A Study of Biochemical Markers in Uterine Cancer Diagnosis with Radiotherpay Treatment In Iraq

Wael Sahib Alnweny ^1*, Mohammed Q. Almayali ^1*, Mohammed A. Dakhil ², Hiba Ali Numan ¹, Yasir J. Abbas ³

Effect and investigation of radiotherapy of clinical biomarkers in Uterine Cancer patients.

Abstract

Background: Uterine cancer is a prevalent gynecological malignancy, with rising incidence rates globally. Early detection and effective treatment are essential for improving patient outcomes. Biochemical markers play a crucial role in diagnosing and monitoring uterine cancer, yet their comprehensive evaluation remains limited. Methods: This study aimed to assess various biochemical markers in the serum of uterine cancer patients compared to healthy individuals. Serum samples from 30 uterine cancer patients and 40 healthy females were analyzed for urea, creatinine, lactate dehydrogenase (LDH) activity, antioxidants (vitamin C and vitamin E), peroxynitrite, and trace elements (calcium and zinc). Results: The study revealed a significant decrease in urea and creatinine levels in serum of uterine cancer patients compared to healthy individuals (p≤0.05). During radiotherapy, blood urea nitrogen (BUN) exceeded the normal range (7-20 mg/dl), averaging 25.44 ± 9.87 mg/dl before treatment initiation, with no significant decrease during therapy. Serum creatinine levels remained within the normal range. Additionally, a significant reduction in serum vitamin C and vitamin E levels was observed in uterine cancer patients compared to healthy individuals (p≤0.05). Moreover, there was a significant increase in peroxynitrite and lactate dehydrogenase (LDH) activity, along with a rise in serum calcium levels, and a significant decrease in serum zinc levels among uterine cancer patients (p≤0.05). Conclusion: The findings highlight the significance of assessing multiple biochemical markers in uterine cancer diagnosis and monitoring. Elevated LDH, peroxynitrite, and calcium levels, along with reduced vitamin C, vitamin E, and zinc levels, may serve as valuable diagnostic markers for uterine cancer.

Keywords: Radiotherapy; Biochemical parameters; Uterine Cancer, Diagnosis, Risk Factors, Treatment

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