Anti Inflammatory Activity of Mangifera Indica Peel – In Vitro Study

Bhaskaran Sathyapriya¹, Jayesh S Raghavendra², Swamikannu Bhuminathan³, Adugula Chandrakala⁴, Kesavaram Padmavathy^5*, Bharathwaj D K⁶, Indhumathi Krishnaswamy⁶

The study finds out In vitro anti-inflammatory activity of Magnifera indica peels using protein denaturation assay.

Abstract

Mangifera indica is ordinarily useful herb in ayurveda. This paper is study the  phytochemical and pharmacological activities of the herb. Various reports indicate antidiabetic, anti-oxidant, anti-viral, cardiotonic, hypotensive and anti-inflammatory properties. In addition, the other properties like antibacterial, antipyretic, antidiarrhoeal, antiallergic, immunomodulation, anti microbial, hepatoprotective, gastroprotective have been investigated. The aim of the study is to find the Invitro antiinflamtory activity of magnifera Indica peels using a protein denaturation assay. The results indicate the protein denaturation  is the  cause  of inflammation and the herb possesses different potent healthful effects.

Keywords: mangifera indica, antiinflamatory, peel, antioxidant, mango

References

Andreas S, Wieland U, Reinhold C 2000. Characterization of polyphenols in mango puree concentrate by HPLC with diode array and mass spectrometric detection. Int J Food Sci Nutr.;1:161-6.

https://doi.org/10.1016/S1466-8564(00)00015-1

Chen JP, Tai CY, Chen BH 2004. Improved liquid chromatographic method for determination of carotenoids in Taiwanese mango (Mangifera Indica L.) J Chromatogr A.;1054:261-8.

https://doi.org/10.1016/S0021-9673(04)01406-2

Desai PD, Ganguly AK, Govindachari TR, Joshi BS, Kamat VN, Manmade AH, et al 1966. Chemical investigation of some Indian plants: Part II. Indian J Chem.;4:457-549.

Diplock AT, Charleux JL, Crozier-Willi G, Kok FJ, Rice-Evans C, Roberfroid M, et al 1998. Functional food science and defense against reactive oxidative species. Br J Nutr. ;80:S77-112. [PubMed]

https://doi.org/10.1079/BJN19980106

Gabino G, Deyarina G, Cheyla R, Nunez-Selles AJ, Rene D 2008. Scavenger effect of a mango (Mangifera indicaL.) food supplement's active ingredient on free radicals produced by human polymorphonuclear cells and hypoxanthine-xanthine oxidase chemiluminescence systems. Food Chem. ;107:1008-14.

https://doi.org/10.1016/j.foodchem.2007.09.012

Khan MA, Khan MN 1989. Alkyl gallates of flowers of Mangifera Indica. Fitoterapia.;60:284.

Khan MN, Nizami SS, Khan MA, Ahmed Z 1993. New saponins from Mangifera Indica. J Nat Prod.;56:767-70.

https://doi.org/10.1021/np50095a016

Khan MN, Nizami SS, Khan MA, Ahmed Z. New saponins from Mangifera Indica. J National Scartezzini P, Speroni E 2000. Review on some plants of Indian traditional medicine with antioxidant activity. J Ethnopharmacol.;71:23-43. [PubMed]

https://doi.org/10.1016/S0378-8741(00)00213-0

Knödler M, Berardini N, Kammerer DR, Carle R, Schieber A 2007. Characterization of major and minor alk(en)ylresorcinols from mango (Mangifera Indica L.) peels by high-performance liquid chromatography/atmospheric pressure chemical ionization mass spectrometry. Rapid Commun Mass Spectrom.;21:945-51.

https://doi.org/10.1002/rcm.2919

Martinez G, Delgado R, Perez G, Garrido G, Nunez Selles AJ, Leon OS 2000. Evaluation of the in-vitroantioxidant activity of Mangifera indica L: Extract (Vimang) Phytother Res. ;14:424-7. [PubMed]

https://doi.org/10.1002/1099-1573(200009)14:6<424::AID-PTR643>3.0.CO;2-8

Maxwell SR 1997. Anti oxidant therapy: Does it have a role in the treatment of human disease? Expert Opin Investig Drug. ; 6:211-36. [PubMed]

https://doi.org/10.1517/13543784.6.3.211

Muruganandan S, Gupta S, Kataria M, Lal J, Gupta PK 2002. Mangiferin protects the streptozotocin-induced oxidative damage to cardiac and renal tissues in rats. Toxicology.;176:165-73.

https://doi.org/10.1016/S0300-483X(02)00069-0

Nunez Selles AJ, Vélez Castro HT, Agüero-Agüero J, Gonzalez-Gonzalez J, Naddeo F, De Simone F, et al 2002. Isolation and quantitative analysis of phenolic antioxidants, free sugars, and polyols from Mango (Mangifera Indica L.) stem bark aqueous decoction used in cuba as a nutritional supplement. J Agric Food Chem.;50:762-6.

https://doi.org/10.1021/jf011064b

Ornelas-Paz Jde J, Yahia EM, Gardea-Bejar A 2007. Identification and quantification of xanthophyll esters, carotenes, and tocopherols in the fruit of seven Mexican mango cultivars by liquid chromatography-atmospheric pressure chemical ionization-time-of-flight mass spectrometry [LC-(APcI(+))-MS] J Agric Food Chem.;55:6628-35.

https://doi.org/10.1021/jf0706981

Pardo Andreu G, Delgado R, Velho J, Inada NM, Curti C, Vercesi AE2005. Mangifera Indica L.extract (Vimang) inhibits Fe2+- citrate-induced lipoperoxidation in isolated rat liver mitochondria. Pharmacol Res. ;51:427-35.[PubMed]

https://doi.org/10.1016/j.phrs.2004.11.002

Pardo-Andreu GL, Sanchez-Baldoquín C, Avila-González R, Yamamoto ET, Revilla A, Uyemura SA, et al 2006. Interaction of Vimang (Mangifera indica L.extract) with Fe(III) improves its antioxidant and cytoprotecting activity. Pharmacol Res. ;54:389-95. [PubMed]

https://doi.org/10.1016/j.phrs.2006.08.001

Pott I, Marx M, Neidhart S, Mühlbauer W, Carle R 2003. Quantitative determination of beta-carotene stereoisomers in fresh, dried, and solar-dried mangoes (Mangifera Indica L.) J Agric Food Chem.;51:4527-31.

https://doi.org/10.1021/jf034084h

Rocha Ribeiro SM, Queiroz JH, Lopes Ribeiro ME, Campos FM, Pinheiro Santana HM 2007. Antioxidant in mango (Mangifera indica L.) pulp. Plant Foods Hum Nutr. ;62:13-7. [PubMed]

https://doi.org/10.1007/s11130-006-0035-3

Ross IA. Vol. 1. New Jersey Totowa: Human Press; 1999. Medicinal plants of the world; pp. 199-200.

Sanchez GM, Re L, Giuliani A, Nuñez-Selles AJ, Davison GP, Leon-Fernandez OS 2000. Protective effects of Mangifera indica L.extract, mangiferin and selected antioxydants against TPA-induced biomolecules oxidation and peritoneal macrophage activation in mice. Pharmacol Res. ;42:565-73. [PubMed]

https://doi.org/10.1006/phrs.2000.0727

Scartezzini P, Speroni E. 2000. Review on some plants of Indian traditional medicine with antioxidant activity. J Ethnopharmacol.;71:23-43.

https://doi.org/10.1016/S0378-8741(00)00213-0

Seifried HE, Anderson DE, Fisher EI, Milner JA2007. A review of the interaction among dietary antioxidants and reactive oxygen species. J Nutr Biochem. ; 18:567-79. [PubMed]

https://doi.org/10.1016/j.jnutbio.2006.10.007

Shankarnarayanan D, Gopalakrishman C, Kameswaran L, Arumugum S 1979. The effect of mangostin, mangostin-3, 6-di-O-glucoside and Mangiferin in carbon tetrachloride liver injury. Mediscope.;22:65.

Shibahara A, Yamamoto K, Shinkai K, Nakayama T, Kajimoto G 1993. Cis-9, cis-15-octadecadienoic acid:a novel fatty acid found in higher plants. Biochimi Biophy Acta.;1170:245-52.

https://doi.org/10.1016/0005-2760(93)90006-U

Subbarayan C, Cama HR 1966. Isolation & characterization of a carotenoid-protein complex from Mangifera indica(mango) Indian J Biochem. ; 3:225-7. [PubMed]

Subha R, Pandey MM, Singh AK 2007. A new, convenient method for determination of mangiferin: An anti-diabetic compound, in Mangifera Indica L. J Planar Chromatogr.;20:317-320.

https://doi.org/10.1556/JPC.20.2007.5.1