Embryotoxicity, Teratogenicity, and Chronic Toxicity of a Medicinal Balm with Adaptogenic Effects

Z.T. Fayzieva ^1*, M. M. Rakhmatullayeva ¹, G.O. Rakhimova ¹, A.J.Rajapov ¹, D. M. Hashirbaeva ¹

Investigates medicinal balm's safety, showing no embryotoxic, teratogenic effects, or chronic toxicity, supporting its use in complex therapy.

Abstract

Background: The body's ability to adapt to changing internal and external environmental conditions is crucial for maintaining homeostasis. Disruptions in adaptive mechanisms can lead to pathological conditions such as chronic heart failure and cerebrovascular insufficiency. Adaptogenic drugs, which enhance the body's resistance to adverse factors, are utilized in various therapeutic contexts. This study investigates the teratogenic, embryotoxic effects, and chronic toxicity of a medicinal balm with adaptogenic properties. Methods: The medicinal balm was prepared by maceration in 70% ethyl alcohol, followed by filtration and blending with natural honey. Teratogenic and embryotoxic effects were studied using 50 pregnant white laboratory rats and approximately 200 newborn rat fetuses. Chronic toxicity was assessed with 30 rats and 12 rabbits, which received the balm at doses of 50 mg/kg and 100 mg/kg orally for a month. Control groups received saline. Parameters studied included peripheral blood, biochemical markers, organ histology, body weight, and temperature. Results: The balm at therapeutic doses led to a 6.8% increase in body weight of pregnant rats without affecting fetal development or causing pathological forms. Histological analysis showed normal development of internal organs in both control and experimental groups. Chronic toxicity tests revealed no significant changes in blood parameters, body weight, or body temperature. Histological examination of internal organs showed no signs of dystrophic or destructive changes. Conclusion: The medicinal balm does not exhibit teratogenic or embryotoxic effects and does not induce chronic toxicity. It maintains normal biochemical and hematological blood parameters and does not alter the histostructure of organs with prolonged administration. These findings support the safety of the balm for potential therapeutic use.

Keywords: Adaptogenic drugs, Chronic toxicity, Embryotoxicity, Teratogenicity, Medicinal balm

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