Angiogenesis, Inflammation & Therapeutics | Impact 0.1 (CiteScore) | Online ISSN  2207-872X
RESEARCH ARTICLE   (Open Access)

Fenugreek Induces The Sperm Characteristics in Hypothyroid Male Rats

Fouad Ziedan Hamza Al-Quraishi 1*, Bassam Abdulameer Mohammed Al-Madany 1*, Mohammed Abdaljaleel Fadhel Al-Kraawi 1, Zainab Mohammed Kadhim Hirzuldeen 1, Karrar Talib Salman Al-Ibrahimi 1

+ Author Affiliations

Journal of Angiotherapy 8(5) 1-6 https://doi.org/10.25163/angiotherapy.859684

Submitted: 26 March 2024  Revised: 19 May 2024  Published: 21 May 2024 

This study demonstrated fenugreek's potential to improve sperm quality and hormone levels in hypothyroid male rats, suggesting therapeutic benefits.

Abstract


Background: Hypothyroidism, a common thyroid dysfunction, disrupts the neuroendocrine axis, affecting testicular function. Fenugreek (Trigonella foenum-graecum L.), a traditional herbal remedy, is known for its anti-diabetic and hypocholesterolemic effects but may also impact fertility. This study investigates the effects of fenugreek on sperm characteristics in hypothyroid male rats. Methods: Forty male rats were divided into four groups: control, hypothyroid control, hypothyroid with fenugreek (15 mg/kg B.W.), and hypothyroid with L-T4 (0.1 mg/kg/day). Hypothyroidism was induced with 0.05% 6-propyl-thiouracil in drinking water for 30 days. Thyroid hormones (TSH, T3, T4) and sperm parameters (motility, viability, morphology) were analyzed post-treatment. Results: Hypothyroid rats showed significantly increased TSH and decreased T3 and T4 levels compared to controls. Treatment with fenugreek or L-T4 significantly reduced TSH and increased T3 and T4 levels. Both treatments also improved sperm motility, viability, and morphology compared to hypothyroid controls. Conclusion: Fenugreek ameliorates the adverse effects of hypothyroidism on thyroid hormone levels and sperm characteristics in male rats, suggesting its potential as a therapeutic agent for managing hypothyroidism-related fertility issues. Further research is warranted to explore the underlying mechanisms and long-term effects of fenugreek supplementation.

Keywords: Thyroxine, Fenugreek, hypothyroidism, sperm quality, male fertility, thyroid hormones

References


Somaya M. Eshtiwi. (2024). Treatment of Hypothyroidism with Flavonoid Rich Extract of Fucus vesiculosus L Algae in Adult Rats, Journal of Angiotherpay, 8(3), 1-10, 9530

Vinay Jaiswal, Prachi Gurudiwan. (2023). Identifying Thyroid Dysfunction Using Standard Laboratory Testings – A Systematic Review, Journal of Angiotherapy, 7(2), 1-8, 9409.

Srivalsa Bhaskaran, Kamaal Mohideen Khan, Karthik V, Mani Shanthini, (2021), Hypothyroidism Presenting as Reversible Renal Impairment, Journal of Angiotherapy, 5(2), 2161

A.S. Abdul Majid, Elham Farsi, N.Vijayalakshmi, S.A. Syed Amran, M.M. Kanakal, Z.T.Zainudeen. (2019). Evaluation of Safety and Efficacy of Labeesity® for Weight Management and Fatigue in an Obese Female Patient with Hypothyroidism: A Case Report, Journal of Angiotherapy, 3(1), pp. 132-137

Full Text
Export Citation

View Dimensions


View Plumx



View Altmetric



0
Save
0
Citation
311
View
0
Share