Synthesis and Characterization Gold Nanoparticles using polymeric micelles to Induce Block Copolymer Composition
Ikram Ullah Khan 1*
Biosensors and Nanotheranostics 1(1) 1-8 https://doi.org/10.25163/biosensors.119837
Submitted: 01 November 2022 Revised: 05 December 2022 Published: 07 December 2022
Abstract
Background: Gold nanoparticles (AuNPs) have shown significant potential in biomedicine, particularly for applications in photothermal therapy and drug delivery. Conventional AuNP synthesis methods are often complex and involve multiple steps, driving interest in simpler, cost-effective alternatives. This study explores a novel approach using amine-containing polymeric micelles for the synthesis of AuNPs, aiming to streamline the process and enable precise control over nanoparticle properties. Methods: Seven block copolymers were synthesized via group transfer polymerization (GTP), including poly(ethylene glycol) methyl ether methacrylate (PEGMA), 2-(diethylamino)ethyl methacrylate (DEAEMA), and propargyl methacrylate (PMA). These copolymers varied in composition and architecture to investigate their self-assembly behavior and potential for AuNP formation. The structural properties were characterized using gel permeation chromatography (GPC) and proton nuclear magnetic resonance (¹H NMR) spectroscopy. Solution properties, such as pKa values, cloud points, and hydrodynamic diameters, were assessed using potentiometric titration, visual tests, and dynamic light scattering (DLS). Results: All synthesized polymers successfully formed micelles, with polymer 2 (PEGMA12-b-DEAEMA26-b-PEGMA12-b-PMA2) showing optimal properties for AuNP formation at pH 7 and 8. Ultraviolet-visible spectroscopy (UV-vis) and DLS analyses confirmed AuNP synthesis, with particle size varying depending on the pH. Conclusion: The study demonstrates the feasibility of using amine-containing polymeric micelles to synthesize AuNPs in a cost-effective manner. The results highlight the potential for optimizing polymer composition and architecture to tailor micellar behavior and AuNP properties, providing a promising approach for future biomedical applications.
Keywords: Gold nanoparticles (AuNPs), Polymeric micelles, Block copolymers, Group transfer polymerization (GTP), Biomedical applications
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