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Paradise Journal is an international, peer-reviewed, open-access platform dedicated to publishing high-quality research in the fields of life sciences, engineering, business, and natural s

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Editor-in-Chief: Md. Moyen Uddin PK, Ph.D.

Paradise

Volume 1 Number 1 2025

Table of Contents


Research Article

Computational Biology

Published online 14 April 2025

Encoded Resistance: Structural Disruption and Signaling Crosstalk Undermine Sorafenib Binding in Mutant VEGFR2-Driven HCC

Tufael1*, Most Farhana Akter2, Md. Robiul Islam2, Md Abu Bakar Siddique3, Nashitha Hassan1, Abdullah Al Numan4, Asika Ayrin Naher4, Md Mahedi Hasan Shabuj4, Amena Khatun Manica5, Bulbul Shaikat6, Tahsin Bin Rabbani6

pp. 1-9

VEGFR2 mutations weaken sorafenib binding and start backup pathways, explaining resistance and supporting combined, multi-target treatments for liver cancer.

Abstract | Full Text |PDF (645 KB) | Open Access Article


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