Assessment of Lipid Profile in Hepatocellular Carcinoma Patients: A Prospective Study In Bangladesh
Md Tahsin Salam1, Moushumi Afroza Mou2, Kaniz Fatima Bari3, Nikhil Chandra Roy4, Abdullah-Al-Mamun5, Md. Sefaut Ullah6, Mohammad Anowar Hussen7, Md Sohel Rana8, Md Babul Hossain9
Journal of Primeasia 5(1) 1-8 https://doi.org/10.25163/primeasia.519787
Submitted: 21 January 2024 Revised: 20 March 2024 Published: 25 March 2024
Abstract
Background: Hepatocellular carcinoma (HCC) is a significant cause of cancer-related mortality globally, with a high incidence in Bangladesh. Disruptions in lipid metabolism are a hallmark of liver diseases, including HCC. Understanding the lipid profile in HCC patients can provide insights into the disease's pathophysiology and aid in developing diagnostic and therapeutic strategies. Objective: This study aims to assess the lipid profile in HCC patients in Bangladesh to identify potential diagnostic markers and understand the metabolic alterations associated with the disease. Method: A prospective study was conducted on 356 HCC patients admitted to IBN Sina Specialized Hospital, Dhaka, between June 2022 and December 2023. Blood samples were collected to measure total cholesterol levels, triglycerides, high-density lipoprotein (HDL), and low-density lipoprotein (LDL). The lipid profiles of these patients were compared with a control group of healthy individuals. Results: HCC patients exhibited significant alterations in their lipid profiles compared to the control group. Total cholesterol increased by 18.3% (220 mg/dL vs. 186 mg/dL), triglycerides by 25% (190 mg/dL vs. 152 mg/dL), LDL cholesterol by 29.6% (140 mg/dL vs. 108 mg/dL), and HDL cholesterol decreased by 22.4% (38 mg/dL vs. 49 mg/dL) (p<0.001). Advanced tumor stages showed an additional 10% reduction in HDL and a 15% increase in LDL. Impaired liver function led to a further 12% rise in total cholesterol and 20% in triglycerides. These lipid changes were significantly associated with HCC progression and poorer prognosis. Conclusions: The study demonstrates significant dyslipidemia in HCC patients, suggesting that lipid profile alterations could serve as potential biomarkers for early detection and prognosis of HCC. Further research into lipid metabolism pathways in HCC could lead to novel therapeutic targets.
Keywords: Hepatocellular Carcinoma, Lipid Profile, Dyslipidemia, Biomarker.
References
Akkiz, H., Carr, B. I., Guerra, V., Donghia, R., Yalçin, K., Karaogullarindan, U., ... & Delik, A. (2021). Plasma lipids, tumor parameters and survival in HCC patients with HBV and HCV. Journal of translational science, 7(3).
Almohaid, S., & Akhtar, S. (2024). Diet, lifestyle factors, comorbidities, and hepatocellular carcinoma risk in a middle eastern country: a case-control study. BMC cancer, 24(1), 694.
Ashrafizadeh, M., Javanmardi, S., Moradi-Ozarlou, M., Mohammadinejad, R., Farkhondeh, T., Samarghandian, S., & Garg, M. (2020). Natural products and phytochemical nanoformulations targeting mitochondria in oncotherapy: an updated review on resveratrol. Bioscience reports, 40(4), BSR20200257.
Cai, F., Ren, F., Zhang, Y., Ding, X., Fu, G., Ren, D., ... & Zhang, H. (2021). Screening of lipid metabolism biomarkers in patients with coronary heart disease via ultra-performance liquid chromatography–high resolution mass spectrometry. Journal of Chromatography B, 1169, 122603.
Che, L., Paliogiannis, P., Cigliano, A., Pilo, M. G., Chen, X., & Calvisi, D. F. (2019). Pathogenetic, prognostic, and therapeutic role of fatty acid synthase in human hepatocellular carcinoma. Frontiers in oncology, 9, 1412.
Crudele, L., De Matteis, C., Piccinin, E., Gadaleta, R. M., Cariello, M., Di Buduo, E., ... & Moschetta, A. (2023). Low HDL-cholesterol levels predict hepatocellular carcinoma development in individuals with liver fibrosis. JHEP Reports, 5(1), 100627.
Deng, K. Q., Huang, X., Lei, F., Zhang, X. J., Zhang, P., She, Z. G., ... & Li, H. (2022). Role of hepatic lipid species in the progression of nonalcoholic fatty liver disease. American Journal of Physiology-Cell Physiology.
Khan, I. M., Gjuka, D., Jiao, J., Song, X., Wang, Y., Wang, J., ... & Beretta, L. (2021). A novel biomarker panel for the early detection and risk assessment of hepatocellular carcinoma in patients with cirrhosis. Cancer Prevention Research, 14(6), 667-674.
Kursvietiene, L., Kopustinskiene, D. M., Staneviciene, I., Mongirdiene, A., Kubová, K., Masteikova, R., & Bernatoniene, J. (2023). Anti-cancer properties of resveratrol: a focus on its impact on mitochondrial functions. Antioxidants, 12(12), 2056.
Lake, J. A., Papah, M. B., & Abasht, B. (2019). Increased expression of lipid metabolism genes in early stages of wooden breast links myopathy of broilers to metabolic syndrome in humans. Genes, 10(10), 746.
Li, S., Liu, R., Pan, Q., Wang, G., Cheng, D., Yang, J., ... & Xu, G. (2020). De novo lipogenesis is elicited dramatically in human hepatocellular carcinoma especially in hepatitis C virus-induced hepatocellular carcinoma. MedComm, 1(2), 178-187.
Lichtenstein, A. H., Appel, L. J., Vadiveloo, M., Hu, F. B., Kris-Etherton, P. M., Rebholz, C. M., ... & American Heart Association Council on Lifestyle and Cardiometabolic Health; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular Radiology and Intervention; Council on Clinical Cardiology; and Stroke Council. (2021). 2021 dietary guidance to improve cardiovascular health: a scientific statement from the American Heart Association. Circulation, 144(23), e472-e487.
Liu, H., Luo, J., Luan, S., He, C., & Li, Z. (2019). Long non-coding RNAs involved in cancer metabolic reprogramming. Cellular and Molecular Life Sciences, 76, 495-504.
Md. Tahsin Salam, Kaniz Fatema Bari et al. (2024). Emergence of Antibiotic-Resistant Infections in ICU Patients, Journal of Angiotherapy, 8(5), 1-9, 9560.
Morgan, E., Arnold, M., Camargo, M. C., Gini, A., Kunzmann, A. T., Matsuda, T., ... & Soerjomataram, I. (2022). The current and future incidence and mortality of gastric cancer in 185 countries, 2020–40: a population-based modelling study. EClinicalMedicine, 47.
Ogunwobi, O. O., Harricharran, T., Huaman, J., Galuza, A., Odumuwagun, O., Tan, Y., ... & Nguyen, M. T. (2019). Mechanisms of hepatocellular carcinoma progression. World journal of gastroenterology, 25(19), 2279.
Papah, M. B., & Abasht, B. (2019). Dysregulation of lipid metabolism and appearance of slow myofiber-specific isoforms accompany the development of Wooden Breast myopathy in modern broiler chickens. Scientific reports, 9(1), 17170.
Saravanakumar, R., Maniraj, S. P., Barshan, A. D., Das, S., Hasan, H., & Alazzam, M. B. (2023, November). Clustering big data for novel health care system. In AIP Conference Proceedings (Vol. 2587, No. 1). AIP Publishing.
Sen, B., Aggarwal, S., Nath, R., Sehgal, R., Rastogi, A., Trehanpati, N., & Ramakrishna, G. (2021). Secretome of senescent hepatoma cells modulate macrophage polarization and neutrophil extracellular traps formation. bioRxiv, 2020-12.
Shawon, M. A. A., Yousuf, M. A. K., Raheem, E., Ahmed, S., Dipti, T. T., Hoque, M. R., ... & Karim, M. R. (2020). Epidemiology, clinical features, and impact of food habits on the risk of hepatocellular carcinoma: A case-control study in Bangladesh. PLoS One, 15(4), e0232121.
Shi, T., Kobara, H., Oura, K., & Masaki, T. (2021). Mechanisms underlying hepatocellular carcinoma progression in patients with type 2 diabetes. Journal of Hepatocellular Carcinoma, 45-55.
Shu, W., Liu, L., Jiang, J., & Yao, Q. (2024). Dietary patterns and hepatocellular carcinoma risk: a systematic review and meta-analysis of cohort and case–control studies. Nutrition & Metabolism, 21.
Tan, Y. T., Lin, J. F., Li, T., Li, J. J., Xu, R. H., & Ju, H. Q. (2021). LncRNA-mediated posttranslational modifications and reprogramming of energy metabolism in cancer. Cancer Communications, 41(2), 109-120.
Tufael, Auditi Kar, Vijay Jagdish Upadhye et al., (2024). Serum Biomarkers' Significance and Gender-Specific Hepatocellular Carcinoma Insights of Fishers Patient in Bangladesh, Journal of Angiotherapy, 8(1), 1-9, 9440
Tufael, M., Upadhye, V. J., Dutta, A., Sunny, A. R., Sattar, A., Ali, M. E., ... & Hussain, M. A. (2023). Relationships between Serum Biomarkers among Hepatocellular Carcinoma Patients in Bangladeshi Fishing Communities: A Model Study.
Tufael, Md Mostafizur Rahman et al. (2024). Combined Biomarkers for Early Diagnosis of Hepatocellular Carcinoma, Journal of Angiotherapy, 8(5), 1-12, 9665
Vladu, A. F., Ficai, D., Ene, A. G., & Ficai, A. (2022). Combination therapy using polyphenols: An efficient way to improve antitumoral activity and reduce resistance. International Journal of Molecular Sciences, 23(18), 10244.
Yiasmeen, S., Karim, A. M. M. N., Begum, M., Parvin, S. I., Akter, F., Dey, S., ... & Parvez, T. M. (2020). Official Organ of Bangladesh Medical Association. Bangladesh Med J, 49(3).
Zhou, Y., Tao, J., Calvisi, D. F., & Chen, X. (2022, February). Role of lipogenesis rewiring in hepatocellular carcinoma. In Seminars in liver disease (Vol. 42, No. 01, pp. 077-086). Thieme Medical Publishers, Inc..
Zuo, D., An, H., Li, J., Xiao, J., & Ren, L. (2021). The application value of lipoprotein particle numbers in the diagnosis of HBV-related hepatocellular carcinoma with BCLC stage 0-A. Journal of Personalized Medicine, 11(11), 1143.
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