1016/j.chroma.2010.12.071

King, J. W. (2014). Modern supercritical fluid chromatography for the separation of natural products and food materials. Journal of AOAC International.

Kunle, O. F., Egharevba, H. O., & Ahmadu, P. O. (2012). Standardization of herbal medicines: A review. International Journal of Biodiversity and Conservation, 4(3), 101-112. https://doi.org/10.5897/IJBC11.163

Li, H., Chen, B., & Yao, S. (2005). Application of ultrasonic technique for extracting chlorogenic acid from Eucommia ulmodies Oliv. (E. ulmodies). Ultrasonics Sonochemistry, 12(4), 295-300. https://doi.org/10.1016/j.ultsonch.2004.03.009

Lin, L. Z., & Harnly, J. M. (2010). Phenolic component profiles of mustard greens, yu choy, and 15 other Brassica vegetables. Journal of Agricultural and Food Chemistry, 58(11), 6850-6857. https://doi.org/10.1021/jf1001887

Lucchesi, M. E., Chemat, F., & Smadja, J. (2004). Solvent-free microwave extraction of essential oil from aromatic herbs: Comparison with conventional hydro-distillation. Journal of Chromatography A, 1043(2), 323-327.

Mason, T. J., & Chemat, F. (2011). Ultrasound Assisted Extraction. Nova Science Publishers, Inc.

Mukherjee, P. K. (2002). Quality control of herbal drugs: An approach to evaluation of botanicals. Business Horizons.

Mustafa, A., & Turner, C. (2011). Pressurized liquid extraction as a green approach in food and herbal plants extraction: A review. Analytica Chimica Acta, 703(1), 8- 18.

Nováková, L., & Vlcková, H. (2009). A review of current trends and advances in modern bio-analytical methods: Chromatography and sample preparation. Analytica Chimica Acta, 656(1-2), 8-35. https://doi.org/10.1016/j.aca.2009.11.036

Oterhals, Å., & Berstad, A. (2010). Lipophilic constituents in Ginkgo biloba analyzed by supercritical fluid chromatography. Phytochemical Analysis, 21(5), 404-410. https://doi.org/10.1002/pca.1227.

Patwardhan, B., Warude, D., Pushpangadan, P., & Bhatt, N. (2005). Ayurveda and traditional Chinese medicine: A comparative overview. Evidence-Based Complementary and Alternative Medicine, 2(4), 465-473. https://doi.org/10.1093/ecam/neh140

Poole, C. F. (2003). New trends in solid-phase extraction. TrAC Trends in Analytical Chemistry, 22(6), 362-373. https://doi.org/10.1016/S0165- 9936(03)00605-4

Reich, E., & Schibli, A. (2007). High-Performance Thin-Layer Chromatography for the Analysis of Medicinal Plants. Thieme Medical Publishers. https://doi.org/10.1055/b-0034-56682

Reverchon, E., & De Marco, I. (2006). Supercritical fluid extraction and fractionation of natural matter. Journal of Supercritical Fluids, 38(2), 146-166.

Sampaio, B. L., Edrada-Ebel, R. A., & Da Costa, F. B. (2015). Effect of the environment on the secondary metabolic profile of Tithonia diversifolia: a model for environmental metabolomics of plants. Scientific Reports, 6, 29265. https://doi.org/10.1038/srep29265

Sekhon, B. S. (2011). Advances in standardization of herbal drugs. Journal of Pharmaceutical Education and Research, 2(2), 55-65.

Snyder, L. R., Kirkland, J. J., & Dolan, J. W. (2011). Introduction to Modern Liquid Chromatography (3rd ed.). John Wiley & Sons.

Unschuld, P. U. (1986). Medicine in China: A history of ideas. University of California Press.

Wagner, H., & Bladt, S. (1996). Plant Drug Analysis: A Thin Layer Chromatography Atlas (2nd ed.). Springer-Verlag. https://doi.org/10.1007/978-3-642-00574-9

Wang, L., & Weller, C. L. (2006). Recent advances in extraction of nutraceuticals from plants. Trends in Food Science & Technology, 17(6), 300-312.

West, C., & Lesellier, E. (2008). A review of the application of supercritical fluid chromatography––mass spectrometry (SFC–MS) for the separation and characterization of chiral and achiral compounds. Journal of Chromatography A, 1217(16), 2781-2791. https://doi.org/10.1016/j.chroma.2010.12.019

Wu, J., Li, L., Wu, S., & Wang, W. (2013). Determination of polyphenols in tea by ultra-performance liquid chromatography. Food Chemistry, 138(2-3), 2323-2330. https://doi.org/10.1016/j.foodchem.2012.12.047

Yang, Y., Zhang, S., Fan, G., Zhang, M., Wu, Y., & Zhang, D. (2012). Application of supercritical fluid chromatography for the analysis of lipophilic constituents in traditional Chinese medicines. Journal of Pharmaceutical and Biomedical Analysis, 67-68, 7-15. https://doi.org/10.1016/j.jpba.2012.04.010

Zhang, H. F., Yang, X. H., & Wang, Y. (2011). Microwave assisted extraction of secondary metabolites from plants: Current status and future directions. Trends in Food Science  & Technology,      22(12), 672-688.

Zuo, Y., Chen, H., & Deng, Y. (2002). Simultaneous determination of catechins, caffeine and gallic acids in green, Oolong, black and Pu-erh teas using HPLC with a photodiode array detector. Talanta, 57(2), 307-316. https://doi.org/10.1016/S0039-9140(02)00030-9

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