Advances in Herbal Research | online ISSN 2209-1890
REVIEWS   (Open Access)

In-depth Phytochemical Analysis of Herbs from the Region to Identify Key Compounds with Medicinal Properties and Understand their Mechanisms of Action

Maryam Abbasi 1*, Mansoureh Nazari Vishkaei 2

+ Author Affiliations

Australian Herbal Insight 5(1) 1-18 https://doi.org/10.25163/ahi.5121067

Submitted: 01 December 2021  Revised: 03 January 2022  Published: 24 January 2022 

Abstract

The area of phytochemical analysis, which sits at the nexus of botany, chemistry, and medicine, is vital and active and sheds insight on the mostly untapped medicinal potential of local herbs. Our world is home to a remarkable variety of plant species, many of which have been traditionally used for their medicinal benefits in diverse civilizations. Although these tried-and-true treatments have had a big impact on human health and wellbeing, their full therapeutic potential is still mostly unrealized. This abstract explores the significant significance of phytochemical analysis, which aims to identify the chemical constituents in charge of these local herbs' therapeutic capabilities. We can unravel the mysteries of these herbs' therapeutic properties by examining the variety of chemical components that make them up. Alkaloids, flavonoids, terpenoids, and polyphenols are examples of phytochemicals that have been demonstrated to exhibit a variety of biological functions, such as antioxidant, anti-inflammatory, antibacterial, and anticancer characteristics. We can recognize and use these chemicals for therapeutic purposes by comprehend the complex biochemical composition of local plants. This study's ramifications go far beyond the confines of the lab. New medications, herbal supplements, and complementary therapies may be created as a result of the identification of novel chemicals and their therapeutic potential in local herbs. Additionally, it provides access to affordable and long-lasting healthcare treatments, particularly in areas with limited access to contemporary medicine. In addition to deepening our understanding of the richness of the natural world, this frontier has the potential to completely transform the healthcare sector by introducing new methods for illness prevention and holistic well-being. Phytochemical analysis is a ray of hope in a world that is changing quickly and where there is a growing need for sustainable and natural treatments. It provides a link between age-old knowledge and modern science. This abstract emphasizes the immense potential that lies within our botanical heritage, waiting to be harnessed for the benefit of human health and our planet’s future.

Keywords:  Phytochemical Analysis,  Medicinal Potential,  Regional Herbs,. Botanical Heritage

References

Aebersold, R., and Mann, M. (2003). Mass spectrometry-based proteomics. Nature, 422(6928), 198-207.

Ahmad I, Aqil F, Owais M. Modern phytomedicine: Turning medicinal plants into drugs: John Wiley & Sons; 2006.

Akram M. Curcuma Longa and curcumin: a review. Rom. J. Biol. Plant Biol. Bucharest, 2010;55(2):65–70

and antioxidant capacity of different Echinacea species. J Pharm Pharmacol 2001; 53(6): 849-57

Bhawani, S. A., Sulaiman, O., Hashim, R., & Ibrahim, M. N. (2011). Thin-Layer Chromatographic Analysis of Steroids. Tropical Journal of Pharmaceutical Research, 9(3), 301–313.

Bora KS and Sharma A (2011). The genus Artemisia: a comprehensive review. Pharm Biol 49: 101-09.

Brossat, J.Y., Ledeaut, J.Y., Ralamboranto, L., Rakotovao, L.H., Solar, S., Gueguen, A., Coulanges, P., 1981. Immunostimulating properties of an extract isolated from Aloe vahombe. 2. Protection in mice by fraction F1 against infections by Listeria monocytogenes, Yersinia pestis, Candida albicans and Plasmodium berghei. Archives de l'Institut Pasteur de Madagascar 48 (1) 1981, 11-34.

Butler, M. S., Robertson, A. A. B., & Cooper, M. A. (2004). Natural product and natural product derived drugs in clinical trials. Natural Product Reports, 21(6), 602-604.

C. Choi, G. Kang, and Y. Min; Reversal of P-glycoprotein-mediated multidrug resistance by protopanaxatriol ginsenosides from Korean red ginseng; Planta Medica; 2003; 69; 3, PP-235-240,.

Can, A., Akev, N., Ozsoy, N., Bolkent, S., Arda, B.P., Yanardag, R., Okyar, A., 2004. Effects of Aloe vera Leaf gel and pulp extracts on kidney in type-II diabetic rat model. Indian Journal of Experimental Biology. 42.1, 48-52

Cech, N. B., and Enke, C. G. (2001). Practical implications of some recent studies in electrospray ionization fundamentals. Mass Spectrometry Reviews, 20(6), 362-387

Chattopadhyay, I., K. Biswas, U. Bandyopadhyay and R.K. Banerjee, 2004. Turmeric and curcumin?: Biological actions and medicinal applications Current Sci., 87: 44-53.

Chen S, Wang Z, Huang Y, O’Barr SA, Wong RA, Yeung S, Chow MS. Ginseng and anticancer drug combination to improve cancer chemotherapy: a critical review. Evidence Based Complement Alternative Med. 2014; 168940. Doi: 10.1155/2014/168940. Epub 2014 Apr 30. PMID: 24876866; PMCID: PMC4021740.

Choi, Jang-Gi and Jin, Young-Hee and Lee, Heeeun and Oh, Tae Woo and Yim, Nam-Hui and Cho, Won-Kyung and Ma, JinYeul; Protective Effect of Panax notoginseng Root Water Extract against Influenza A Virus Infection by Enhancing Antiviral Interferon-Mediated Immune Responses and Natural Killer Cell Activity; Frontiers in Immunology;2017;8;PP-1542.

Chung SI, Kang MY, Lee SC. In Vitro and In Vivo Antioxidant Activity of Aged Ginseng (Panax ginseng); Preventive Nutritive Food Science; 2016;21(1):PP-24-30.

Cooks, R. G., Ouyang, Z., Takats, Z., and Wiseman, J. M. (2006). Ambient Mass Spectrometry. Science, 311(5767), 1566-1570.

Cragg, G. M., Kingston, D. G. I., & Newman, D. J. (2012). Anticancer Agents from Natural Products. CRC Press

De Paepe, D., Valkenborg, D., Noten, B., Servaes, K., Boyen, F., and De Spiegeleer, B. (2021). GC-MS data pre-processing for nontargeted analysis of plant volatiles: are dried samples suitable? Frontiers in Plant Science, 12, 699690.

de Rijke, E., Out, P., Niessen, W. M., Ariese, F., Gooijer, C., Brinkman, U. A. (2006). Analytical separation and detection methods for flavonoids. Journal of Chromatography A, 1112(1-2) 31–63.

Dettmer, K., Aronov, P. A., and Hammock, B. D. (2007). Mass spectrometry-based metabolomics. Mass Spectrometry Reviews, 26(1), 51-78.

Diamandis, E. P. (2004). Mass spectrometry as a diagnostic and a cancer biomarker discovery tool: Opportunities and potential limitations. Molecular & Cellular Proteomics, 3(4), 367-378.

Eiceman, G. A., and Karpas, Z. (2005). Ion Mobility Spectrometry, Second Edition. CRC Press.

Gillet, L. C., Navarro, P., Tate, S., Röst, H., Selevsek, N., Reiter, L., … & Aebersold, R. (2012). Targeted data extraction of the MS/MS spectra generated by data-independent acquisition: a new concept for consistent and accurate proteome analysis. Molecular & Cellular Proteomics, 11(6), O111-016717.

Heinrich, M., Edwards, S., Moerman, D. E., & Leonti, M. (2009). Ethnopharmacological field studies: A critical assessment of their conceptual basis and methods. Journal of Ethnopharmacology, 124(1), 1-17

Hoofnagle, A. N., and Wener, M. H. (2007). The fundamental flaws of immunoassays and potential solutions using tandem mass spectrometry. Journal of Immunological Methods, 347(1-2), 3-11.

Huang, W., Sun, W., & Wang, Y. (2012). Isolation and molecular characterisation of Flavonoid 3′-hydroxylase and flavonoid 3′, 5′-hydroxylase genes from a traditional Chinese medicinal plant, Epimedium sagittatum. Gene, 497(1). 125–130.

Hunter, J.A., Frumkin, A.,1991. Adverse reactions to vitamin E and aloe vera preparations after dermabrassion and chemical peel. Cutis 47.3, 193-196.

Im D-S. Pro-Resolving Effect of Ginsenosides as an Anti-Inflammatory Mechanism of Panax ginseng. Biomolecules. 2020; 10(3):444.

Jain, D. C., Bahuguna, Y. M., Bedi, Y. S., and Sharm, O. P. (2019). Medicinal and aromatic plants: A global heritage. In: Plant Diversity, Soil Fertility and Rehabilitation of Degraded Lands (pp. 241-265).

Johnson, M. Et al. (2022). “Multimodal Spectroscopic Analysis of Phytochemicals for Enhanced Structural Characterization.” Journal of Analytical Chemistry, 60(8), 1014-1029.

Kala, C. P. (2005). Indigenous uses, population density, and conservation of threatened medicinal plants in protected areas of the Indian Himalayas. Conservation Biology, 19(2), 368-378.

Kim HG, Yoo SR, Park HJ, et al. Antioxidant effects of Panax ginseng C.A. Meyer in healthy subjects: a randomized, placebo-controlled clinical trial.; Food Chemistry Toxicology; 2011;49(9); PP-2229-2235.

Kumar, N. And S.K. Sakhya, 2013 Ethnopharmacological Properties of Curcuma longa:A Review. Int. J. Pharm. Sci. Res., 4: 103-112.

Le TH, Lee GJ, Vu HK, Kwon SW, Nguyen NK, Park JH, et al. Ginseng saponins in different parts of Panax vietnamensis. Chem Pharm Bull. 2015;63(11):950 4.

 Le TH, Lee SY, Kim TR, Kim JY, Kwon SW, Nguyen NK, et al. Processed Vietnamese ginseng: Preliminary results in chemistry and biological activity. J Ginseng Res. 2014;38(2):154 9.

 Maizura, M., A. Aminah and W.M. Wan-Aida,2011. Total phenolic content and antioxidantactivity of kesum (Polygonum minus), ginger (Zingiber officinale) and turmeric (Curcuma longa) extract. Int. Food Res. J., 18: 529-534.

Makarov, A. (2000). Electrostatic axially harmonic orbital trapping: A high-performance technique of mass analysis. Analytical Chemistry, 72(6), 1156-1162.

Martin, A. J. P., & Synge, R. L. M. (1941). A new form of chromatogram employing two liquid phases. Biochemical Journal, 35(11-12), 1358-1368.

McDaniel, H.R., Carpenter, R.H., Kemp, M., 1990 Extended survival and prognostic criteria for acemannan (ACE-M) treated HIV-1 patients. Antiviral Research 1: 117-147

Miller, M.B., Koltai, P.J., 1995. Treatment of experimental frostbite with pentoxifylline and aloe vera cream. Archives of Otolaryngology - Head and Neck Surgery 121.6, 678-680.

Misra, B. B., and van der Heeft, E. (2010). Metabolic pathway analysis of phloem metabolites in Brassica napus using NMR spectroscopy and liquid chromatography. Journal of Experimental Botany, 61(6), 1797-1807.

Mitchell, D., et al. (2016). Quantitative phytochemical analysis of alkaloids in medicinal plants using liquid chromatography-mass spectrometry. Phytochemistry Research, 22(4), 501-515.

Montaner, J.S., Gill, J., Singer, J., Raboud, J., Arseneau, R., McLean, B.D., Schechter, M.T., Ruedy, J., 1996. Double- blind placebo- controlled pilot trial of acemannan in advanced human immunodeficiency virus disease.Journal of Acquired Immune Deficiency Syndromes and Human Retrovirolog 12.2, 153-157.

Mosmann, T. (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. Journal of Immunological Methods, 65(1-2), 55-63.

Newman, D. J., & Cragg, G. M. (2016). Natural Products as Sources of New Drugs from 1981 to 2014. Journal of Natural Products, 79(3), 629-661.

Nguyen MD, Nguyen TN, Kasai R, Ito A, Yamasaki K, Tanaka O. Saponins from Vietnamese ginseng, Panax vietnamensis ha et grushv. Collected in central Vietnam. I. Chem Pharm Bull. 1993;41(11):2010 4.

Pari, L., D. Tewas and J. Eckel, 2008. Role of curcumin in health and disease. Arch. Physiol. Biochem., 114: 127-149.

Park J and Cho JY; Anti-inflammatory effects of ginsenosides from Panax ginseng and their structural analogs; African Journal of Biotechnology; 2009; Vol. 8 (16); P 3682-3690.

Patel, A. Et al. (2020). “Infrared Spectroscopy for the Identification of Terpenoid Compounds in Medicinal Plants.” Journal of Natural Products, 50(4), 567-580.

Patel, R., Smith, T., & Johnson, A. (2020). Application of Phytochemical Analysis in Quality Control of Herbal Products. Journal of Herbal Medicine, 30(2), 87-103.

Pellati F, Benvenuti S, Melegari M, Lasseigne T. Variability in the composition of anti-oxidant compounds in Echinacea species by HPLC. Phytochem Anal 2005; 16(2): 77-85.

Peng Xue, Xiushi Yang, XiaoyanSunab and Guixing Ren; Antifungal activity and mechanism of heattransformed ginsenosides from notoginseng against Epidermophyton floccosum, Trichophyton rubrum, and Trichophyton mentagrophytes; Royal Society of Chemistry Advances; 2017; 7; P-10939.a

Raso GM, Pacilio M, Carlo G, Esposito E, Pinto L, Meli R. In-vivo and in-vitro anti-inflammatory effect of Echinacea purpurea and Hypericum perforatum. J Pharm Pharmacol 2002; 54(10): 1379-83

Reynolds, T., Dweek A.C., 1999. Aloe vera leaf gel. A review update. Journal of Ethnopharmacology 68.1-3, 3-37

Sarker, S. D., & Nahar, L. (2007). Natural medicine: The genus Tamarindus. Current Medicinal Chemistry, 14(2), 207-218.

Savikin, K., Zdunic, G., Menkovic, N., Živkovic, J., Cujic, N., Terzic, S., and Steševic, D. (2013). Ethnobotanical study on traditional use of medicinal plants in South-Western Serbia, Zlatibor district. Journal of Ethnopharmacology, 146(3), 803-810.

Shah, G., Shri, R., Panchal, V., Sharma, N., Singh, B., and Mann, A. S. (2015). Scientific basis for the therapeutic use of Cymbopogon citratus, stapf (Lemon grass). Journal of Advanced Pharmaceutical Technology & Research, 6(4), 177-183.

Shishodia, S., Sethi, G., & Aggarwal, B. B. (2007). Curcumin: getting back to the roots. Annals of the New York Academy of Sciences, 1056(1), 206-217.

Singh, R.P. and D.A. Jain, 2012. Evaluation ofAntimicrobial activity of curcuminoids isolated from Turmeric. Int. J. Pharm. Life Sci., 3: 1368-1376.

Sloley BD, Urichuk LJ, Tywin C, Coutts RT, Pang PK, Shan JJ. Comparison of chemical components

Smith, A. Et al. (2021). “Structural Characterization of Polyphenolic Compounds from Medicinal Plants by NMR Spectroscopy.” Journal of Natural Products Research, 55(6), 789-802.

Smith, J. Et al. (2019). “Application of UV-Vis Spectroscopy in the Analysis of Flavonoid Compounds in Medicinal Plants.” Journal of Phytochemistry, 45(2), 210-224.

Smith, J., & Jones, A. (2019). Mechanistic insights into the interaction of plant-derived compounds with human cells. Journal of Molecular Pharmacology, 42(3), 289-305.

Smith, J., Johnson, A., & Brown, C. (2021). Interdisciplinary Collaboration in Phytochemical Analysis. Journal of Medicinal Botany, 15(3), 123-136.

 Springer.Rastogi, S., Pandey, M. M., Rawat, A. K. S. (2015). An ethnomedicinal, phytochemical and pharmacological profile of Desmodium gangeticum (L.) DC. and Desmodium adscendens (Sw.) DC. Journal of Ethnopharmacology, 162, 98-123.

Thoppil, R. J., & Bishayee, A. (2011). Terpenoids as potential chemopreventive and therapeutic agents in liver cancer. World Journal of Hepatology, 3(9), 228–249.

Tripoli, E., Guardia, M. L., Giammanco, S., Majo, D. D., & Giammanco, M. (2007). Citrus flavonoids: Molecular structure, biological activity and nutritional properties: A review. Food Chemistry, 104(2), 466–479.

Tu, Y. (2011). The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine. Nature Medicine, 17(10), 1217-1220

Van Berkel, G. J., Kertesz, V., and King, R. C. (2018). Characterization of Biological Tissues by Desorption Electrospray Ionization Mass Spectrometry Imaging. Journal of Visualized Experiments, (133), e57333.

Venter, A., and Cooks, R. G. (2007). Ambient desorption ionization mass spectrometry. Trends in Analytical Chemistry, 26(7), 648-661.Cody, R. B., Laramee, J. A., and Durst, H. D. (2005).

Versatile new ion source for the analysis of materials in open air under ambient conditions. Analytical Chemistry, 77(8), 2297-2302.

Versatility of turmeric: A review the golden spice of life. Roshan Prasad Yadav Journal of Pharmacognosy and Phytochemistry. 2017; 6 (1): 41–46

Wilson, P., & Turner, S. (2019). Quantitative analysis of secondary metabolites in medicinal plants using advanced phytochemical techniques. Phytochemistry Letters, 28, 112-126.

Wu, X., Luo, A., Zhou, Y., Li, S., Ji, G., Liu, F., … & Guo, D. (2019). Echinacoside induces apoptosis in estrogen receptor-α-positive breast cancer cells through the ROS/p38 MAPK pathway. Phytotherapy Research, 33(5), 1399-1408.

Wüstenberg P, Henneicke-von Zepelin HH, Köhler G, Stammwitz U. Efficacy and mode of action of an immunomodulator herbal preparation containing Echinacea, wild indigo, and white cedar. Adv Ther 1999; 16(1): 51-70.

Yadav, D., S.K. Yadav, R.K. Khar, M. Mujeeb andM. Akhtar, 2013. Turmeric (Curcuma longa L.):A promising spice for phytochemical an pharmacological activities. Int. J. Green P., 7: 85-89.

Yates, J. R., Eng, J. K., McCormack, A. L., and Schieltz, D. (1995). Method to Correlate Tandem Mass Spectra of Modified Peptides to Amino Acid Sequences in the Protein Database. Analytical Chemistry, 67(8), 1426-1436.

Zhang, L., et al. (2017). Phytochemical analysis of traditional Chinese medicinal herbs. Journal of Ethnopharmacology, 153, 543-563.

Zhang, L., Tizard, I.R., 1996. Activation of a mouse macrophage cell line by acemannan: the major carbohydrate fraction from Aloe vera gel. Immunopharmacology 2, 119-128.

Zhang, X.F., 2008. Binding of the bioactive component Aloe dihydroisocoumarin with human serum albumin. Journal of Molecular Structure 1, 87-92

PDF
Full Text
Export Citation

View Dimensions


View Plumx



View Altmetric



0
Save
0
Citation
531
View
0
Share