Biosensors and Nanotheranostics
Bionanotechnology, Drug Delivery, Therapeutics | online ISSN 3064-7789
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RESEARCH ARTICLE   (Open Access)
Contents Vol 2 (1)

Inorganic Drug Release from Mesoporous Silica Nanoparticles for Cancer Treatment

Carla Caramella 1*

+ Author Affiliations

Biosensors and Nanotheranostics 2 (1) 1-6 https://doi.org/10.25163/biosensors.219842

Submitted: 17 July 2023 Revised: 05 September 2023  Published: 09 September 2023 

Abstract

Mesoporous Silica Nanoparticles (MSNs) were synthesized via a modified sol-gel Stöber process. The effect of various parameters - sodium hydroxide concentration, co-solvent, stirring rate, aging time and stirring time – on the size, morphology and monodispersity of the particles was investigated. The reproducible MSNs developed were spherical, 80.24 ± 11.80 nm in size, monodispersed, had a large surface area (690.34 m2/g) and pore volume (0.89 cm3/g). These properties deemed our MSNs ideal carriers for the delivery of therapeutic ions to cancer cells. Zinc and iron were incorporated, together and separately, into the silica network via a post-synthetic incorporation technique followed by calcination. Zinc ions have a preferential toxicity towards cancer cells, which leads to a pH-triggered release. The addition of ions to the particles did not affect their size or morphology. The washing step was proven crucial to preserve the monodispersity of the particles. Results suggest that zinc is probably acting as a network modifier (decreases network connectivity) and iron as a network former (increases network connectivity). The behaviour of iron(III) chloride and iron(III) nitrate as precursors was compared. Iron(III) chloride produced predominantly large localized hematite crystals (25.75 ± 3.19 nm). Iron(III) nitrate gave rise to mainly small homogeneously-spread magnetite crystals (2.70 ± 0.50 nm), which is desired. The incorporation of iron into to the MSN-Zn network slowed down the release of zinc, making the release less toxic. Iron tightens the silica network and it does not get released.

Keywords: Mesoporous Silica Nanoparticles (MSNs), Drug Delivery Systems, Cancer Therapy, Zinc and Iron Ions, Controlled Release Mechanism

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