HDL Cholesterol And Female Infertility: Lessons From Animal Models

Anastasia V. Poznyak ^1*, Igor A. Sobenin ², Victor Y Glanz ², Victoria A. Khotina ², Vasily N. Sukhorukov ¹, and Alexander N. Orekhov ¹

This review describes HDL metabolism's role in oocyte quality and female fertility offers insights for targeted interventions and personalized treatments in reproductive medicine.

Abstract

Cholesterol metabolism, particularly the role of high density lipoprotein (HDL), plays a critical role in female fertility. This review examines the implications of HDL metabolism on various aspects of female reproduction using animal models, including ABCA1 KO mice, SCARB1 KO mice, a restricted ovulator chicken mutant model, and liver X receptor KO mice. The paper highlights the importance of HDL in oocyte development, embryo quality, and overall reproductive outcomes. By summarizing the findings from these models, significant insights into the mechanisms behind dysfunctional HDL metabolism and its impact on female infertility are revealed. The methodology employed in this review includes a systematic analysis of literature and data from studies on animal models, providing a comprehensive understanding of the complex relationship between HDL cholesterol and female reproductive health.

Keywords: Cholesterol, Lipoproteins, HDL Metabolism, Animal Models, Female Infertility

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