Microbial Bioactives
Microbial Bioactives | Online ISSN 2209-2161
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Volume 7 Number 1 2024
REVIEWS (Open Access)
Harnessing Nature’s Arsenal: A Systematic Perspective on Plant Derived Antimicrobial Combinations Against Drug Resistant Pathogens
Seyedeh Fatemeh Jafari 1*, Sajedeh Ghasempour2, Mohsen Naseri 3, Fatemeh Alijaniha 3
Microbial Bioactives 7 (1) 1-8 https://doi.org/10.25163/microbbioacts.7110665
Submitted: 17 October 2024 Revised: 02 December 2024 Accepted: 09 December 2024 Published: 11 December 2024
Abstract
The escalating global threat of antimicrobial resistance (AMR) poses severe challenges to public health, threatening to render common infections and routine medical procedures life-threatening. Conventional single-target antibiotics often fail against multidrug-resistant (MDR) pathogens, necessitating alternative strategies. Plant-derived bioactive compounds offer a diverse chemical arsenal with inherent antimicrobial potential, often functioning through complex synergistic, additive, or antagonistic interactions. Systematic studies and meta-analyses indicate that combinatorial approaches—pairing phytochemicals with each other or with conventional antibiotics—can enhance antimicrobial efficacy, reduce required dosages, and limit the emergence of resistance. Key mechanisms include membrane disruption, enzyme inhibition, interference with nucleic acid synthesis, and efflux pump modulation. Synergistic combinations are particularly promising, as they exploit multi-targeted attacks that pathogens find harder to counter. Advanced analytical tools such as metabolomics, biochemometrics, and computational synergy prediction enable the identification of potent compound combinations from complex plant matrices. In vivo models, including Caenorhabditis elegans, facilitate preclinical evaluation of both efficacy and safety, bridging the gap between in vitro findings and clinical application. While challenges remain—including chemical variability, antagonistic interactions, and limited human trials—systematic evaluation of plant-derived combinations provides a strategic pathway to complement existing antibiotics. Integrating multi-targeted phytochemicals with conventional therapeutics represents a promising avenue in the fight against AMR, offering a sustainable and biologically inspired solution to one of the most pressing global health crises of the 21st century.
Keywords: antimicrobial resistance, plant-derived compounds, synergistic interactions, multidrug-resistant pathogens, natural product combinations
References
Bassolé, I. H. N., & Lamien-Meda, A. (2010). Composition and antimicrobial activities of Lippia multiflora, Mentha x piperita and Ocimum basilicum essential oils alone and in combination. Molecules, 15(11), 7825–7839. https://doi.org/10.3390/molecules15117825
Berenbaum, M. C. (1989). What is synergy? Pharmacological Reviews, 41(2), 93–141. https://pubmed.ncbi.nlm.nih.gov/2692037/
Blaskovich, M. A., Kavanagh, A. M., Elliott, A. G., Zhang, B., Ramu, S., Amado, M., ... & Cooper, M. A. (2021). The antimicrobial potential of cannabidiol. Communications Biology, 4(1), 1–18. https://doi.org/10.1038/s42003-020-01530-y
Caesar, L. K., Kellogg, J. J., Kvalheim, O. M., & Rønsted, N. (2018). Integration of biochemometrics and molecular networking to identify antimicrobials in Angelica keiskei. Planta Medica, 84(09/10), 721–728. https://doi.org/10.1055/a-0590-5233
Cowan, M. M. (1999). Plant products as antimicrobial agents. Clinical Microbiology Reviews, 12(4), 564–582. https://doi.org/10.1128/CMR.12.4.564
Daglia, M. (2012). Polyphenols as antimicrobial agents. Current Opinion in Biotechnology, 23(2), 174–181. https://doi.org/10.1016/j.copbio.2011.08.007
Eloff, J. N. (2004). Quantification of the bioactivity of plant extracts during screening and bioassay-guided fractionation. Phytomedicine, 11(4), 370–371. https://doi.org/10.1078/0944711041495153
Ganora, L. (2009). Herbal Constituents: Foundations of Phytochemistry. https://herbalconstituents.com/
Górniak, I., Bartoszewski, R., & Króliczewski, J. (2019). Comprehensive review of antimicrobial activities of plant flavonoids. Phytochemistry Reviews, 18(1), 241–272. https://doi.org/10.1007/s11101-018-9591-z
Hemaiswarya, S., Kruthiventi, A. K., & Doble, M. (2008). Synergism between natural products and antibiotics against infectious diseases. Phytomedicine, 15(8), 639–652. https://doi.org/10.1016/j.phymed.2008.06.008
Jang, E. J., Cha, S. M., Choi, S. M., & Cha, J. D. (2014). Combination effects of baicalein with antibiotics against oral pathogens. Archives of Oral Biology, 59(11), 1233–1241. https://doi.org/10.1016/j.archoralbio.2014.07.011
Karas, J. A., Wong, L. J., Paulin, O. K., Mazeh, A. C., Hussein, M. H., Li, J., & Velkov, T. (2020). The antimicrobial activity of cannabinoids. Antibiotics, 9(7), 406. https://doi.org/10.3390/antibiotics9070406
Langeveld, W. T., Veldhuizen, E. J., & Burt, S. A. (2014). Synergy between essential oil components and antibiotics: A review. Critical Reviews in Microbiology, 40(1), 76–94. https://doi.org/10.3109/1040841X.2013.763219
Moy, T. I., Ball, A. R., Anklesaria, Z., et al. (2006). Identification of novel antimicrobials using a live-animal infection model. Proceedings of the National Academy of Sciences, 103(27), 10414–10419. https://doi.org/10.1073/pnas.0604055103
Nakabayashi, R., & Saito, K. (2013). Metabolomics for unknown plant metabolites. Analytical and Bioanalytical Chemistry, 405(15), 5005–5011. https://doi.org/10.1007/s00216-013-6868-5
Newman, D. J., & Cragg, G. M. (2016). Natural products as sources of new drugs from 1981 to 2014. Journal of Natural Products, 79(3), 629–661. https://doi.org/10.1021/acs.jnatprod.5b01055
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., … Moher, D. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ, 372, n71. https://doi.org/10.1136/bmj.n71
Rather, M. A., Bhat, B. A., & Qurishi, M. A. (2013). Multicomponent phytotherapeutic approach gaining momentum. Phytomedicine, 21(1), 1–14. https://doi.org/10.1016/j.phymed.2013.08.003
Savoia, D. (2012). Plant-derived antimicrobial compounds: Alternatives to antibiotics. Future Microbiology, 7(8), 979–990. https://doi.org/10.2217/fmb.12.67
Stermitz, F. R., Lorenz, P., Tawara, J. N., Zenewicz, L. A., & Lewis, K. (2000). Synergy in a medicinal plant: Antimicrobial action of berberine potentiated by 5'-methoxyhydnocarpin. Proceedings of the National Academy of Sciences, 97(4), 1433–1437. https://doi.org/10.1073/pnas.97.4.1433
Tang, J., Wennerberg, K., & Aittokallio, T. (2015). What is synergy? Frontiers in Pharmacology, 6, 181. https://doi.org/10.3389/fphar.2015.00181
van Vuuren, S., & Viljoen, A. (2011). Plant-based antimicrobial studies—methods and approaches to study the interaction between natural products. Planta Medica, 77(11), 1168–1182. https://doi.org/10.1055/s-0030-1250736
Vaou, N., Stavropoulou, E., Voidarou, C., Tsakris, Z., Rozos, G., Tsigalou, C., & Bezirtzoglou, E. (2022). Interactions between medical plant-derived bioactive compounds: Focus on antimicrobial combination effects. Antibiotics, 11(8), 1014. https://doi.org/10.3390/antibiotics11081014
Wagner, H., & Ulrich-Merzenich, G. (2009). Synergy research: Approaching a new generation of phytopharmaceuticals. Phytomedicine, 16(2–3), 97–110. https://doi.org/10.1016/j.phymed.2008.12.018
World Health Organization. (2014). Antimicrobial Resistance: Global Report on Surveillance. https://www.who.int/publications/i/item/9789241564748
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