A Systematic Review of Advanced Approaches in Wound Healing: Simvastatin Polymeric Nanoparticles and Postbiotics Innovation

Chandrapratap Dhimar ^1*, Krishna Sahu ¹, Moniza Nurez Khan ¹

Utilizing innovative postbiotics and Simvastatin Polymeric Nanoparticles, wound research accelerates healing, promising improved treatment with minimal inflammation.

Abstract

A wound is a disruption in the continuity of the skin caused by accident, disease, or surgery. Wound treatment is a vital, ongoing biologically and physiologically method that reacts to cell injury. Regarding health, economy, and social aspects, the significant impact of wounds on individuals and society underscores the need for research to identify innovative therapeutic actors that might improve the treatment of wounds.  Postbiotics, a recent addition to the biotics category, are bioactive compounds of great value generated by probiotics via metabolic processes. These substances possess various advantageous properties, such as immunomodulatory, antimicrobial, and anti-inflammatory, and promote faster wound healing. The Simvastatin Polymeric Nanoparticles (S-PNP) were synthesized utilizing the nanoprecipitation technique to enhance the solubility of the medicine and its capacity to grow the skin. The drug data, dissolution, particle dimension, charged surface, and broadcasting electron microscope of the produced S-PNP are assessed. S-PNP was applied to the hydrogel, and the physical properties, release behavior in a controlled environment, and penetration across a biological membrane of the hydrogel were assessed. The gel that had been made was administered to the wounds of rats, and a histological examination was conducted. The findings demonstrated notable effectiveness in expediting the rat wound recovery process, resulting in full epithelialization and little invasion of inflammatory cells.

Keywords: Bioactive Compounds, Wound Healing, Nanoparticles, Analysis

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