Journal of Primeasia
Integrative Disciplinary Research | Online ISSN 3064-9870
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RESEARCH ARTICLE   (Open Access)
Contents Vol 6 (1)

Association Between Hepatocellular Carcinoma and Diabetes Mellitus

Md Samiul Bashir1*, Moazzam Hossian2, Md. Khaja Mohi Uddin3, Md, Abu Sayem4, Afrin Sultana5, Faisal Akter Rana6, Tanzila Akter7, Nishita Das8, Md Sohel Rana9, Shib Shankar Das10

+ Author Affiliations

Journal of Primeasia 6 (1) 1-7 https://doi.org/10.25163/primeasia.6110193

Submitted: 02 January 2025 Revised: 07 March 2025  Published: 15 March 2025 

Abstract

Background: Diabetes Mellitus (T2DM) Type 2, presents a risk factor for the development of several chronic diseases, including Diabetes Mellitus Hepatocellular Carcinoma and Diabetes (HCC). Diabetes associated hyperglycemia is gaining importance due to the high prevalence of nonalcoholic fatty liver disease (NAFLD) which is a primary cause of liver fibrosis, cirrhosis, and HCC. This study is designed to evaluate the effect of T2DM on the progression of HCC along with its related metabolic markers in a Bangladeshi population. Methods: A laboratory based cross-sectional study was done at the Institute of Health Technology Laboratory, Kurigram, Bangladesh between June 2023 to May 2024. A total of 105 histologically confirmed HCC patients were included in the study through purposive sampling. Fasting blood sugar (FBS), 2 Hour Post Prandial glucose test (2HP), glycosylated Hemoglobin (HbA1c) and Alpha Feto-protein (AFP) blood biochemistry analyses were done. Data were analyzed using SPSS 26.0 software. Statistical significance was set at 5% level. Results: Participants had a mean age of 50.2 (SD=12.5). In the cohort, the majority (52%) were diabetic, others comprised 30% Prediabetic and 18% normal glycemic levels. All diabetic groups demonstrated elevated AFP levels along with total liver cirrhosis, while males had elevated levels compared to females(p=0.038). Conclusion: Diabetes-induced metabolic disorders are connected with liver injury due to the positive correlation between AFP level glycemic markers. The connection between diabetes and hepatocellular carcinoma is reinforced by raised AFP in diabetic patients. More research needs to be done to lessen the risk of HCC related to diabetes.Keywords: Hepatocellular Carcinoma (HCC), Diabetes Mellitus (DM), Alpha-Fetoprotein (AFP), Metabolic Dysfunction, Liver Disease.

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