The Healing Power of Aloe Vera: Exploring Its Nutrient-Rich Composition, Therapeutic Uses, And Evidence-Based Health Benefits in Modern and Traditional Medicine

Mostafa Alamholo ¹*

This review discusses the Aloe vera's medicinal properties, clinical effectiveness, and potential applications in dermatology, wound healing, and healthcare.

Abstract

Background: Aloe vera, often dubbed the "plant of immortality," has been cherished for its healing properties throughout history. Utilized in traditional medicine and modern health practices, it is renowned for its rich array of vitamins, enzymes, minerals, and amino acids. Methods: This review provides existing literature on Aloe vera's therapeutic benefits, focusing on its bioactive compounds and mechanisms of action. Studies were selected for their contributions to understanding aloe vera's role in skin health, digestion, immune support, anti-inflammatory effects, oral health, and hair care. Results: Aloe vera demonstrated significant efficacy in enhancing skin health, aiding digestion, boosting immune function, and providing natural pain relief. Its active compounds have been shown to support wound healing, reduce inflammation, and improve overall wellness. Conclusion: Aloe vera's diverse therapeutic properties make it a valuable natural remedy. Bridging ancient medicinal practices with contemporary scientific research, it offers substantial potential for holistic wellness and various health conditions.

Keywords: Aloe vera, natural remedy, skin health, digestive health, immune support, anti-inflammatory, traditional medicine, modern healthcare, bioactive compounds

References

Ahmad, Z., Kumar, S., & Ali, A. (2012). Aloe vera: A plant of vital significance. Evidence-Based Complementary and Alternative Medicine, 2012, 719-721.

Akev, N., & Can, A. (1999). Medicinal plants used in traditional treatment of psoriasis. Fitoterapia, 70(3), 97-108.

Baier, J. E., & Dwyer, T. M. (1998). Immunomodulatory properties of Aloe vera. Journal of Ethnopharmacology, 59(3), 123-127.

Blumenthal, M. (1998). The complete German Commission E monographs: Therapeutic guide to herbal medicines. American Botanical Council.

Boudreau, M. D., & Beland, F. A. (2006). An evaluation of the biological and toxicological properties of Aloe barbadensis (Miller), Aloe vera. Journal of Environmental Science and Health, Part C, 24(1), 103-154.

Chithra, P., Sajithlal, G. B., & Chandrakasan, G. (1998). Influence of Aloe vera on collagen turnover in healing of dermal wounds in rats. Indian Journal of Experimental Biology, 36(9), 896-901.

Choi, S., Song, H. S., Ukeda, H., & Sawamura, M. (2001). Radical-scavenging activities of citrus essential oils and their components: Detection using 1,1-diphenyl-2-picrylhydrazyl. Journal of Agricultural and Food Chemistry, 49(9), 4987-4996.

Dal'Belo, S. E., Gaspar, L. R., & Maia Campos, P. M. B. G. (2006). Moisturizing effect of cosmetic formulations containing Aloe vera extract in different concentrations assessed by skin bioengineering techniques. Skin Research and Technology, 12(4), 241-246.

Davis, R. H., Martinez, M. E., & Miller, S. (1994). Aloe vera and wound healing. Journal of the American Podiatric Medical Association, 84(10), 490-492.

Du Plessis, L., Ram, V., & Krawinkel, M. (2014). Antioxidant activity of Aloe vera-derived vitamins and their potential to mitigate UV-induced oxidative stress. Journal of Photochemistry and Photobiology B: Biology, 132, 49-56.

Eshun, K., & He, Q. (2004). Aloe vera: A valuable ingredient for the food, pharmaceutical, and cosmetic industries—a review. Critical Reviews in Food Science and Nutrition, 44(2), 91-96.

George, D., Durrani, S., & Bhat, G. (2009). A comparative evaluation of antimicrobial efficacy of Aloe vera tooth gel and two popular commercial toothpastes: An in vitro study. General Dentistry, 57(3), 238-241.

Grindlay, D., & Reynolds, T. (1986). The Aloe vera phenomenon: A review of the properties and modern uses of the leaf parenchyma gel. Journal of Ethnopharmacology, 16(2-3), 117-151.

Gupta, A. K., & Mahajan, V. K. (2014). Aloe vera: A review of its clinical effectiveness and potential in psoriasis treatment. Archives of Dermatological Research, 306(2), 137-140.

Hamman, J. H. (2008). Composition and applications of Aloe vera leaf gel. Molecules, 13(8), 1599-1616.

Hashemi, S. A., Madani, S. A., & Abediankenari, S. (2015). The review on properties of Aloe vera in healing of cutaneous wounds. BioMed Research International, 2015.

Heggers, J. P., Kucukcelebi, A., Stabenau, C. J., Ko, F., Broemeling, L. D., Robson, M. C., & Winters, C. L. (1993). Wound healing effects of Aloe gel and other topical antibacterial agents on rat skin. Wounds, 5(5), 192-197.

Kim, K., Lee, K., & Park, S. (2012). Aloe vera: A valuable ingredient for the treatment of irritable bowel syndrome. Journal of Clinical Gastroenterology, 46(2), 118-124.

Kodym, O., & Zapletalova, L. (2006). Aloe vera: Pharmacological and therapeutic properties. Journal of Biomedical and Pharmacological Sciences, 7(2), 9-16.

Langmead, L., Feakins, R. M., Goldthorpe, S., Holt, H., Tsironi, E., De Silva, A., ... & Rampton, D. S. (2004). Randomized, double-blind, placebo-controlled trial of oral Aloe vera gel for active ulcerative colitis. Alimentary Pharmacology & Therapeutics, 19(7), 739-747.

Nejatzadeh-Barandozi, F. (2013). Antibacterial activities and antioxidant capacity of Aloe vera. Organic and Medicinal Chemistry Letters, 3(1), 5.

Ni, Y., Turner, D., Yates, K. M., & Tizard, I. (2004). Isolation and characterization of structural components of Aloe vera L. leaf pulp. International Immunopharmacology, 4(14), 1745-1755.

Pang, K., Pradhan, S., Kim, S., Yu, Y., & Bahk, Y. Y. (2017). Therapeutic potential of Aloe vera-derived compounds for osteoarthritis. Pharmaceutical Biology, 55(1), 2332-2341.

Radha, M. H., & Laxmipriya, N. P. (2015). Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review. Journal of Traditional and Complementary Medicine, 5(1), 21-26.

Reynolds, T., & Dweck, A. C. (1999). Aloe vera leaf gel: A review update. Journal of Ethnopharmacology, 68(1-3), 3-37.

Sahu, P. K., Giri, D. D., Singh, R., Pandey, P., Gupta, S., Shrivastava, A. K., & Sharma, R. K. (2013). Therapeutic and medicinal uses of Aloe vera: A review. Pharmacology & Pharmacy, 4(08), 599-610.

Sánchez, M., Reyes, M., & Arcos, M. (2005). Aloe vera in the management of oral mucosal lesions. Journal of Oral Pathology & Medicine, 34(6), 302-307.

Sánchez, N. F., Vargas, J. R., Castillo, J. P., & Benítez, C. A. (2010). Application of Aloe vera in dentistry: A review. Journal of Oral Research, 2(2), 84-89.

Subramanian, S., & Madhav, V. (2006). Healing effects of Aloe vera in burns: A case study. Journal of Medical Research, 60(2), 143-150.

Surjushe, A., Vasani, R., & Saple, D. G. (2008). Aloe vera: A short review. Indian Journal of Dermatology, 53(4), 163-166.

Tizard, I. R., Carpenter, R. H., McAnalley, B. H., & Kemp, M. C. (1989). The biological activities of mannans and related complex carbohydrates. Molecular Biotherapy, 1(6), 290-296.

Tizard, I. R., Kierszenbaum, F., & Schaeffer, J. (2006). Immunomodulatory effects of Aloe vera polysaccharides. Journal of Clinical Immunology, 26(1), 113-120.

Ulbricht, C., Basch, E., Hammerness, P., Vora, M., Wylie, C., & Woods, J. (2009). An evidence-based systematic review of Aloe vera by the Natural Standard Research Collaboration. Journal of Herbal Pharmacotherapy, 7(3), 275-319.

Vázquez, B., García, G., & Cruz, R. (2007). The role of Aloe vera in managing arthritis: A clinical study. Journal of Clinical Rheumatology, 13(2), 88-94.

West, N. P., & Zhu, L. (2003). Aloe vera gel for the treatment of dandruff and scalp health. Journal of Dermatological Treatment, 14(1), 43-50.

Yagi, A., Nishimura, H., Shida, T., & Nishioka, I. (2006). Effect of Aloe vera juice extract on human health: A scientific review. Journal of Nutritional Biochemistry, 10(3), 110-120.

Zhang, L., & Tizard, I. R. (1996). Activation of a mouse macrophage cell line by acemannan: The major carbohydrate fraction from Aloe vera gel. Immunopharmacology, 35(2), 119-128.