Advances in Cellular Models of Atherosclerosis

Anastasia V. Poznyak ^1*, Victoria A. Khotina ², Victor Y Glanz ², Alexander L Golovyuk ³, Dmitriy Yu Serdyukov ⁴, Vasily N. Sukhorukov ¹, Igor Alexandrovich Sobenin ², Alexander N. Orekhov ¹

Atherosclerosis models, from 2D cultures to 3D tissue-engineered vessels, offer cost-effective avenues for drug screening and personalized medicine, advancing therapeutic discovery.

Abstract

Atherosclerosis is a disease with a complex pathogenesis, consisting of the interrelationships of many different elements. In light of the increasing spread of cardiovascular diseases, the precursor of which is atherosclerosis, the study of the intricacies of its pathogenesis remains an important research task. For its achievement, it is necessary to choose the right model. To date, the most common are models of small animals, in particular mice. However, extensive work is being carried out towards the development of cellular models that would allow moving away from the use of animals as model objects, as well as bypassing the problems of translating the results. In this review, we collected data on the current advances in the field of cellular models of atherosclerosis.

Keywords: Cellular models; In Vitro models; Atherosclerosis.

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