Challenges of Breast Cancer Treatment through Microbial Therapeutic Delivery
Md Shamsuddin Sultan Khan1*, Samia Haque2, Md. Fakruddin2
Microbial Bioactives 6(1) 1-15 https://doi.org/10.25163/microbioactives.619347
Submitted: 09 September 2023 Revised: 18 October 2023 Published: 21 October 2023
Abstract
Breast cancer remains a significant global health concern, necessitating innovative approaches for its treatment. Using bacteria as vehicles for therapeutic delivery has emerged as a promising strategy. As a group of prokaryotic microorganisms, bacteria have great potential for use in cancer therapy. Thus, strategies for treating breast cancer need to be continuously refined to achieve a better patient outcome. This manuscript explores the potential of bacterial-based therapies for breast cancer treatment, elucidating the mechanisms underlying their application, safety considerations, and recent advancements. Nevertheless, notable challenges in bacterial-based cancer treatments include potential cytotoxicity, incomplete cancer cell lysis, and the risk of genomic mutations. With an emphasis on engineering bacteria to target and deliver therapeutic agents specifically to tumor sites, this manuscript provides insights into the future of personalized, precise, and effective breast cancer treatment.
Keywords: Breast cancer, Bacteria, Microorganisms, Pharmacology, PK/PD, safety, efficacy
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