EMAN RESEARCH PUBLISHING | Journal | <p>A critical disease approach of angiogenesis in obese patients</p>
Cancer Angiogenesis biology and therapeutics, SCOPUS CiteScore 0.9/Impact factor 1.0 (unofficial)

A critical disease approach of angiogenesis in obese patients

Suzana Binte Hashim

+ Author Affiliations

Journal of Angiotherapy 1(1) 041-043 https://doi.org/10.25163/angiotherapy.11001021108100517

Submitted: 11 September 2016  Revised: 16 February 2017  Published: 10 May 2017 

obesity has a strong association with several metabolic disorders such as the type 2 diabetes and cardiovascular disease, which affect over 50% of an adult population


Obesity is a medical issue that is affecting an ever greater population worldwide. Also, obesity has a strong association with several metabolic disorders such as the type 2 diabetes and cardiovascular disease, which affect over 50% of an adult population (Wellen, Hotamisligil et al. 2003). Previous studies have shown that obesity facilitates the development of chronic diseases such as inflammation-based pathologies, stroke, osteoarthritis, cancer, hypertension, sleep apnoea, and arthritis (Hotamisligil 2003, Parul Singla 2010, Marta González-Castejón 2011). Importantly, the amount of cases of clinical obesity is constantly increasing, and in 2014 more than half a billion people are considered obese (WHO 2015). Therefore, it is paramount to find a solution for this problem and currently, one of the interesting avenues to combat obesity has been through angiogenesis.

Keywords: Obesity, Angiogenesis, Patients


Adair, T. and J. Montani (2010). Angiogenesis. Chapter 1: Overview of Angiogenesis. San Rafael (CA), Morgan & Claypool Life Sciences.

Alexander J. German a, V. H. R., Allison C. German, I. Stuart Wood, Paul Trayhurn (2010). "Obesity, its associated disorders and the role of inflammatory adipokines in companion animals." The Veterinary Journal,  185, 4-9.

Bråkenhielm, E., R. Cao, B. Gao, B. Angelin, B. Cannon, P. Parini and Y. Cao (2004). "Angiogenesis Inhibitor, TNP-470, Prevents Diet-Induced and Genetic Obesity in Mice." Circulation Research, 94(12), 1579-1588.

Cao, Y. (2007). "Angiogenesis modulates adipogenesis and obesity." The Journal of Clinical Investigation, 117(9), 2362-2368.

Chantre, P. and D. Lairon (2002). "Recent findings of green tea extract AR25 (Exolise) and its activity for the treatment of obesity." Phytomedicine, 9(1), 3-8.

Christiaens, V. and H. R. Lijnen (2010). "Angiogenesis and development of adipose tissue." Mol Cell Endocrinol, 318(1-2), 2-9.

Cutchins, A., D. B. Harmon, J. L. Kirby, A. C. Doran, S. N. Oldham, M. Skaflen, A. L. Klibanov, N. Meller, S. R. Keller, J. Garmey and C. A. McNamara (2012). "Inhibitor of differentiation-3 mediates high fat diet-induced visceral fat expansion." Arterioscler Thromb Vasc Biol, 32(2), 317-324.

Daquinag, A. C., Y. Zhang and M. G. Kolonin (2011). "Vascular targeting of adipose tissue as an anti-obesity approach." Trends Pharmacol Sci, 32(5), 300-307.

Du, H., J.-S. You, X. Zhao, J.-Y. Park, S.-H. Kim and K.-J. Chang (2010). "Antiobesity and hypolipidemic effects of lotus leaf hot water extract with taurine supplementation in rats fed a high fat diet." Journal of Biomedical Science, 17(Suppl 1), S42.

Hausman, G. J. and R. L. Richardson (2004). "Adipose tissue angiogenesis." J Anim Sci, 82(3), 925-934.

Hotamisligil, K. E. W. a. G. S. (2003). "Obesity-induced inflammatory changes in adipose tissue." J. Clin. Invest.(112), 4.

Kim, J. D. (2010). Anti-angiogenic agents and anti-obesity substances applied with anti-angiogenesis from natural products, Google Patents.

Kim, Y. S., Y. M. Lee, H. Kim, J. Kim, D. S. Jang, J. H. Kim and J. S. Kim (2010). "Anti-obesity effect of Morus bombycis root extract: Anti-lipase activity and lipolytic effect." Journal of Ethnopharmacology, 130(3), 621-624.

Lijnen, H. R. (2008). "Angiogenesis and obesity." Cardiovascular Research, 78(2), 286-293.

Lin, J., M. A. Della-Fera and C. A. Baile (2005). "Green Tea Polyphenol Epigallocatechin Gallate Inhibits Adipogenesis and Induces Apoptosis in 3T3-L1 Adipocytes." Obesity Research, 13(6), 982-990.

Marta González-Castejón, A. R.-C. (2011). "Dietary phytochemicals and their potential effects on obesity: A review." Pharmacological Research, 64, 438– 455.

Mojzis, J., L. Varinska, G. Mojzisova, I. Kostova and L. Mirossay (2008). "Anti-angiogenic effects of flavonoids and chalcones." Pharmacological Research 57(4), 259-265.

Nishimura, S., I. Manabe, M. Nagasaki, Y. Hosoya, H. Yamashita, H. Fujita, M. Ohsugi, K. Tobe, T. Kadowaki, R. Nagai and S. Sugiura (2007). "Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels." Diabetes, 56(6), 1517-1526.

Ono, Y., E. Hattori, Y. Fukaya, S. Imai and Y. Ohizumi (2006). "Anti-obesity effect of Nelumbo nucifera leaves extract in mice and rats." Journal of Ethnopharmacology, 106(2), 238-244.

Parul Singla, A. B., Anuj A Parkash (2010). "Metabolic effects of obesity: A review." World J Diabetes, 1(3), 76-88.

Rupnick, M. A., D. Panigrahy, C. Y. Zhang, S. M. Dallabrida, B. B. Lowell, R. Langer and M. J. Folkman (2002). "Adipose tissue mass can be regulated through the vasculature." Proc Natl Acad Sci U S A, 99(16), 10730-10735.

Voros, G., E. Maquoi, D. Demeulemeester, N. Clerx, D. Collen and H. R. Lijnen (2005). "Modulation of Angiogenesis during Adipose Tissue Development in Murine Models of Obesity." Endocrinology, 146(10), 4545-4554.

Wellen, K. E., G. Hotamisligil, xF and S. khan (2003). "Obesity-induced inflammatory changes in adipose tissue." The Journal of Clinical Investigation, 112(12), 1785-1788.

WHO. (2015). Obesity and overweight.

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