Oxidative Stress: Insights into Nutrition, Psychological Stress, Environmental Exposure, and Antioxidants Roles

Iza Safany Che Hanafi ¹, Chandrarohini Saravanan ², Rabiatul Basria S. M. N. Mydin ^2*

This review discusses how oxidative stress affects our bodies due to factors like diet, stress, and environment, and how antioxidants help. Understanding this is crucial for fighting diseases like cancer and staying healthy.

Abstract

This comprehensive review describes the intricate realms of oxidative stress, examining its origins in nutrition, psychological stress, environmental exposures, and the vital roles of antioxidants. Nutritional factors, particularly macronutrients and dietary elements, play a dual role in either inducing or preventing oxidative stress, with implications for inflammation, metabolic disorders, and carcinogenesis. The exploration extends to the profound impact of psychological stress, highlighting oxidative imbalance as a "new stress" linked to various diseases, including psychiatric disorders. Environmental exposures, encompassing pollutants and UV radiation, contribute significantly to oxidative stress, emphasizing the need for a comprehensive understanding of these mechanisms. The role of endogenous and exogenous antioxidants is crucial in neutralizing free radicals and maintaining redox homeostasis. This thorough analysis provides insights into potential interventions and underscores the complex relationships between oxidative stress, antioxidants, and human health.

Keywords: Oxidative stress, reactive oxygen species, free radicals, nutritional, cancer, disease, antioxidant, dietary

References

Anon. (2020). Distinguishing benign and malignant growth _ EdCaN (p. 1). Australia Goverment Cancer Australia.

Aseervatham, G. S. B., Sivasudha, T., Jeyadevi, R., & Arul Ananth, D. (2013). Environmental factors and unhealthy lifestyle influence oxidative stress in humans--an overview. In Environmental science and pollution research international (Vol. 20, Issue 7, pp. 4356–4369). https://doi.org/10.1007/s11356-013-1748-0

Bouayed, J., & Bohn, T. (2010). Exogenous antioxidants - Double-edged swords in cellular redox state: Health beneficial effects at physiologic doses versus deleterious effects at high doses. In Oxidative Medicine and Cellular Longevity (pp. 228–237). https://doi.org/10.4161/oxim.3.4.12858

Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians, 68(6), 394-424.

Cooper, G. M., & Hausman, R. E. (2007). The Development and Causes of Cancer. The Cell: A Molecular Approach. https://doi.org/10.1016/j.pbb.2009.09.001

Davis, C. D., Tsuji, P. A., & Milner, J. A. (2012). Selenoproteins and Cancer Prevention. Annual Review of Nutrition, 32, 73–95. https://doi.org/10.1146/annurev-nutr-071811-150740

de Jager, T. L., Cockrell, A. E., & Du Plessis, S. S. (2017). Ultraviolet light induced generation of reactive oxygen species. In Advances in Experimental Medicine and Biology (Vol. 996, pp. 15–23). Springer New York LLC. https://doi.org/10.1007/978-3-319-56017-5_2

Diamanti-Kandarakis, E., Papalou, O., Kandaraki, E. A., & Kassi, G. (2017). Nutrition as a mediator of oxidative stress in metabolic and reproductive disorders in women. In European Journal of Endocrinology (Vol. 176, Issue 2, pp. R79–R99). BioScientifica Ltd. https://doi.org/10.1530/EJE-16-0616

Gandhi, S., & Abramov, A. Y. (2012). Mechanism of oxidative stress in neurodegeneration. In Oxidative Medicine and Cellular Longevity (pp. 1–11). Hindawi Limited. https://doi.org/10.1155/2012/428010

Gassman, N. R. (2017). Induction of oxidative stress by bisphenol A and its pleiotropic effects. In Environmental and Molecular Mutagenesis (Vol. 58, Issue 2, pp. 60–71). John Wiley and Sons Inc. https://doi.org/10.1002/em.22072

Jia, Q. Q., Wang, J. C., Long, J., Zhao, Y., Chen, S. J., Zhai, J. D., Wei, L. B., Zhang, Q., Chen, Y., & Long, H. B. (2013). Sesquiterpene lactones and their derivatives inhibit high glucose-induced NF-κB activation and MCP-1 and TGF-β1 expression in rat mesangial cells. Molecules, 18(10), 13061–13077. https://doi.org/10.3390/molecules181013061

Koju, N., Taleb, A., Zhou, J., Lv, G., Yang, J., Cao, X., Lei, H., & Ding, Q. (2019). Pharmacological strategies to lower crosstalk between nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and mitochondria. In Biomedicine and Pharmacotherapy (Vol. 111, pp. 1478–1498). Elsevier Masson SAS. https://doi.org/10.1016/j.biopha.2018.11.128

Kresser, C. (2018). What really causes oxidative damage. In Kresser Institute (p. 1).

Krishnamoorthy, G., Selvakumar, K., Venkataraman, P., Elumalai, P., & Arunakaran, J. (2013). Lycopene supplementation prevents reactive oxygen species mediated apoptosis in Sertoli cells of adult albino rats exposed to polychlorinated biphenyls. Interdisciplinary Toxicology, 6(2), 83-92.

Liguori, I., Russo, G., Curcio, F., Bulli, G., Aran, L., Della-Morte, D., Gargiulo, G., Testa, G., Cacciatore, F., Bonaduce, D., & Abete, P. (2018). Oxidative stress, aging, and diseases. In Clinical Interventions in Aging (Vol. 13, pp. 757–772). Dove Medical Press Ltd. https://doi.org/10.2147/CIA.S158513

Manan, A. A., Tamin, N. S. I., Abdullah, N. H., & Wahab, M. (2015). The Malaysian National Cancer Registry Report (MNCR) 2007-2011 – From the Desk of the Director-General of Health Malaysia (pp. 2007–2011).

Nagao, M., Honda, M., Seino, Y., Yahagi, T., & Sugimura, T. (1977). Mutagenicities of smoke condensates and the charred surface of fish and meat. Cancer Letters, 2(4–5), 221–226. https://doi.org/10.1016/S0304-3835(77)80025-6

Nijveldt, R. J., Van Nood, E. L. S., Van Hoorn, D. E., Boelens, P. G., Van Norren, K., & Van Leeuwen, P. A. (2001). Flavonoids: a review of probable mechanisms of action and potential applications. The American journal of clinical nutrition, 74(4), 418-425.

OSU. (2001). Selenium | Linus Pauling Institute | Oregon State University. In Linus Pauling Institute (p. Magnesium).

Pham-Huy, L. A., He, H., & Pham-Huy, C. (2008). Free radicals, antioxidants in disease and health. In International Journal of Biomedical Science (pp. 89–96).

Packer, J. E., Mahood, J. S., Mora-Arellano, V. O., Slater, T. F., Willson, R. L., & Wolfenden, B. S. (1981). Free radicals and singlet oxygen scavengers: reaction of a peroxy-radical with β-carotene, diphenyl furan and 1, 4-diazobicyclo (2, 2, 2)-octane. Biochemical and biophysical research communications, 98(4), 901-906.

Piya, M. K., McTernan, P. G., & Kumar, S. (2013). Adipokine inflammation and insulin resistance: The role of glucose, lipids and endotoxin. In Journal of Endocrinology (Vol. 216, Issue 1, pp. T1–T15). https://doi.org/10.1530/JOE-12-0498

Ricordi, C., Garcia-Contreras, M., & Farnetti, S. (2015). Diet and inflammation: possible effects on immunity, chronic diseases, and life span. Journal of the American College of Nutrition, 34(sup1), 10-13.

Rizzo, A. M., Berselli, P., Zava, S., Montorfano, G., Negroni, M., Corsetto, P., & Berra, B. (2010). Endogenous antioxidants and radical scavengers. Advances in Experimental Medicine and Biology, 698, 52–67. https://doi.org/10.1007/978-1-4419-7347-4_5

Saha, S. K., Lee, S. Bin, Won, J., Choi, H. Y., Kim, K., Yang, G. M., Dayem, A. A., & Cho, S. G. (2017). Correlation between oxidative stress, nutrition, and cancer initiation. In International Journal of Molecular Sciences (Vol. 18, Issue 7, p. 1544). MDPI AG. https://doi.org/10.3390/ijms18071544

Salim, S. (2014). Oxidative stress and psychological disorders. Current neuropharmacology, 12(2), 140-147.

Samet, J. M., & Wages, P. A. (2018). Oxidative stress from environmental exposures. In Current Opinion in Toxicology (Vol. 7, pp. 60–66). Elsevier B.V. https://doi.org/10.1016/j.cotox.2017.10.008

Schiavone, S., Jaquet, V., Trabace, L., & Krause, K. H. (2013). Severe life stress and oxidative stress in the brain: From animal models to human pathology. Antioxidants and Redox Signaling, 18(12), 1475–1490. https://doi.org/10.1089/ars.2012.4720

Tan, B. L., Norhaizan, M. E., Liew, W. P. P., & Rahman, H. S. (2018). Antioxidant and oxidative stress: A mutual interplay in age-related diseases. In Frontiers in Pharmacology (Vol. 9, Issue OCT, p. 1162). Frontiers Media S.A. https://doi.org/10.3389/fphar.2018.01162

Traber, M. G., & Stevens, J. F. (2011). Vitamins C and E: beneficial effects from a mechanistic perspective. Free radical biology and medicine, 51(5), 1000-1013.

Wang, L., Muxin, G., Nishida, H., Shirakawa, C., Sato, S., & Konishi, T. (2007). Psychological stress-induced oxidative stress as a model of sub-healthy condition and the effect of TCM. Evidence-Based Complementary and Alternative Medicine, 4(2), 195–202. https://doi.org/10.1093/ecam/nel080

Wang, Y., Chun, O. K., & Song, W. O. (2013). Plasma and dietary antioxidant status as cardiovascular disease risk factors: A review of human studies. In Nutrients (Vol. 5, Issue 8, pp. 2969–3004). MDPI AG. https://doi.org/10.3390/nu5082969

Wellen, K. E., & Thompson, C. B. (2010). Cellular Metabolic Stress: Considering How Cells Respond to Nutrient Excess. In Molecular Cell (pp. 323–332). https://doi.org/10.1016/j.molcel.2010.10.004

Young, I. S., & Woodside, J. V. (2001). Antioxidants in health and disease. In Journal of Clinical Pathology (pp. 176–186). https://doi.org/10.1136/jcp.54.3.176