CNS Vasculitis in A Patient with Systemic Lupus Erythematosus: A Case Report

Ramesh T V¹, Gopi Ayyaswamy², Zioni Sangeetha³, Vinod Kumar P^*4

Active treatment of SLE is required to prevent the progression of systemic involvement.

Abstract

Systemic Lupus Erythematosus (SLE) is a chronic idiopathic autoimmune disease with multi-system involvement. Clinical manifestations range from mild constitutional symptoms to life-threatening systemic manifestations. Neurological involvement in SLE occurs in 10 to 80 percent of patients and has a broad spectrum of symptoms, including chronic headache, impaired cognitive function, seizures, delirium, psychosis, vasculitis, and thromboembolic events. The pathophysiology by which SLE affects the nervous system includes vasculopathy, auto-antibodies, secondary factors (infections, metabolic dysfunction, and drug-induced), and other miscellaneous factors like inflammatory mediators (cytokines, chemokines, neuropeptides, nitric oxide etc.).

Keywords: SLE, vasculopathy, auto-antibodies, secondary factors.

References

C. M. Everett, T. D. Graves, S. Lad, H. R. Jäger, M. Thom, D. A. Isenberg, M. G. Hanna, (2008). Aggressive CNS lupus vasculitis in the absence of systemic disease activity, Rheumatology, Volume 47, Issue 1, January 2008, Pages 107-109.

https://doi.org/10.1093/rheumatology/kem264

Rowshani AT, Remans P, Rozemuller A, et al. (2005). Cerebral vasculitis as a primary manifestation of systemic lupus erythematosus. Annals of the Rheumatic Diseases 2005; 64:784-786.

https://doi.org/10.1136/ard.2004.026542

Kakati S, Barman B, Ahmed SU, Hussain M. (2017). Neurological Manifestations in Systemic Lupus Erythematosus: A Single Centre Study from North East India. J Clin Diagn Res. 2017;11(1): OC05-OC09. doi:10.7860/JCDR/2017/23773.9280

https://doi.org/10.7860/JCDR/2017/23773.9280