Modes of Anti-angiogenesis in Chemical Perspectives

Shan Arif ^{a, b}, Muhammad Imran ^{a, b}, Muhammad Adnan Iqbal ^{a, b}

In the current study, role of synthesized chemical pharmacores like Humulus lupulus, Hypericum perforatum, Panax ginseng, Coptis chinensis and Rheum palmatum (Varinska et al., 2010) as anti-angiogenesis has been compiled. 

Abstract

Angiogenesis is a process which involves formation of new blood vessels and it involves the growth, migration and differentiation of endothelial cells that cause line inside the walls of blood vessels. This process is controlled by chemical signals in body and these signals such as vascular endothelial growth factor (VEGF), combine with receptors on the surface of normal endothelial cells and increase the growth and survival of new blood vessels. Some drugs are used to diminish the combining of VEGF with the receptors from sending the growth signals in new blood vessels. This process is called anti-angiogenesis and also called cancer growth blockers. In the current study, role of synthesized chemical pharmacores like Humulus lupulus, Hypericum perforatum, Panax ginseng, Coptis chinensis and Rheum palmatum (Varinska et al., 2010) as anti-angiogenesis has been compiled. The structure activity relationship in inhibiting the angiogenesis has also been discussed.

Key words: Anti-angiogenesis, Genistein, Epigallocatechin Gallate/ EGCG, Angiostatin.

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