The Role of Natural Compounds for Atherosclerosis Treatment: Lessons Learned from The Use of Curcumin

Anastasia V. Poznyak ^1*, Victoria A. Khotina ², Roghayyeh Vakili-Ghartavol ³, Alexander L Golovyuk ⁴, Dmitriy Yu Serdyukov ⁵, Victor Y Glanz ², Vasily N. Sukhorukov ², Alexander N. Orekhov ^2*

Curcumin has various pharmacological effects on atherosclerosis. This review discussed the promising therapeutic potential, of curcumin as anti-inflammatory, lipid regulation, and endothelial function for cardiovascular disease.

Abstract

Relationships between the occurrence of various diseases that have certain similarities are of particular interest to scientists and clinicians. On the one hand, such an analysis can help to better understand the underlying mechanisms and, on the other hand, to cope with the disease/diseases more effectively. In this review, we look at the relationship between NAFLD and atherosclerosis. The main and obvious intersection in their pathogenesis is, of course, lipid metabolism disorders. However, this is not the only relationship. In addition to the similarity of pathogenesis, we considered the possibility of one disease to serve as a risk factor for the development of the second. We devoted a separate chapter to the methods of treatment of these two pathologies.

Keywords: Curcumin; Natural compound; Phytotherapy; Atherosclerosis; Cardiovascular disease.

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