MicroBio Pharmaceuticals and Pharmacology | Online ISSN 2209-2161
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Synergistic Efficacy and Mechanism of Probiotics and Prebiotics in Enhancing Health Impact

Sultan Ayesh Mohammed Saghir 1*, Fouad Saleh Al Suede 1

+ Author Affiliations

Microbial Bioactives 7(1) 1-11 https://doi.org/10.25163/microbbioacts.719300

Submitted: 09 November 2023  Revised: 03 January 2024  Published: 10 January 2024 

Abstract

The potential benefits of probiotics and prebiotics for enhancing human health are increasingly recognized. This review aims to investigate their effectiveness and underlying mechanisms in improving the gut microbiome and overall well-being. Probiotics are live bacteria that offer health advantages when consumed in adequate amounts, typically found in fermented foods or supplements. They help restore and maintain a healthy gut microbiome by regulating the immune system, promoting microbial diversity, and inhibiting harmful microorganisms. Clinical studies have shown their efficacy in treating gastrointestinal conditions like irritable bowel syndrome, as well as non-gastrointestinal issues such as allergies and immune function. Prebiotics, on the other hand, are indigestible substances, primarily dietary fibers, that serve as food for beneficial gut bacteria. By providing essential nutrition, prebiotics create an environment conducive to the growth and activity of these microorganisms, benefiting overall gut health. They have shown promise in managing conditions like type 2 diabetes and obesity by altering the gut flora composition. Understanding how probiotics and prebiotics work together, known as synbiotics, can enhance their efficacy in improving gut health and well-being. Ongoing research into their mechanisms of action enables personalized healthcare approaches. However, individual factors like genetics and baseline gut microbiota composition may influence their effectiveness. By modulating the gut flora, probiotics and prebiotics offer exciting opportunities for health improvement. Their actions include microbiological balance, immune regulation, and metabolic effects. This comprehensive understanding provides a solid foundation for leveraging their therapeutic potential and advancing contemporary healthcare.

Keywords: Probiotics, Prebiotics, Gut microbiome, Efficacy, Mechanisms of action, Health

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