Biomaterials for 3D Printing of Patient-Specific Organ Models
Hilal Ahmad Rather 1*, Jigar Vya 2, Sudarshan Singh 3
Biosensors and Nanotheranostics 2(1) 1-9 https://doi.org/10.25163/biosensors.217333
Submitted: 18 March 2023 Revised: 10 May 2023 Published: 22 May 2023
Abstract
Organ bioprinting represents a transformative approach in regenerative medicine aimed at fabricating functional tissues and organs for transplantation and disease modeling. This review provides an overview of the current state, challenges, and future prospects of organ bioprinting technology. We discuss the principles, techniques, and biomaterials utilized in organ bioprinting, emphasizing the importance of achieving biocompatibility, structural integrity, and functionality in printed constructs. Key advancements, such as multi-material bioprinting, vascularization strategies, and integration with biomanufacturing technologies, are highlighted. Additionally, we explore the role of artificial intelligence and computational modeling in optimizing bioprinting processes and designing patient-specific constructs. Regulatory and ethical considerations, along with case studies of successful organ printing, are examined to contextualize the clinical translation of bioprinted organs. Finally, future perspectives and emerging trends in organ bioprinting, including organ-on-a-chip platforms and AI-driven computational modeling, are discussed. Overall, this review underscores the transformative potential of organ bioprinting in advancing regenerative medicine and personalized healthcare.
Keywords: 3D Printing, Patient-Specific Organ Models, Biomaterials, Synthetic Polymers, Natural Biomaterials
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