MicroBio Pharmaceuticals and Pharmacology | Online ISSN 2209-2161
RESEARCH ARTICLE   (Open Access)

Prevalence and Immune Response with Interferons to BK Polyomavirus in Chronic Kidney Disease Patients

Ibrahim MS. Hussein 1*, Hajir A. Shareef 2

+ Author Affiliations

Microbial Bioactives 7(1) 1-7 https://doi.org/10.25163/microbbioacts.719848

Submitted: 15 April 2024  Revised: 21 June 2024  Published: 29 June 2024 

This study determined BKPyV prevalence in CKD patients, emphasizing the role of interferons in immune response and the need for vigilant monitoring.

Abstract


Background: BK polyomavirus (BKPyV) is recognized as a significant cause of renal impairment and graft failure in transplant recipients, with its reactivation posing severe complications, especially in immunocompromised individuals. Although BKPyV infection is well-documented in various populations, there is limited research on its prevalence and impact in Iraq, particularly among patients with chronic kidney disease (CKD). This study aimed to evaluate the prevalence of BKPyV in CKD patients and assess its relationship with interferon alpha and beta levels. Methods: The study included 130 CKD patients (76 males and 54 females) divided into hemodialysis (n=110) and conservative (non-dialysis) groups (n=20), along with a control group of 50 healthy blood donors. Blood samples were analyzed for BKPyV-specific antibodies (IgM and IgG) using ELISA. Interferon alpha and beta levels were also measured. Statistical analysis was conducted to assess the association between seropositivity, interferon levels, and demographic variables. Results: Among the non-dialysis CKD patients, 10% tested positive for anti-IgG, while all samples were negative for anti-IgM. In contrast, 19% of hemodialysis patients were anti-IgG positive, 14.5% were anti-IgM positive, and 8.2% were positive for both antibodies. Elevated levels of interferon alpha and beta were observed in seropositive patients compared to controls, with significant differences at P < 0.05. Male patients aged 20-29 and female patients aged 40-49 exhibited higher seropositivity rates. Conclusion: The study highlights a notable prevalence of BKPyV among CKD patients in Iraq, particularly those undergoing hemodialysis. Elevated interferon alpha and beta levels in seropositive patients suggest a significant role of these cytokines in the immune response against BKPyV infection. The findings also indicate demographic variations in seropositivity, emphasizing the need for targeted monitoring and management of BKPyV in CKD patients. Further research is needed to develop effective interventions for BKPyV-related complications in this high-risk population.

Keywords: BK Polyomavirus, Chronic Kidney Disease, Hemodialysis, Interferon Levels, Seropositivity

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