Stromal Interaction Molecule-1 (STIM1): Orchestrating Calcium Signaling in Cancer and Hematologic Malignancies

Rabiatul Basria S. M. N. Mydin¹, Adam Azlan¹, Eman Salem Saeed Algariri,¹ Nur Azuar Abdul Rahim^2,3, Emmanuel Jairaj Moses¹, Narazah Mohd Yusoff¹

Abstract

STIM-1 plays pivotal roles in carcinogenesis via calcium signalling. STIM-1 regulatory functions in malignancies were observed to be significantly implicated resulting in various oncogenic properties. STIM-1 induced oncogenic properties mainly via the store operated calcium entry (SOCE) disruption. Moreover, calcium signalling mediated via STIM-1 could also in synergy with reactive oxygen species (ROS) mediates oncogenic characteristics. This would often lead to induction of pro-survival mechanism in cancer. Understanding STIM-1 lanscape is therefore crucial in contributing to the knowledge on cancer alleviation. This review emphasized on the significance of STIM1 in various cancers including hematologic malignancies and its intricate influence over ROS and various cellular processes.

Keywords: Cancer, Disease, Stromal Interaction Molecule 1 (STIM1), Store-Operated Calcium Entry (SOCE), Calcium Signalling, Hematological Malignancies

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