Effect of Parasteron on In Vivo Atherosclerotic model with Functional and Tissue Damage Mitigation

Ghfran Adnan Abdul Amir ^1*, Batool A. Hussein ²

Parasteron reduces atherosclerosis-related damage, suggesting potential as a therapeutic agent in managing cardiovascular disease.

Abstract

Background: Atherosclerosis, a leading cause of cardiovascular diseases, involves the buildup of plaques within arterial walls, leading to functional and tissue damage. Animal models, particularly rabbits, have been instrumental in studying this disease due to their lipoprotein metabolism and sensitivity to a cholesterol diet, similar to humans. The current study aims to evaluate the effects of the steroid hormone parasteron on the functional and tissue damage caused by atherosclerosis in adult female rabbits. Methods: The study was conducted over six weeks on four groups of adult female rabbits. The first group served as the control, while the second group was administered cholesterol to induce atherosclerosis. The third and fourth groups were treated with both cholesterol and the steroid hormone parasteron. Various parameters related to atherosclerosis, including functional metrics and tissue damage, were monitored and analyzed. Results: The control group showed no signs of atherosclerosis or tissue damage. The cholesterol-only group exhibited significant functional impairments and tissue damage characteristic of atherosclerosis. In the groups treated with parasteron, there was a notable reduction in both functional impairments and tissue damage compared to the cholesterol-only group. The extent of protection provided by parasteron was assessed through histological and biochemical analyses, which revealed a marked improvement in arterial health and function. Conclusion: The administration of parasteron significantly mitigates the functional and tissue damage associated with atherosclerosis in adult female rabbits. These findings suggest the potential of parasteron as a therapeutic agent in the management of atherosclerosis. Further research is warranted to explore the underlying mechanisms and to evaluate the long-term efficacy and safety of parasteron in larger clinical settings.

Keywords: Atherosclerosis, Parasteron, Cardiovascular health, Steroid hormone, Animal model

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