Therapeutic Targeting on Death Pathways in Glioblastoma

Pavithra Suppiah¹, Julia Joseph¹, Rolla Al-Shalabi¹, Nik Nur Syazni Nik Mohamed kamal¹, Nozlena Abdul Samad^1*

Abstract

Glioblastoma multiforme (GBM) is a type of aggressive glioma composed of star-shaped glial cells; it is also known as grade IV astrocytoma. Alterations are enhancing therapeutic effectiveness for individuals with glioblastoma to several targeted medicines that target cell death pathways such apoptosis (type I), autophagic cell death (type II), and necrosis (type III). The purpose of this review was to compile information about the various methods of killing cancer cells in glioblastoma and the treatments currently being used. This review aimed to determine the effectiveness of targeted therapy on glioblastoma death pathways, both intrinsic and extrinsic. Furthermore, nanoparticles studies represented a significant advance in glioblastoma via combinatorial therapy. Targeting specific proteins or genes using drug-loaded nanoparticles has promise as a treatment for glioblastoma.

Keywords:  Apoptosis; Astrocytoma; Blood-Brain Barrier; Glioblastoma; Nanoparticles.

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