A Review of Potential Roles for Micro RNAs as Drugs Sensitivity Biomarkers in Breast Cancer

Monika Barsagade ^1*, Ravi kishore Agrawal ^2*

The role of miR-202's in discovering biomarkers for early diagnosis and improving therapeutic strategies for breast cancer.

Abstract

MiR-202, part of the let-7 family, plays a role in cell division and tumor development, especially in breast cancer (BC) among females. We have conducted a detailed review on new biomarkers to enhance BC screening and enable early diagnosis, particularly in younger women. Early detection and monitoring drug responses are crucial for optimal BC therapy, prompting the need for new biomarkers in diagnosis and prognosis. This review discusses recent findings on microRNAs in detecting, analyzing, and treating breast cancer (miRNA-BC). Although breast cancer patients often start treatment with radiotherapy, its effectiveness may decline with radiation resistance. This review study compares docetaxel-resistant breast cancer (DRBC) and docetaxel-sensitive cell lines, exploring the role of non-coding RNAs, especially circular RNAs (circRNAs), in DRBC development and identifying predictive biomarkers for taxane-containing therapies. MicroRNA sequencing and bioinformatics predict differences in microRNA expression, genes, and pathways between breast cancer cell types. Current evidence suggests that miR-202 dysregulation is linked to signaling pathways, influencing its anti- or pro-tumorigenic effects, showcasing its potential as a diagnostic biomarker.

Keywords: microRNA, breast cancer, biomarkers, drug, radio therapy

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