Neutrophil to Lymphocyte Ratio and Clinical Outcomes in COPD

Lionel John J, Srinivasan N, Shiva P, Radhakrishnan P

NLR is a valuable predictor of AECOPD and mortality. Furthermore, it correlates well, and in some studies is even more accurate, than other traditional inflammatory indexes (WBC counts alone) or more complex and expensive markers (CRP and calprotectin).

Abstract

Chronic obstructive pulmonary disease (COPD) is a disabling condition that is characterised by poorly reversible airflow limitation and inflammation. Acute exacerbations of COPD are a common cause of hospitalisation and death among COPD patients. Several biochemical markers have been studied as outcome predictors in COPD; however, their measurement often requires significant time and resources. Relatively simple biomarkers of inflammation calculated from routine complete blood count tests, such as the neutrophil to lymphocyte ratio (NLR), might also predict COPD progression and outcomes. This review discusses the available evidence from studies investigating the associations between the NLR, COPD exacerbations and death in this patient group.

Keywords: COPD, NLR.

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