Significance of Serum Biomarkers in Early Diagnosis of Hepatocellular Carcinoma in Patients with Fisher Groups
Tufael 1, Auditi Kar 2, Vijay Jagdish Upadhye 3*, Amith Dutta 4, Md Royhanur Islam 5, Abdus Sattar 6, Md. Eunus Ali 7, Julakha Akter 8, Kaniz Fatima Bari 9, Md. Tahsin Salam 10, Palash Chandra Banik 11, Md Shamsuddin Sultan Khan 12, Atiqur Rahman Sunny 6*
Journal of Angiotherapy 8(1) 1-9 https://doi.org/10.25163/angiotherapy.819440
Submitted: 12 December 2023 Revised: 18 January 2024 Published: 20 January 2024
Abstract
Introduction: This study investigates the relationship between serum biomarkers and the detection of hepatocellular carcinoma (HCC) in different fisher groups in Bangladesh. The research adopts a descriptive and experimental approach to demonstrate the health risks faced by fishermen, including tobacco consumption, polluted drinking water, and insufficient sunlight exposure. Method: We used serum biomarkers such as vitamin D, alpha-fetoprotein (AFP), creatinine (Cr), and hemoglobin A1C (HbA1c) to evaluate their significance in distinguishing between different categories and sexes. Result: We determined a strong and direct correlation between insufficient vitamin D levels and an increased risk of liver cancer. The combination of AFP, vitamin D, and Cr (AFP+Vit-D+Cr) emerges as a highly predictive tool, enhancing diagnostic accuracy and providing a reliable means of identifying hepatocellular carcinoma. Conclusion: The identified correlation showed the significance of addressing lifestyle factors and promoting nutritional support to mitigate the risk of liver cancer among fisher groups. The AFP+Vit-D+Cr combination is a promising diagnostic tool for hepatocellular carcinoma, offering an improved early detection and intervention approach.
Keywords: Liver Cancer Detection, Fisher groups, Serum Biomarkers, Vitamin D Insufficiency, Health Risk Factors
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