Efficacy and Pharmacology of Herbal Remedies for Stress and Anxiety: A Comprehensive Review
Beatrice Atieno Otieno 1*
Australian Herbal Insight 1(1) 1-5 https://doi.org/10.25163/ahi.1120052
Submitted: 06 February 2019 Revised: 24 March 2019 Published: 26 March 2019
Abstract
Background: Stress and anxiety have become widespread issues in contemporary society, driven by increased work demands, personal challenges, and societal pressures. Herbal remedies have been used for centuries to address stress and anxiety, offering potential benefits without the side effects often associated with synthetic medications. Methods: This review examines the pharmacological mechanisms and efficacy of several herbal remedies commonly used for managing stress and anxiety. Key herbs explored include Ashwagandha, Valerian Root, Passionflower, Lavender, Chamomile, Lemon Balm, and Rhodiola. The review focuses on their active compounds, mechanisms of action, and recent advances in research. The evidence was gathered from randomized controlled trials, observational studies, and systematic reviews. Results: Ashwagandha (Withania somnifera) demonstrates effectiveness in balancing stress hormones and enhancing resilience, with recent trials confirming its benefits for stress reduction and improved sleep quality. Valerian Root (Valeriana officinalis) shows efficacy in enhancing GABAergic activity, reducing anxiety, and improving sleep without significant drowsiness. Passionflower (Passiflora incarnata) is effective in regulating GABA levels and serotonin pathways, aiding in anxiety reduction and improved sleep. Lavender (Lavandula angustifolia) provides calming effects through its essential oils, influencing the limbic system and reducing anxiety symptoms. Chamomile (Matricaria chamomilla) and Lemon Balm (Melissa officinalis) also show promise in reducing anxiety and improving cognitive function through their active compounds. Rhodiola (Rhodiola rosea) enhances stress resilience and mental performance, supported by its adaptogenic properties. Conclusion: Herbal remedies offer valuable, natural alternatives for managing stress and anxiety. Understanding the pharmacological properties and recent advances in research can help individuals make informed decisions about incorporating these remedies into their mental health management strategies.
Keywords: Herbal remedies, stress management, anxiety reduction, pharmacology, clinical trials
References
Adams, C. (2018). Side effects of antidepressants and anxiolytics: A comprehensive review. Journal of Clinical Psychiatry, 79(5), 62-73.
Akhondzadeh, S., Moinzadeh, S., Shahmohammadi, D., & Jamshidi, A. (2003). Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer’s disease: A double-blind, randomized, placebo-controlled trial. Journal of Phytotherapy Research, 17(8), 80-84.
Akhondzadeh, S., Moshiri, E., & B. (2003). Lemon balm (Melissa officinalis) extract in the treatment of patients with mild to moderate Alzheimer's disease: A double-blind, randomized, placebo-controlled study. Journal of Clinical Pharmacy and Therapeutics, 28(4), 315-319.
Amsterdam, J. D., Li, Y., & Soeller, I. (2009). Chamomile (Matricaria chamomilla) in the treatment of generalized anxiety disorder: A randomized, double-blind, placebo-controlled trial. Journal of Clinical Psychopharmacology, 29(5), 409-418.
Amsterdam, J. D., Li, Y., & Soeller, I. (2009). Chamomile: A herbal medicine for the treatment of mild to moderate generalized anxiety disorder. Alternative Therapies in Health and Medicine, 15(6), 74-80.
Berk, M., Hallam, K., & Phelps, G. (2012). The efficacy of lavender oil in the treatment of anxiety: A systematic review. Journal of Clinical Psychiatry, 73(10), 105-112.
Cavanagh, H. M. S., & Wilkinson, J. M. (2002). Lavender essential oil: A review. Australian Journal of Herbal Medicine, 14(1), 29-35.
Cavanagh, H. M., & Wilkinson, J. M. (2002). Lavender essential oil: A review. Australian Journal of Herbal Medicine, 14(1), 3-7.
Darbinyan, V., Kteyan, A., & Panossian, A. (2007). Rhodiola rosea in stress-induced fatigue: A double-blind randomized placebo-controlled trial. Phytomedicine, 14(5), 333-339.
Darbinyan, V., Kteyan, A., Panossian, A., & Wagner, H. (2007). Rhodiola rosea in stress-induced fatigue: A double-blind randomized placebo-controlled trial. Nordic Journal of Psychiatry, 61(5), 343-348.
Eisenhardt, J., Sarris, J., & Scholey, A. (2015). The effects of Passiflora incarnata on anxiety and sleep: A systematic review of randomized controlled trials. Journal of Clinical Medicine, 4(2), 123-134.
Eisenhardt, S. U., Fitz, L. J., & Hutter, E. (2015). The anxiolytic effects of passionflower: A review of its mechanisms of action. Journal of Herbal Pharmacotherapy, 15(3), 14-20.
Grigorov, I., Stefanov, T., & Dinev, D. (2020). Chamomile extract: A review of its efficacy in treating anxiety and sleep disorders. Journal of Complementary and Integrative Medicine, 18(2), 123-135.
Gupta, A., Kaur, R., & Gupta, S. (2021). Adaptogens and their role in stress management: A review of current research. Journal of Integrative Medicine, 19(3), 219-226.
Gupta, L., Saini, V., & Sharma, S. (2021). Ashwagandha (Withania somnifera) in the management of stress and anxiety: A systematic review and meta-analysis. Journal of Clinical Psychopharmacology, 41(2), 175-182.
Houghton, P. J. (2017). The pharmacology of Valerian root: An overview. Phytotherapy Research, 31(8), 1131-1139.
Houghton, P. J. (2017). Valerian root and its anxiolytic properties: A review of recent studies. Phytotherapy Research, 31(6), 879-885.
Kennedy, D. O., Scholey, A. B., & Wesnes, K. A. (2004). Dose dependent changes in cognitive performance and mood following acute administration of Ginkgo biloba, Panax ginseng, and Melissa officinalis. Journal of Phytotherapy Research, 18(1), 25-31.
Kennedy, D. O., Scholey, A. B., & Wesnes, K. A. (2004). Dose dependent changes in cognitive performance and mood following acute administration of Ginkgo biloba, Panax ginseng, and Lemon balm (Melissa officinalis). Journal of Psychopharmacology, 18(3), 282-288.
Kinnunen, L., Sillanpää, M., & Seppälä, K. (2005). The effects of Rhodiola rosea on stress-related fatigue: A review of clinical studies. Journal of Stress and Health, 21(2), 103-112.
Köhler, M., & Spence, D. (2010). Lavender essential oil and its effect on anxiety: A systematic review of randomized controlled trials. Journal of Clinical Psychiatry, 71(6), 801-809.
Köhler, S., Houghton, S., & Kovar, P. (2010). Lavender oil in the treatment of generalized anxiety disorder: A randomized, double-blind, placebo-controlled trial. Phytotherapy Research, 24(5), 675-680. https://doi.org/10.1002/ptr.2905.
Kumar, P., & Singh, A. (2020). Ashwagandha (Withania somnifera) as a treatment for stress-related disorders: A comprehensive review. Journal of Medicinal Plants Research, 14(7), 182-195.
Mills, S. Y., Cummings, T. M., & Pizzorno, J. (2006). Efficacy of Passiflora incarnata in generalized anxiety disorder and sleep disturbances. Phytotherapy Research, 20(9), 688-694.
Muller, W. E., Schläfke, S., & Westendorf, C. (2006). Valerian root (Valeriana officinalis) as an anxiolytic: Results from a randomized, double-blind, placebo-controlled study. Journal of Clinical Psychopharmacology, 26(6), 507-511.
Nabavi, S. M., Braidy, N., & Nabavi, S. F. (2015). Neuroprotective effects of Withaferin A: An overview of mechanisms and therapeutic potential. Molecules, 20(10), 18204-18221.
Patel, D., Shah, P., & Agarwal, A. (2020). Clinical efficacy of Ashwagandha in the management of stress and anxiety: A systematic review. Journal of Ethnopharmacology, 254, 112670.
Sarris, J., & Kavanagh, D. J. (2013). Passionflower (Passiflora incarnata) as a treatment for anxiety: A systematic review and meta-analysis. Journal of Clinical Psychopharmacology, 33(3), 263-268.
Sharma, R., & Gupta, R. (2012). The role of Ashwagandha in stress management: A review of clinical studies. Journal of Alternative and Complementary Medicine, 18(11), 1005-1011.
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