Journal of Precision Biosciences
Precision sciences | Online ISSN 3064-9226
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Contents Vol 7 (1)

Unintended Genetic Consequences of mRNA Vaccines: Evaluating Risks of Transcriptional Disruption, HLA Alteration, and Genomic Integration

Md Jabir Rashid1*, Md Sakil Amin1, Tufael2, Azizur Rahman3

+ Author Affiliations

Journal of Precision Biosciences 7 (1) 1-8 https://doi.org/10.25163/biosciences.7110287

Submitted: 06 January 2025 Revised: 08 March 2025  Published: 12 March 2025 

Abstract

The rapid advancement of mRNA technology, particularly in COVID-19 vaccines, has sparked widespread debate regarding its safety and long-term genetic implications. This study critically examines the potential risks associated with mRNA vaccines, specifically their ability to induce rogue transcriptional events that may lead to unintended genetic modifications. Contrary to initial claims that mRNA degrades harmlessly, emerging evidence suggests that synthetic sequences may embed within the human exome, disrupting essential genetic processes. The primary concern lies in the potential scrambling of the Human Leukocyte Antigen (HLA) gene complex, which could trigger autoimmune disorders and long-term genetic instability. Furthermore, the spike proteins produced by mRNA vaccines have been implicated in oxidative stress, DNA damage, and impaired cellular repair mechanisms. This study underscores the urgent need for high-resolution molecular surveillance to detect and mitigate these risks before they become permanent fixtures in the human genome. Collaborative efforts from institutions such as Neo7Bioscience, the McCullough Foundation, and the University of North Texas are pioneering RNA detection methods to assess and counteract these genetic alterations. As evidence of unintended genetic integration accumulates, a reevaluation of mRNA technology is imperative to prevent irreversible consequences for human health. The findings presented highlight the necessity for transparency, rigorous research, and ethical considerations in the deployment of genetic-based therapies.

Keywords: mRNA vaccines, rogue transcription, genetic integration, spike proteins, autoimmune disorders.

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