EMAN RESEARCH PUBLISHING | Journal | <p>The use of sophorolipids as anti-angiogenic therapy for cancer treatment</p>
Inflammation Cancer Angiogenesis Biology and Therapeutics | Impact 0.1 (CiteScore) | Online ISSN  2207-872X
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The use of sophorolipids as anti-angiogenic therapy for cancer treatment

Shazmin Kithur Mohamed

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Journal of Angiotherapy 1(1) 027-029 https://doi.org/10.25163/angiotherapy.11000521108100517

Submitted: 11 September 2016  Revised: 22 February 2017  Published: 10 May 2017 

Sophorolipids are of growing commercial interest because they can be easily produced in extreme1y high yields from cheap raw materials, such as vegetable oils, n-alkanes and industrial waste products.


Sophorolipids are of growing commercial interest because they can be easily produced in extreme1y high yields from cheap raw materials, such as vegetable oils, n-alkanes and industrial waste products. Sophorolipids have been reported to possess bacteriostatic properties, hence they are used in cosmetics and deodorants. They are also used in the manufacturing of detergents (Furstner A et.al.,2000). Studies have shown that Sophorolipids that have a single double bond in their fatty acid chain have anticancer activity (Dey G et. al., 2014). Recently, Chen et al. have demonstrated that sophorolipids had an effect against hepatocellular carcinoma. In those studies, sophorolipids were found to induce apoptosis when cultured with human liver cancer cells (H7402). Sophorolipids exist in a natural mixture, and, although there have been reports of their effects against malignancy, this is the first study to examine sophorolipids against any cancer cell line. These anticancer responses were dose- and derivative-dependent and likely kill cancer cells by necrosis.

Keywords: Sophorolipids, Cancer, Angiogenesis


Chen J, Song X, Zhang H, Qu YB and Miao JY (2006). Sophorolipid produced from the new yeast strain Wickerhamiella domercqiae induces apoptosis in H7402 human liver cancer cells. Appl Microbiol Biotechnol 72(1):52-59.

Cooper DG, Zajic JE and Gerson DF (1979). Production of surface active lipids by Corynebacterium lepus. Appl. Environ. Microbial., 37: 4-10.

Dey G, Bharti R, Sen R and Mandal M (2014). Microbial amphiphiles: a class of promising new-generation anticancer agents. Drug Discovery Today, DRUDIS 1492:1-11.

Fiechter A (1992a). Biosurfactants: Moving towards industrial applications. Trends in Biotechnol., 10:208-216.

Fiechter A (1992b). Integrated systems for biosurfactant synthesis. Pure Appl. Chem., 63(11): 1739-1743.

Furstner, A., K. Radkowski, J. Grabowski, C. Wirtz, and R. Mynott (2000). Ring-closing  alkyne metathesis: Application to the total synthesis of sophorolipid lactone. Journal of Organic Chemistry, 65:8758-8762.

Georgiou G, Lin SC and Sharma MM (1992). Surface active compounds from microorganisms. Biotechnol., 10:60-65.

Guilmanov V, Ballistreri A, Impallomeni G, and Gross RA (2002). Oxygen transfer rate and

sophorose lipid production by Candida bombicola. Biotechnology and Bioengineering, 77:489-494.

Harris AL (1997). Antiangiogenesis for cancer therapy. Lancet 349 Suppl 2:SII13-15.

Harvey S, Elashvili I, Valdes JJ, Kammley D and Chakrabarty AM (1990). Enhanced removal of Exxon Valdez spilled oil from Alaskan gravel by a microbial surfactant.  Biotechnol. 8:228-230.

Inge NA, Bogaert V, Saerens K, Muynck CD, Develter D, Soetaert W and Vandamme EJ (2007). Microbial production and application of sophorolipids. Appl Microbiol Biotechnol, 76:23–34.

Shah V, Doncel GF, Seyoum T, Eaton KM, Zalenskaya I, Hagver R, Azim A, and Gross R (2005). Sophorolipids: novel glycolipid preventive agents for conception and sexual transmission. Antimicrob. Agents Chemother. 49:4093-4100.

Shin JD, Lee J , Kim YB, Han I and Kim E (2010). Production and characterization of methyl ester sophorolipids with 22-carbon-fatty acids. Bioresource Technology, 101:3170 3174.

Wadekar SD, Kale SB; Lali AM, Bhowmick DN & Pratap AP (2012b). Utilization of sweetwater as a cost-effective carbon source for sophorolipids production by Starmerella bombicola (ATCC 22214). Preparative Biochemistry and Biotechnology, 42:125-42.

Vedaraman N and Venkatesh NM (2010). The effect of medium composition on the production of sophorolipids and the tensiometric properties by Starmerella bombicola MTCC 1910. Polish Journal of Chemical Technology, 12(2):9 -13.

West CD and Harwell JH (1992). Surfactants and subsurface remediation. Environ. Sci. Technol, 26(12):2324-2330.

Zajic JE and Seffens W(1984). Biosurfactants.  CRC Crit. Rev. Biotechnol., 1(2):87-109.

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