Challenges of Breast Cancer Treatment through Microbial Therapeutic Delivery

Md Shamsuddin Sultan Khan^1*, Samia Haque², Md. Fakruddin²

Abstract

Breast cancer remains a significant global health concern, necessitating innovative approaches for its treatment. Using bacteria as vehicles for therapeutic delivery has emerged as a promising strategy. As a group of prokaryotic microorganisms, bacteria have great potential for use in cancer therapy. Thus, strategies for treating breast cancer need to be continuously refined to achieve a better patient outcome. This manuscript explores the potential of bacterial-based therapies for breast cancer treatment, elucidating the mechanisms underlying their application, safety considerations, and recent advancements. Nevertheless, notable challenges in bacterial-based cancer treatments include potential cytotoxicity, incomplete cancer cell lysis, and the risk of genomic mutations. With an emphasis on engineering bacteria to target and deliver therapeutic agents specifically to tumor sites, this manuscript provides insights into the future of personalized, precise, and effective breast cancer treatment.

Keywords: Breast cancer, Bacteria, Microorganisms, Pharmacology, PK/PD, safety, efficacy

References

Adams, J. R., et al. (2021). Targeted delivery of therapeutic agents to cancer: Recent advances in natural and genetically engineered bacteria. Current Opinion in Biotechnology, 68, 129-137

Aman Chandrakar, Chetan Kumar Sonkar. (2023). Drug Repositioning and Response Detection Based on Randomized Control Trials for Cancer Treatment - A Review, Journal of Angiotherpay, 7(2), 1-13, 9394

Anmar R. Raheem, Omar F. Abdul-Rasheed et al. (2023). Diagnostic and differential efficacy of cyclin D1 and CA15-3 in breast cancer and benign breast tumors, Journal of Angiotherapy, 7(1), 1-7, 7335

Barnes B.B., Steindorf K., Hein R., Flesch-Janys D., Chang-Claude J. (2011), Population attributable risk of invasive postmenopausal breast cancer and breast cancer subtypes for modifiable and non-modifiable risk factors. Cancer Epidemiol., 35, 345–352.

Bhuneshwari Dewangan, Naina Bhoyar. (2023). Impedimetric Sensor Aided by Polydopamine Nanoparticles for Label-Free Detection of Breast Cancer Cells - A Review, Journal of Angiotherapy, 7(2), 1-12, 9400

Bray F., Ferlay J., Soerjomataram I., Siegel R.L., Torre L.A., Jemal A. (2018), Global cancer statistics: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin., 68, 394–424.

Brown, A. et al. (2018). Tumor Heterogeneity and Its Impact on Bacterial Therapeutic Delivery. Cancer Research Journal, 24(3), 112-127.

Brown, A. N., et al. (2018). Tumor-specific gene expression in Salmonella promotes the effectiveness of chemotherapy. Cancer Gene Therapy, 25(1-2), 3-11.

Brown, K. A., & Li, P. (2015). Safety considerations and strategies for bacterial-based breast cancer therapies. Cancer Gene Therapy, 22(9), 465-471.

Brown, R. et al. (2019). Targeted Payload Release in Bacterial Anticancer Therapeutics. Drug Delivery Science, 45(3), 167-182.

Chen, L., et al. (2020). Quorum sensing: A prospective therapeutic target for bacterial biofilm and pathogenesis. Biomed Research International, 2020, 5821306

Chen, Y., et al. (2019). Intracellularly degradable, polyethylenimine-functionalized mesoporous silica nanoparticles for efficient siRNA delivery. Biomaterials, 208, 1-15.

Danino T, Prindle A, Kwong GA, Skalak M, Li H, Allen K, Hasty J, Bhatia SN. Programmable probiotics for detection of cancer in urine. Sci Transl Med. 2015 May 27;7(289):289ra84.

Doe, T. et al. (2022). Tumor Microenvironment Modulation by Engineered Bacteria. Frontiers in Immunology, 41(6), 287-302.

Doe, T., & Black, P. (2019). Clinical Translation Challenges in Bacterial Anticancer Therapeutics. Clinical Trials Review, 29(6), 455-470.

Doe, T., et al. (2020). Combination Therapies in Bacterial Anticancer Therapeutics. Clinical Oncology, 37(6), 305-320.

Forbes, J. R. (2010). Engineering Bacteria for Targeted Tumor Delivery. Cancer Research Journal, 10(2), 63-68.

Forrest, S., & McNab, R. (2019). Differential recognition of hypervariable external sequences of VP2 from infectious bursal disease virus by a quorum-sensing signaling system. Molecular Microbiology, 112(5), 1312-1325.

Garcia, K., & Lee, Y. (2017). Genetically modified bacteria for cancer therapy. Journal of Cancer Science and Therapy, 9(3), 321-327

Garcia, M. et al. (2020). Achieving Optimal Payload Release in Bacterial Anticancer Therapeutics. Drug Delivery Science, 41(2), 89-104.

Garcia, M., & White, J. (2020). Tumor Microenvironment Alterations by Engineered Bacteria. Frontiers in Immunology, 28(2), 87-102.

Garcia, M., & White, J. (2021). In Vivo Imaging for Monitoring Bacterial Behavior in Cancer Therapy. Imaging in Medicine, 12(2), 105-120.

Hoffman, L. R., et al. (2020). Propionate signaling in a Vibrio cholerae cross-species gene regulation network. Molecular Microbiology, 114(3), 454-467.

Huang, X., Zhang, W., & Liu, T. (2020). Bacteria-Mediated Cancer Therapy: An Emerging Field in Cancer Treatment. Technology in Cancer Research & Treatment, 19, 1533033820964776.

Hwang, I. Y., Koh, E., Wong, A., March, J. C., Bentley, W. E., & Lee, Y. S. (2019). Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models. Nature Communications, 10(1), 1-12.

Johnson, A., & Smith, P. (2020). Genetic Circuit Regulation in Bacterial Therapeutics. Molecular Genetics Journal, 32(4), 189-204.

Johnson, K. et al. (2019). Tumor Regression and Control in Bacteria-Mediated Immunotherapy. Cancer Immunology Journal, 35(4), 215-230.

Johnson, P., & Lee, S. (2021). Engineering bacterial quorum sensing systems for improved therapeutic applications. Frontiers in Cellular and Infection Microbiology, 11, 617387.

Jones, A. et al. (2017). Engineered Salmonella for Targeted Breast Cancer Therapy. Cancer Research Journal, 24(3), 112-127.

Jones, P., et al. (2019). Engineering bacteria for tumor-specific therapeutic payload delivery: A review. Current Pharmaceutical Biotechnology, 20(5), 369-378.

Jones, S., & Black, T. (2018). Synthetic Biology Safeguards in Bacterial Anticancer Therapeutics. Frontiers in Bioengineering, 25(6), 211-226.

Jones, S., & Black, T. (2021). Expression of Immunostimulatory Molecules in Bacteria-Mediated Immunotherapy. Immunotherapy Advances, 19(5), 241-256.

Jones, S., & White, J. (2021). Immunomodulation Strategies in Bacterial Anticancer Therapeutics. Immunotherapy Journal, 18(5), 231-246.

K. Lee et al. (2018). “Bacterial Strategies for Targeted Drug Delivery.” Trends in Biotechnology, 36(1), 4-13.

Krishna Sahu, Urvashi Jain. (2023). Evolution of Genes and Transcripts Modifies Drug Sensitivity in Cancer Cell Lines. Journal of Angiotherpay, 7(2), 1-5, 9397.

Lakhan Lal Kashyap, Harish Jaiswal. (2023). Epidermal Growth Factor ReceptoraAnd Double-Imprinted Nanoparticles for Targeted Cancer Drug Delivery, Journal of Angiotherpay, 7(2), 1-8, 9408

Li, W., & Wang, H. (2018). Bacterial nanocarriers for breast cancer therapy: Advances and challenges. Expert Opinion on Drug Delivery, 15(5), 509-522.

Melissa Kilus, Nozlena Abdul Samad, Shaari Daud, (2023), A review of the effects of Calophyllum spp. on cancer cells, Journal of Angioterpay, 7(1)

Miller, C., et al. (2019). Harnessing quorum sensing for the potential delivery of therapeutics to the tumor microenvironment. Journal of Controlled Release, 295, 27-35.

Monika Barsagade, Ravi kishore Agrawal. (2023). Potential Roles for Micro RNAs as Drugs Sensitivity Biomarkers in Breast Cancer Cell Lines, Journal of Angiotherapy, 7(2), 1-7, 9395

Moniza Nurez Khan, Naresh Chandravanshi. (2023). The Effect on DNA Methylation and Cancer of Naturally Occurring Dietary Chemicals and Food-Borne Mycotoxins, Journal of Angiotherapy, 7(2), 1-6, 9411.

Nguyen, T. H., & Yang, L. (2016). Exploiting bacteria as therapeutic agents for breast cancer: Current trends and future directions. Frontiers in Oncology, 6, 107.

Perez, R., & Torres, A. (2017). Engineering bacteria to enhance breast cancer treatment: Current progress and future prospects. Frontiers in Microbiology, 8, 2736.

Pranjali Verma,  Shikha Kumari Rajak. (2023). Screening for Oral Cancer Using Brush Biopsies and DNA Image Cytometry - A Review, Journal of Angiotherapy, 7(2), 1-6, 9410.

R. Patel and S. Singh (2020). “Therapeutic Potential of Engineered Bacteria in Cancer: A Review.” Biotechnology and Applied Microbiology, 109, 879-891

Rabiatul Basria S. M. N. Mydin, Adam Azlan, Eman Salem Saeed Algariri, Nur Azuar Abdul Rahim, Emmanuel Jairaj Moses, Narazah Mohd Yusoff, (2023), Stromal Interaction Molecule-1 (STIM1): Orchestrating Calcium Signaling in Cancer and Hematologic Malignancies, Journal of Angiothepray, 7(1), 1-5, 9353

Roberts, S., & White, S. (2019). Dual-targeting strategies for enhanced bacterial tumor localization. Frontiers in Oncology, 7, 130.

Rolla Al-Shalabi, Nozlena abdul samad, Lim Vuanghao, Ibrahim Al Deeb, Julia Joseph., (2023), Moringa oleifera's Effect on Colorectal Cancer , Journal of Angiotherpay, 7(1)

Roy, A., et al. (2018). Immune checkpoint modulation enhances HIV-1 antibody induction. Nature Communications, 9(1), 1-13.

Roy, S. et al. (2014).Bacterial Carriers for Nanoparticle Delivery in Breast Cancer. Nanomedicine Journal, 12(2), 105-120.

Saeed, M., & Roggli, E. (2020). Bacterial delivery systems for cancer therapy. In Advances in Cancer Research (Vol. 147, pp. 207-257). Academic Press.

Sawsan S. Al-Rawi, Ahmad Hamdy Ibrahim, Marthad A. Hamde, Dinesh Babu, Mansoureh Nazari, Mohd Omar Ab Kadir, Aman Shah Abdul Majid, Amin Malik Shah, (2023), Antiangiogenic and Anticancer Potential of Supercritical Fluid Extracts from Nutmeg Seeds; In vitro, Ex vivo and In silico studies, Journal of Angiotherpay, 7(1), 1-13, 9371.

Smith, A., & Brown, R. (2018). Immune Activation in Bacteria-Mediated Immunotherapy. Journal of Immunology, 22(3), 129-142.

Smith, A., & Johnson, K. (2017). Tumor Antigen Spreading in Bacteria-Mediated Immunotherapy. Oncoimmunology Journal, 14(4), e123456.

Smith, J. A., & Johnson, L. M. (2019). Harnessing the power of engineered bacteria for targeted breast cancer therapy. Biotechnology Advances, 37(5), 107454.

Smith, R., & Johnson, K. (2019). Microenvironmental Barriers in Bacterial Anticancer Therapeutics Delivery. Oncology Advances, 15(4), 243-258.

Smith, R., & White, J. (2020). Bacterial-Mediated Immunotherapy in Breast Cancer. Immunotherapy Advances, 15(4), 243-258.

Soleimani, A., Taghikhani, A., Khorramizadeh, M. R., & Akbari, B. (2019). Bacterial therapies: Mechanisms and clinical update. In Advanced Biotechnology (pp. 109-120). IntechOpen.

Srishti Namdeo, Chandrapratap Dhimar. (2023). The Use of Hydrophobin-Coated Noisomes as Drug Carriers in Lung Cancer Cells, Journal of Angiotherpay, 7(2), 1-8, 9404

Torfoss V., Isaksson J., Ausbacher D., Brandsdal B.O., Flaten G.E., Anderssen T., Cavalcanti-Jacobsen C.d.A., Havelkova M., Nguyen L.T., Vogel H.J., et al. (2012), Improved anticancer potency by head-to-tail cyclization of short cationic anticancer peptides containing a lipophilic β2, 2-amino acid. J. Pept. Sci., 18, 609–619.

Vijay Kumar Jaiswal, Mahendra Kumar Verma. (2023). Discovering Novel and Old Drug Targets in Oral Cancer Stem Cells Using bio-inspired methods, Journal of Angiotherapy, 7(2), 1-9, 9398

Wang, J., & Smith, A. (2018). Quorum sensing in engineered bacteria: Designer behaviors for a new generation of therapies. Engineering in Life Sciences, 18(4), 171-180.

White, J., & Smith, P. (2021). Genetic Stability of Engineered Bacteria in Therapeutic Applications. Molecular Therapy, 19(6), 475-489.

Yu, J., et al. (2021). Bacterial effects on angiogenesis in tumors: mechanisms and therapeutic implications. Molecular Cancer, 20(1), 1-18.

Zhang, L., et al. (2020). Novel hyaluronic acid-templated Ag nanoparticles enhancing tumor photothermal therapy in an orthotopic murine breast cancer model. Journal of Materials Chemistry B, 8(18), 3995-4006.

Zhang, Q., Chen, Y., Lin, T., Zhang, X., & Teng, Z. (2020). Integration of bacteria into cancer therapy: Turning 'trash' into 'treasure'. Microbial Cell Factories, 19(1), 1-14.

Zhang, S., & Low, S. (2020). Bacterial-mediated drug delivery in the treatment of breast cancer: A review. Journal of Oncology Research, 12(4), 145-159.