Paradise

Paradise | Life Science Engineering Business Natural Science | Online ISSN 3070-1643
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Paradise

Paradise Journal is an international, peer-reviewed, open-access platform dedicated to publishing high-quality research in the fields of life sciences, engineering, business, and natural s

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Editor-in-Chief: Md. Moyen Uddin PK, Ph.D.

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Paradise

Volume 1 Number 1 2025

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Research Article

Computational Biology

Research Article | Computational Biology
Published online 14 April 2025

Encoded Resistance: Structural Disruption and Signaling Crosstalk Undermine Sorafenib Binding in Mutant VEGFR2-Driven HCC

Tufael1*, Most Farhana Akter2, Md. Robiul Islam2, Md Abu Bakar Siddique3, Nashitha Hassan1, Abdullah Al Numan4, Asika Ayrin Naher4, Md Mahedi Hasan Shabuj4, Amena Khatun Manica5, Bulbul Shaikat6, Tahsin Bin Rabbani6

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Views: 525 | Downloads: 15

VEGFR2 mutations weaken sorafenib binding and start backup pathways, explaining resistance and supporting combined, multi-target treatments for liver cancer.

Abstract | Full Text |PDF (645 KB) | Open Access Article


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