Vitamin D In Modulating Liver And Kidney Functions Following Cadmium Exposure In Vivo

Ahmad Maher Ibrahim Al Sayeh ¹, Walid Theib Mohammad ^1*, Fernando Jesús Plaza del Pino ²

The research determined how vitamin D plays a vital part in relieving kidney and liver damage from cadmium, thus having important implications for treatment.

Abstract

Background: Cadmium is known to affect liver and kidney function due to its toxicity detrimentally. Vitamin D reportedly mitigates cadmium-induced damage in various organs, yet its specific role in liver and kidney protection requires validation. Method: 24 male rats received cadmium chloride (CD) and nutritional vitamin D via intramuscular administration for 6 weeks. Liver and kidney function were assessed through ALT, AST, ALP, CRE, UA levels, and total protein concentration. Result: Groups A and B exhibited significant elevation (P<0.001) in ALT, AST, ALP, CRE, and UA levels compared to controls for 4 weeks, indicating cadmium-induced impairment. However, these markers significantly decreased after 6 weeks of vitamin D3 treatment, signifying improved liver and kidney function. Both groups showed increased TP levels compared to controls. Conclusion: Vitamin D mitigates liver and kidney damage induced by cadmium in adult male rats. The study highlights the protective effects of vitamin D against cadmium toxicity, potentially preserving organ function under toxin-induced stress.

Keywords: Cadmium (Cd), Vitamin D, Renal function, Hepatic function, Toxicity, Liver, Kidney

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