Green Synthesis, Lead Toxicity and Pharmacokinetic Evaluation of Sumac Silver Nanoparticles In Vivo

Ammar H. Salman ^1*, Mohammed Mosleh Shwaish ¹

Sumac-synthesized silver nanoparticles (SAgNP) showed an eco-friendly approach to reduce blood lead levels, promising safer, cost-effective lead detoxification.

Abstract

Sumac (Rhuscoriaria L., family Anacardiaceae) is rich in bioactive components like tannins and phenolic compounds, exhibiting antioxidant properties. Green synthesis of silver nanoparticles (SAgNP) offers eco-friendly and cost-effective production methods. In this study, the effect of Sumac nano silver particles (SAgNP) on lead pharmacokinetics was assessed. Green synthesis of silver nanoparticles involved adding 25 ml of sumac extract to 200 ml of 1 mM silver nitrate solution under hot stirring. Twenty-one male albino rats were randomly divided into three groups: lead group (60 mg/kg of lead acetate orally), crude group (100 mg/kg of crude sumac extract orally), and nano group (100 mg/kg of SAgNP orally followed by lead acetate). Results demonstrated successful SAgNP formation and significant reduction (p≤0.05) in blood lead concentration after 6 hours, suggesting SAgNP's potential in lowering lead levels. SAgNP exhibited stronger efficacy than crude extract in reducing blood lead concentrations. Green synthesis of silver nanoparticles offers a safe, cost-effective, and environmentally friendly approach with promising applications in mitigating lead toxicity.

Keywords: Sumac, Silver nanoparticles, Green synthesis, Pharmacokinetics, Lead toxicity

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