Advancing Lotion Formulation Research: Harnessing the Potential of Moringa oleifera and Shea Butter for Enhanced Skin Health

Rolla Al-Shalabi ^1,2, Nozlena Abdul Samad ^1*, Lim Vuanghao ¹, Julia Joseph ¹

The integration of Moringa oleifera nanoparticles and shea butter in lotion represents a groundbreaking milestone in skincare. This fusion offers profound benefits, including deep hydration and potent anti-inflammatory properties.

Abstract

Background: Recent advancements have highlighted the potential of Moringa oleifera nanoparticles in enhancing UV protection, skin absorption, efficacy, and skincare formulations. This study aimed to develop a lotion incorporating Moringa oleifera nanoparticles to synergize its benefits with nanotechnology for improved UV defense and skin permeability. Method: Nanoparticles were extracted through a sequential process, resulting in silver nanoparticle synthesis. The lotion comprised three phases: oily (emulsifying wax, shea butter), water (distilled water, kaolin, Moringa oleifera nanoparticle extract), and additive (benzoic acid, fragrance), formulated using a double-boil technique. Quality and longevity were assessed via pH and centrifugal stability tests. The formulated lotion exhibited appealing aesthetics, high moisture content, improved texture, inflammation reduction, and effective hydration. Stability tests confirmed its quality. Results: The lotion holds significant potential for skin hydration and repair, though further research, including animal models and clinical trials, is necessary for validation. Conclusion: This study emphasizes the promising use of Moringa oleifera nanoparticles in advanced skincare solutions.

Keywords: Lotion Formulation, Moringa oleifera, Shea Butter, Skin Health

References

Banerjee, P., kumar Dey, T., Sarkar, S., Swarnakar, S., Mukhopadhyay, A., & Ghosh, S. (2016). Treatment of cosmetic effluent in different configurations of ceramic UF membrane based bioreactor: Toxicity evaluation of the untreated and treated wastewater using catfish (Heteropneustes fossilis). Chemosphere, 146, 133-144.

Calixto, L. S., Infante, V. H. P., & Maia Campos, P. M. (2018). Design and characterization of topical formulations: correlations between instrumental and sensorial measurements. Aaps Pharmscitech, 19, 1512-1519.

Contado, C. (2022). Particle characterization: parameters and selected methods. In Particle Separation Techniques (pp. 63-114). Elsevier.

Fransiska, D., Darmawan, M., Sinurat, E., Sedayu, B. B., Wardhana, Y. W., Herdiana, Y., & Setiana, G. P. (2021, March). Characteristics of Oil in Water (o/w) Type Lotions Incorporated with Kappa/Iota Carrageenan. In IOP Conference Series: Earth and Environmental Science (Vol. 715, No. 1, p. 012050). IOP Publishing.

Gerstler, W. D., Barua, A., Huang, S., Erno, D. J., Wang, Y., Ju, S., & Thiagarajan, N. (2023). Binder Jet Additive Manufacturing Process and Material Characterization for High Temperature Heat Exchangers Used in Concentrated Solar Power Applications. Metals, 13(3), 617.

Hanifah, M., & Jufri, M. (2018). Formulation and stability testing of nanoemulsion lotion containing centella asiatica extract. Journal of young pharmacists, 10(4), 404.

Hassan, M. A., Xu, T., Tian, Y., Zhong, Y., Ali, F. A. Z., Yang, X., & Lu, B. (2021). Health benefits and phenolic compounds of Moringa oleifera leaves: A comprehensive review. Phytomedicine, 93, 153771.

Israel, M. O. (2015). Shea butter: An opposite replacement for trans-fat in margarine. Journal of Nutrition & Food Sciences, (S11), 1.

Leal, G. C., da Costa, I. M., da Silva, J. B., dos Santos, R. S., Bruschi, M. L., de Mello, J. C. P., ... & Lonni, A. A. S. G. (2022). Development, characterization, and evaluation by cutaneous bioengineering of a natural emulsion, to provide a standardized vehicle base for topical compounded preparations. Research, Society and Development, 11(16), e509111638290-e509111638290.

Maanikuu, P. M. I., & Peker, K. (2017). Medicinal and nutritional benefits from the shea tree (Vitellaria paradoxa). Journal of Biology Agriculture and Healthcare, 7(22), 51-57.

Mittal, A. K., Chisti, Y., & Banerjee, U. C. (2013). Synthesis of metallic nanoparticles using plant extracts. Biotechnology advances, 31(2), 346-356.

Rádis-Baptista, G. (2023). Do Synthetic Fragrances in Personal Care and Household Products Impact Indoor Air Quality and Pose Health Risks? Journal of Xenobiotics, 13(1), 121-131.

Restu, W. K., Sampora, Y., Meliana, Y., & Haryono, A. (2015). Effect of accelerated stability test on characteristics of emulsion systems with chitosan as a stabilizer. Procedia Chemistry, 16, 171-176.

Senanayake, S. N. (2013). Green tea extract: Chemistry, antioxidant properties and food applications–A review. Journal of functional foods, 5(4), 1529-1541.

SHITOLE, S., SHINDE, S., WAGHMARE, S., & KAMBLE, H. (2022). A Review On: Preservatives Used in Pharmaceuticals and Impacts on Health. IRE J, 5(7), 131-40.

Singal, M., Vitale, D., & Smith, L. (2011). Fragranced products and VOCs. Environmental health perspectives, 119(5), A200-A200.

Souto, E. B., Yoshida, C. M., Leonardi, G. R., Cano, A., Sanchez-Lopez, E., Zielinska, A., ... & Barbosa, R. D. M. (2021). Lipid-polymeric films: Composition, production and applications in wound healing and skin repair. Pharmaceutics, 13(8), 1199.

Süntar, I. (2020). Importance of ethnopharmacological studies in drug discovery: role of medicinal plants. Phytochemistry Reviews, 19(5), 1199-1209.

Vergara-Jimenez, M., Almatrafi, M. M., & Fernandez, M. L. (2017). Bioactive components in Moringa oleifera leaves protect against chronic disease. Antioxidants, 6(4), 91.

Wiechers, J. W., & Musee, N. (2010). Engineered inorganic nanoparticles and cosmetics: facts, issues, knowledge gaps and challenges. Journal of biomedical nanotechnology, 6(5), 408-431.

Xiao, X., Wang, J., Meng, C., Liang, W., Wang, T., Zhou, B., ... & Zhang, L. (2020). Moringa oleifera Lam and its therapeutic effects in immune disorders. Frontiers in pharmacology, 2188.

Meirkhanova, A. M., Myrzabayeva, M. B., & Karaubayeva, A. A. (2019). Cosmetic anti-inflammatory facial mask based on kaolin. Bulletin of the Kazakh National Medical University, (1), 459-461.