Advancements of Polymer-Based Transdermal Drug Delivery Systems in Drug Bioavailability and Patient Compliance in United States

Hunny Dabas ¹, Deepika Singh ¹, Faraat Ali ², Dipanjan Koley ¹, Mohammed. Aslam ³, Esra Tariq Anwer Bayrakdar ³, Manvi Singh 1*

This review comprehensively discusses the transdermal drug delivery systems (TDDS) in the area of drug administration, for non-invasive, precise, and efficient delivery, overcoming oral limitations.

Abstract

Transdermal drug delivery system (TDDS) helps in overcoming drug molecule barriers such as particle size, lipophilicity, permeability, and transports the medication directly to the blood circulation by employing physical and chemical penetration enhancers using polymers. The use of skin as a drug delivery route is challenging due to the stratum corneum's barrier properties that restrict the therapeutic bioavailability of the medications. Both, natural and synthetic  polymers are used in TDDS to transport the medication into circulation via diffusion, and swelling control. TDDS is generally achieved by using transdermal patches containing one or more pharmaceutical active entities that are placed on unbroken skin for delivering active entities directly to the bloodstream by crossing the skin barrier. TDDS is the trendiest -delivery system as it is painless, non-invasive, self-administrative, avoids hepatic first-pass metabolism, and delivers poorly soluble drugs and increases the bioavailability. An overview of TDDS is provided in this review article, including its advantages over traditional dosage forms, limitations, different components of transdermal patches, modern techniques as well as transdermal products available in US market.

Keywords: Transdermal, Permeability, Transdermal patch, US Market, Polymer-based drug delivery

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