Role of angiogenesis on uterine fibroids therapy: Review

Mahfoudh AL-Musali Mohammed Abdulghani

Advance research into developing experimental model to study uterine fibroid will aid in better understanding this disease.

Abstract

Anti-angiogenic agents have recently been used in the treatment of cancer in combination with chemotherapy as angiogenesis is very well documented to be a powerful control point in tumour development. The growth of uterine fibroids was recently shown to be dependent on angiogenesis and different angiogenic factors involved in uterine fibroids are expressed in leiomyoma. Uterine fibroid (uterine leiomyomas) is one of the causes of infertility and is associated with recurrent miscarriages. Pathologically uterine fibroid is a benign tumours arising from the uterine myometrial compartment. Common treatments for fibroids include pharmacotherapy and non-pharmacotherapy treatments partly via anti-angiogenic mechanisms. In conclusion, direct anti-angiogenic agents may contribute to fibroid treatment. Unfortunately, there lacks good in vivo and in vitro models of uterine fibroid. Further research into developing experimental model to study uterine fibroid will aid in better understanding this disease.

Keywords: Angiogenic Factors, Uterine Fibroids, uterine leiomyomas

References

Cramer D. (1992). Epidemiology of myomas. Semin Repro Endocrinol 10, 320–324

Everitt JI, Wolf DC, Howe SR, Goldsworthy TL, Walker C. (1995). Rodent model of reproductive tract leiomyomata. Clinical and pathological features. Am J Pathol, 146, 1556– 1567.

Fleischer R, Weston GC, Vollenhoven BJ, Rogers PAW. (2008). Pathophysiology of fibroid disease: angiogenesis and regulation of smooth muscle proliferation. Best Practice & Research Clinical Obstetrics & Gynaecology. 22(4), 603-14.

Fleischer R, Weston GC, Vollenhoven BJ, Rogers PAW. (2008). Pathophysiology of fibroid disease: angiogenesis and regulation of smooth muscle proliferation. Best Practice & Research Clinical Obstetrics & Gynaecology. 22(4), 603-14.

Georgieva B, Milev I, Minkov I, Dimitrova I, Bradford AP, Baev V. (2012). Characterization of the uterine leiomyoma microRNAome by deep sequencing. Genomics. 99(5), 275-81.

Hoffman PJ, Milliken DB, Gregg LC, Davis RR, Gregg JP. (2004). Molecular characterization of uterine fibroids and its implication for underlying mechanisms of pathogenesis. Fertility and Sterility. 82(3), 639-49.

Hoffman PJ, Milliken DB, Gregg LC, Davis RR, Gregg JP. (2004). Molecular characterization of uterine fibroids and its implication for underlying mechanisms of pathogenesis. Fertility and Sterility. 82(3), 639-49.

Howe SR, Everitt JL, Gottardis MM, Walker C. (1997). Rodent model of reproductive tract leiomyomata: Characterization and use in preclinical therapeutic studies. Prog Clin Biol Res, 396, 205– 215.

Howe SR, Gottardis MM, Everitt JI, Goldsworthy TL, Wolf DC, Walker C. (1995). Rodent model of reproductive tract leiom yomata. Establishment and characterization of tumor-derived cell lines. Am J Pathol, 146, 1568–1579.

Joseph DS, Malik M, Nurudeen S, Catherino WH. (2010). Myometrial cells undergo fibrotic transformation under the influence of transforming growth factor β-3. Fertility and Sterility, 93(5), 1500-8.

Koffuor, G. A., Annan, K., Kyekyeku, J. O., Fiadjoe, H. K., & Enyan, E. (2013). Effect of Ethanolic Stem Bark Extract of Blighia unijugata (Sapindaceae) on Monosodium Glutamate-Induced Uterine Leiomyoma in Sprague-Dawley Rats.British Journal of Pharmaceutical Research, 3(4), 880-896.

Malik M, Catherino WH. (2012). Development and validation of a three-dimensional in vitro model for uterine leiomyoma and patient-matched myometrium. Fertility and Sterility, 97(6), 1287-93.

Obochi, G. O., Malu, S. P., Obi-Abang, M., Alozie, Y., & Iyam, M. A. (2009). Effect of garlic extracts on monosodium glutamate (MSG) induced fibroid in Wistar rats. Pakistan Journal of Nutrition, 8(7), 970-976.

Ogunlabi, O. O., Adegbesan, B. O., Sumaoya, O. B., & Ajani, E. O. (2014). Modulating effects of Allium sativum (garlic) extract in monosodium glutamate induced injuries in rats. Medicinal Plants-International Journal of Phytomedicines and Related Industries, 6(1), 28-35.

Porter, K. B., Tsibris, J. C., Nicosia, S. V., Murphy, J. M., O'Brien, W. F., Rao, P. S., & Spellacy, W. N. (1995). Estrogen-induced guinea pig model for uterine leiomyomas: do the ovaries protect?. Biology of reproduction, 52(4), 824-832.

Tadakawa, M., Takeda, T., Li, B., Tsuiji, K., & Yaegashi, N. (2015). The anti-diabetic drug metformin inhibits vascular endothelial growth factor expression via the mammalian target of rapamycin complex 1/hypoxia-inducible factor-1α signaling pathway in ELT-3 cells. Molecular and cellular endocrinology, 399, 1-8.

Tsibris JCM, Maas S, Segars JH, et al. (2003). New potential regulators of uterine leiomyomata from DNA arrays: the ionotropic glutamate receptor GluR2. Biochemical and Biophysical Research Communications. 312(1), 249-54.

Vaezy, S., Fujimoto, V. Y., Walker, C., Martin, R. W., Chi, E. Y., & Crum, L. A. (2000). Treatment of uterine fibroid tumors in a nude mouse model using high-intensity focused ultrasound. American journal of obstetrics and gynecology,183(1), 6-11.

Verginadis I, Kosmas IP, Simos Y, et al. Microarray analysis in gynaecology and its findings: a systematic review. Reproductive BioMedicine, 22(6), 569-82.

Walker CL, Hunter D, Everitt JI. (2003). Uterine leiomyoma in the Eker rat: a unique model for important diseases of women. Genes, Chromosomes and Cancer. 38(4), 349-56.

Wakabayashi A, Takeda T, Tsuiji K, et al. (2011). Antiproliferative effect of adiponectin on rat uterine leiomyoma ELT-3 cells. Gynecological Endocrinology, 27(1), 33-8.

Yeung RS, Xiao GH, Everitt JI, Jin F, Walker CL. (1995). Allelic loss at the tuberous sclerosis 2 locus in spontaneous tumors in the Eker rat. Mol Carcinog, 14, 28–36

Zhang, X., Zhang, C., Shen, S., jie Xia, Y., Yi, L., Gao, Q., & Wang, Y. (2013). Dehydroepiandrosterone induces ovarian and uterine hyperfibrosis in female rats. Human Reproduction, det341.

Zia, M. S., Qamar, K., Hanif, R., & Khalil, M. (2014). Effect of monosodium glutamate on the serum estrogen and progesterone levels in female rat and prevention of this effect with diltiazem. Journal of Ayub Medical College, Abbottabad: JAMC, 26(1), 18.

Tonini T, Rossi F, Claudio PP. (2003). Molecular basis of angiogenesis and cancer. Oncogene, 22(42), 6549-56.

Makrilia N, Lappa T, Xyla V, Nikolaidis I, Syrigos K. (2009). The role of angiogenesis in solid tumours: an overview. European journal of internal medicine. 20(7), 663-71.

Baish JW, Jain RK. (2000). Fractals and cancer. Cancer research. 60(14), 3683-8.

Tal R, Segars JH. (2013). The role of angiogenic factors in fibroid pathogenesis: potential implications for future therapy. Human reproduction update, dmt042.

Ferrara N, Kerbel RS. (2005). Angiogenesis as a therapeutic target. Nature, 438(7070), 967-74.