Evaluation of Resistin Levels in Gingival Crevicular Fluid in Diabetic Patients with And without Chronic Periodontitis

Keerthidaa Govindaraj¹, Jayamathi Govindaraj^2*, S.Bhuminathan ³, Vidyarekha U⁴ and Kesavaram Padmavathy⁵, Gowtham S⁶ and Nivetha V⁶

The study represents the evaluation of resistin levels in gingival crevicular fluid in diabetic patients with and without chronic periodontitis.

Abstract

Background: Resisting, a newly identified adipocyte secreted hormone may hold a value as an inflammatory mediator, associated with insulin resistance and periodontitis. The aim of the study was to determine the resistin levels in diabetic patients with and without chronic periodontitis. Materials and Methods: A total of 80 patients (both Male and Female) participated in the study. Subjects were categorized into four groups (20 each); the group I (healthy), group II (generalized chronic periodontitis), group III (generalized chronic periodontitis without diabetes mellitus), and group IV (generalized chronic periodontitis with Diabetes Mellitus). The clinical parameters, which included plaque index (PI), gingival index (GI), probing pocket depth (PPD) and clinical attachment level (CAL), random blood sugar level (RBS), glycated haemoglobin (HbA1c) were recorded. All the assessments were performed at baseline. GCF samples were collected. Resistin was examined by utilizing a monetarily accessible ELISA unit. Contrasts among groups were statistically analysed.  Results: The expression of resisting was significantly increased between the diseased subjects when compared to healthy subjects and was statistically significant (p< 0.001). When all the samples were analyzed together, a significant positive correlation (p <0.001) was observed between GCF resistin expression, clinical parameters (GI, PI, PPD, CAL) & biochemical parameters (RBS and HbA1c). Conclusion: Resisting levels are increased in CP and T2DM. Hence, GCF resistin levels may be considered as a potential inflammatory marker for periodontitis with T2DM

Key words: Resisting, chronic Periodontitis, diabetes mellitus, gingival crevicular fluid, biomarker

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