Angiogenesis, Inflammation & Therapeutics | Impact 0.1 (CiteScore) | Online ISSN  2207-872X
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Interplay And Causative Relationship Between Frailty And Atherosclerosis

Anastasia V. Poznyak 1*, Victoria A. Khotina 2, Roghayyeh Vakili-Ghartavol 2,3, Victor Y Glanz 2, Vasily N. Sukhorukov 2, Alexander N. Orekhov 2*

+ Author Affiliations

Journal of Angiotherapy 8(2) 1-11 https://doi.org/10.25163/angiotherapy.829449

Submitted: 01 January 2024  Revised: 20 February 2024  Published: 27 February 2024 

Frailty syndrome (FS) and cardiovascular diseases have a significant interaction, which impacts both the patient experience and how they are managed. Knowledge about the intricate associations between the two could provide a meaningful way towards developing targeted interventions.

Abstract


Frailty syndrome is a complex condition with numerous contributing factors. It is characterized by a decline in physiological reserves and increased susceptibility to stress due to multi-system impairments. Commonly associated with aging, frailty can lead to adverse outcomes such as hospitalization, falls, and mortality. Cardiovascular diseases are recognized as a significant risk factor for frailty syndrome and frequently coexist in the elderly population. This review aims to explore the relationship between cardiovascular diseases and frailty syndrome. Research demonstrates that both acute and chronic cardiac conditions are prevalent among the risk factors for frailty. Cardiovascular diseases often manifest against the backdrop of atherosclerosis (AS) and are a leading cause of death in older adults. This review seeks to examine potential pathways through which cardiovascular events contribute to the development of frailty syndrome. Frail individuals often experience impaired physical function, significantly impacting their quality of life. Understanding the link between subclinical cardiovascular events and the pathogenesis of frailty syndrome is crucial for developing effective therapeutic interventions. Investigating how cardiovascular events influence the progression of frailty can provide valuable insights into improving clinical outcomes for frail patients.

Keywords: Frailty, Atherosclerosis, Cardiovascular disease

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