Natural Environmental Sources of Resveratrol and Its Therapeutic Role in Cancer Prevention
Md Rahedul Islam1, Tamanna Yesmin1, Amatun Noor Prapty2, Md Abdur Rahman Biswash3, Md Sohel Rana4, Md Haroon Or Rashid5*
Australian Herbal Insight 7(1) 1-11 https://doi.org/10.25163/ahi.719931
Submitted: 07 April 2024 Revised: 17 July 2024 Published: 21 July 2024
Abstract
Resveratrol, a polyphenolic compound found in plants like grapes and berries, is gaining recognition for its potent anti-cancer, anti-inflammatory, and antioxidant properties. This review offers a comprehensive examination of resveratrol’s role in cancer prevention and treatment, focusing on its ability to modulate key signaling pathways such as NF-κB, PI3K/Akt, and apoptotic regulators. Resveratrol also reduces oxidative stress by scavenging reactive oxygen species (ROS), contributing to its therapeutic potential. Despite its promise, challenges related to resveratrol’s absorption, distribution, metabolism, and excretion (ADME) limit its clinical application. Recent advancements in drug delivery systems, including liposomes and nanoparticles, have shown potential to improve its bioavailability and therapeutic efficacy. This review also addresses the compound’s safety, toxicity profiles, and interactions with other cancer therapies. Preclinical studies reveal resveratrol’s preventive efficacy, with findings suggesting reductions in the risk of breast and colon cancers by 60–80% through inhibition of precancerous lesions. Additionally, emerging research highlights resveratrol’s synergistic effects when used alongside chemotherapy and radiotherapy, enhancing treatment outcomes. Future research should prioritize large-scale clinical trials to optimize dosage, evaluate the long-term safety, and explore innovative delivery methods to realize resveratrol’s therapeutic potential in cancer carefully. Resveratrol stands as a promising agent in cancer prevention and treatment, warranting further investigation into its clinical applications.
Keywords: Resveratrol, cancer prevention, apoptosis, bioavailability, signaling pathways.
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