Angiogenesis, Inflammation & Therapeutics | Impact 0.1 (CiteScore) | Online ISSN  2207-872X
RESEARCH ARTICLE   (Open Access)

Vitamin D In Modulating Liver And Kidney Functions Following Cadmium Exposure In Vivo

Ahmad Maher Ibrahim Al Sayeh 1, Walid Theib Mohammad 1*, Fernando Jesús Plaza del Pino 2

+ Author Affiliations

Journal of Angiotherapy 8(2) 1-7 https://doi.org/10.25163/angiotherapy.829453

Submitted: 25 December 2023  Revised: 25 February 2024  Published: 28 February 2024 

The research determined how vitamin D plays a vital part in relieving kidney and liver damage from cadmium, thus having important implications for treatment.

Abstract


Background: Cadmium is known to affect liver and kidney function due to its toxicity detrimentally. Vitamin D reportedly mitigates cadmium-induced damage in various organs, yet its specific role in liver and kidney protection requires validation. Method: 24 male rats received cadmium chloride (CD) and nutritional vitamin D via intramuscular administration for 6 weeks. Liver and kidney function were assessed through ALT, AST, ALP, CRE, UA levels, and total protein concentration. Result: Groups A and B exhibited significant elevation (P<0.001) in ALT, AST, ALP, CRE, and UA levels compared to controls for 4 weeks, indicating cadmium-induced impairment. However, these markers significantly decreased after 6 weeks of vitamin D3 treatment, signifying improved liver and kidney function. Both groups showed increased TP levels compared to controls. Conclusion: Vitamin D mitigates liver and kidney damage induced by cadmium in adult male rats. The study highlights the protective effects of vitamin D against cadmium toxicity, potentially preserving organ function under toxin-induced stress.

Keywords: Cadmium (Cd), Vitamin D, Renal function, Hepatic function, Toxicity, Liver, Kidney

References


Abnosi MH, G. S. (2017). Cadmium chloride treatment of rats significantly impairs membrane integrity of mesenchymal stem cells via electrolyte imbalance and lipid peroxidation, a possible explanation of Cd related osteoporosis. Iran J . Basic Med Sci; 20:28.

Ana Carolina de Bragança, D. C. (2016). Vitamin D Deficiency Aggravates the Renal Features of Moderate Chronic Kidney Disease in 5/6 Nephrectomized Rats.

Ana Carolina de Bragança, D. C. (2018). Vitamin D Deficiency Aggravates the Renal Features of Moderate ChronicKidney Disease in 5/6 Nephrectomized Rats. frontires of medicin.

ANSES. (2017.). Exposure to cadmium: proposals of toxicological values of reference by ingestion, health values reference in biological environments.

Baraa yaqoob Al-Rahoo, B. R. (2020). The Role of Vitamin D3 as an Antioxidant and Hepatic Treatment against the Toxic Effect of Cadmium Chloride in The Rats. Indian Journal of Forensic Medicine & Toxicology, , Vol. 15, No 2 .

Bernard, A. (2016). Confusion about cadmium risks: the unrecognized limitations of an extrapolated paradigm. Environ. Health Perspect. 124.

Branca, J., Pacini, A., Gulisano, M., Taddei, N., Fiorillo, C., & Becatti, M. (2020). Cadmium-Induced Cytotoxicity: Effects on Mitochondrial Electron Transport Chain. .

Dongmei Yu, L. Z. (2019). Association of liver and kidney functions with Klotho gene methylation in a populatio. International Journal of Environmental Health Research,, https://DOI:10.1080/09603123.2019.1572106.

Federica Saponaro, A. S. (2016). An Update on Vitamin D Metabolism . Department of Surgical, Medical and Molecular Pathology and Critical Area, University of Pisa.

Gasmi, A., Peana, M., Arshad, M., Butnariu, M., Menzel, A., & Bjørklund, G. (2021). inhibitors and their roles in the modulation of carcinogenesis. . Krebs cycle: Activators.

GGkce Atikeler, M. Z. (2016). Effect of vitamin D on free radical metabolism in renal tissues of septic rats. Turkish Journal of Biochemistry.

Giuseppe Genchi, M. S. (2020). Review: The Effects of Cadmium Toxicity. . Public Health, 17, 3782;, https://doi:10.3390/ijerph17113782.

Gkçe Atikeler, M. Z. (2016). Effect of vitamin D on free radical metabolism in renal tissues of septic rats. Turkish Journal of Biochemistry – Türk Biyokimya Dergisi ; 41 (5): 316–321.

Heather R. Schaefer, B. M.-D. (2022). A systematic review of adverse health effects associated with oral cadmium exposure. US Food and Drug Administration, Center for Food.

Heather R. Schaefer, B. M.-D. (2022). A systematic review of adverse health effects associated with oral cadmium exposure . Elsevier , Regulatory Toxicology and Pharma.

Hokuto Nakata a, 1. S. (2021). Clinical biochemical parameters associated with the exposure to multiple environmental metals in residents from Kabwe, Zambia. elsevier.

Hokuto Nakata, S. M. (2021). CClinical biochemical parameters associated with the exposure to multiple environmental metals in residents from Kabwe, Zambia.. Chemosphere.262(127788)., https://doi.org/10.1016/j.chemosphere.2020.127788.

Hui Zou, J. S. (2017). Effects of Cadmium and/or Lead on Autophagy and Liver Injury in Rats . J .Biological Trace Element Research, https://doi.org/10.1007/s12011-020-02045-7.

Hui Zou1, 2. &. (2019 ). Effects of Cadmium and/or Lead on Autophagy and Liver Injury in Rats.

Iwona Markiewicz-Górka 1, *. ,. (2019). Alleviating EFFEect of _-Lipoic Acid and Magnesium on Cadmium-Induced Inflammatory Processes, Oxidative Stress and Bone Metabolism Disorders in Wistar Rats . journal of environmental research and public health.

Massimiliano Peana, A. P. (2022.). Biological Effects of Human Exposure to Environmental Cadmium . . Biomolecules, https://DOI:10.33.

Megahed, A., Gadalla, H., Abdelhamid, F., Almehmadi, S., Khan, A., Albukhari, T., & Risha, E. .. (2023). Vitamin D Ameliorates the Hepatic Oxidative Damage and Fibrotic Effect Caused by Thioacetamide in Rats. Biomedicines.

Megahed, A., Gadalla, H., Abdelhamid, F., Almehmadi, S., Khan, A., Albukhari, T., & Risha, E. (2023). Vitamin D Ameliorates the Hepatic Oxidative Damage and Fibrotic Effect Caused by Thioacetamide in Rats. . Biomedicines , 424, https://doi.org/10.3390/biome.

Michele Santiago dos Santos, D. C. (2021). The Restoration of Vitamin D Levels Slows the Progression of Renal Ischemic Injury in Rats Previously Deficient in Vitamin D. frontiers of medicin.

Mingkun Zhu, W. Z. (2019). Dietary Cadmium Chloride Supplementation Impairs Renal Function and Bone Metabolism of Laying Hens. J Animals, 998. , https://doi:10.3390/ani9110998.

Mohamed El-Boshy1, 2. |. (2019). Vitamin D3 and calcium cosupplementation alleviates cadmium hepatotoxicity in rat. wileyo.

Peana, M., Pelucelli, A., Chasapis, C., Perlepes, S., Bekiari, V., Medici, S., & Zoroddu, M. .. (2023). Biological Effects of Human Exposure to Environmental Cadmium. Biomolecules .

Schaefer, H. D. (2020). Cadmium: mitigation strategies to reduce dietary exposure. J.Food Sci. 85.

Tianfeng Zhanga, X. G. (2019). The effects of long-term exposure to low doses of cadmium on the health of the next generation of mice . Chemico-Biological Interactions 312 .

Van Horn, J. K. (2013). Reveow:Cadmium Physical and Chemical Properties. J. Encyclopedia of Metalloproteins.

Yimthiang, S., Pouyfung, P., Khamphaya, T., Kuraeiad, S., Wongrith, P., Vesey, D., . . . Satarug, S. (2022). Effects of Environmental exposur to CD and lead on risk of the diabetes and kidney dysfunction. envirion res public health.

Yimthiang, S., Pouyfung, P., Khamphaya, T., Kuraeiad, S., Wongrith, P., Vesey, D., . . . Satarug, S. (2022). Effects of Environmental Exposure to Cadmium and Lead on the Risks of Diabetes and Kidney Dysfunction. . Int. J. Environ. Res. Public Health.

Zongping, L. H. (2020). Effects of Cadmium and/or Lead on Autophagy and Liver Injury in Rats. Biological Trace Element Research ., https://doi.org/10.1007/s12011-020-02045-7.

Zoroddu, M., Aaseth, J., Crisponi, G., Medici, S., Peana, M., & Nurchi, V. .. (2019). The essential metals for humans: A brief overview.

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