Integrative Biomedical Research
Integrative Biomedical Research (Journal of Angiotherapy) | Online ISSN 3068-6326
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Volume 6 Number 2 2022
REVIEWS (Open Access)
A Systematic Review on Temporal Lobe Epilepsy Patients with Corona Virus Infection
Pugazhandhi Bakthavatchalam1, Fouad Saleih R.AL-Suede2,3, Sudarshan S.1*
Journal of Angiotherapy 6 (2) 632-636 https://doi.org/10.25163/angiotherapy.6221312825042022
Submitted: 25 September 2021 Revised: 28 February 2022 Published: 04 March 2022
Abstract
Objective: To systematically review the neurological symptoms and complications in temporal lobe epilepsy patients with Coronavirus infected patients. Methods: A systematic review of clinical studies on cases with neurological symptoms linked to COVID-19 and other coronaviruses was conducted. Following the PRISMA guidelines, a search for related scientific publications was performed in the following electronic databases: PubMed, Scopus, and Embase. The keywords used were “coronavirus" or "Sars-CoV-2" or "COVID-19" and "neurologic manifestations" or "neurological symptoms" or "meningitis" or "encephalitis" or "encephalopathy." Results: A total of 43 articles varying from case reports to case series, cohort studies, and systematic reviews were examined on SARS-CoV-2 and other human coronavirus infections with clinical symptoms in the central nervous system. Hyposmia, headaches, weakness, and altered awareness were among the most commonly reported symptoms. COVID-19 has been linked to encephalitis, demyelination, neuropathy, and stroke. Infection via the cribriform plate of the ethmoidal bone and olfactory bulb, as well as trans-synaptic transmission, are some of the proposed mechanisms. Invasion of the medullary cardiorespiratory center by SARS-CoV-2 may have a role in the refractory respiratory failure seen in corona virus-infected patients who are critically ill. Conclusion: Coronaviruses have a high potential to damage the central nervous system and can cause a variety of neurological symptoms, from moderate to severe. cephalalgy, lightheadedness, and altered level of consciousness were the most common neurological functional and structural signs discovered.
Keywords: COVID-19, SARS-CoV-2HCoVSARS, Middle East respiratory syndrome coronavirus (MERS-CoV), Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Neurological manifestation, Encephalopathy
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