Inflammation Cancer Angiogenesis Biology and Therapeutics | Impact 0.1 (CiteScore) | Online ISSN  2207-872X
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Innovative Rehabilitation Strategies for Chemical Dependency: Integrating Biochemical Insights and Psychosocial Approaches

Mykhailo Zhylin 1*, Viktoriia Mendelo 2, Oleksii Tolmachov 3, Olesia Ryhel 4, Oksana Yudenko 5

+ Author Affiliations

Journal of Angiotherapy 8(7) 1-10 https://doi.org/10.25163/angiotherapy.879818

Submitted: 23 May 2024  Revised: 26 July 2024  Published: 27 July 2024 

Abstract

Background: The increasing prevalence of substance use disorders underscores the need for a deeper understanding of the biochemical mechanisms underlying addiction, especially their impact on blood and genetic health. Chemical dependency not only affects physiological processes but also interacts with genetic predispositions, influencing the course and complications of addiction. Methods: This study investigates the relationship between chemical dependency, biochemical factors, and their implications for blood composition and genetic health. We examined how substance use disorders alter hematological profiles, affect hematopoiesis, and interact with genetic factors. The research involved analyzing changes in blood markers and genetic expressions related to addiction and recovery. Progressive rehabilitation techniques were evaluated for their effectiveness in addressing these issues. Results: Our findings reveal that chemical dependency significantly impacts blood composition, including alterations in hematological markers and disturbances in hematopoietic processes. Genetic factors were found to play a role in exacerbating addiction risks and health complications. Progressive rehabilitation techniques incorporating advancements in genetics and biochemistry were shown to improve outcomes by providing personalized interventions that address both physiological and psychological aspects of recovery. Conclusion: The study highlights the importance of integrating biochemical and genetic assessments into rehabilitation programs to enhance the effectiveness of treatment. Personalized approaches that address the interplay between addiction, blood health, and genetic predispositions promote better psychosocial adaptation and biochemical stabilization. This comprehensive understanding contributes valuable insights into developing more effective rehabilitation practices, ultimately supporting improved mental health and overall well-being.

Keywords: Chemical Dependency, Biochemical Factors, Psychosocial Rehabilitation, Neurotransmitters, Personalized Interventions

References

Agarwal, B., Brooks, S. K., & Greenberg, N. (2020). The role of peer support in managing occupational stress: a qualitative study of the sustaining resilience at work intervention. Workplace Health & Safety, 68(2), 57-64.

Aghenitei, M., & Galateanu, O. E. (2023). Global Drug Addiction. EIRP Proceedings, 18(1), 473-488.

Alvarez-Monjaras, M., Mayes, L. C., Potenza, M. N., & Rutherford, H. J. (2019). A developmental model of addictions: integrating neurobiological and psychodynamic theories through the lens of attachment. Attachment & human development, 21(6), 616-637.

Amaro, H., Sanchez, M., Bautista, T., & Cox, R. (2021). Social vulnerabilities for substance use: Stressors, socially toxic environments, and discrimination and racism. Neuropharmacology, 188, 108518.

Andersson, G., & Cuijpers, P. (2009). Internet-based and other computerized psychological treatments for adult depression: a meta-analysis. Cognitive behaviour therapy, 38(4), 196-205.

Atzori, M., Cuevas-Olguin, R., Esquivel-Rendon, E., Garcia-Oscos, F., Salgado-Delgado, R. C., Saderi, N., ... & Salgado, H. (2016). Locus ceruleus norepinephrine release: a central regulator of CNS spatio-temporal activation? Frontiers in synaptic neuroscience, 8, 25.

Baumeister, R. F., & Leary, M. R. (2017). The need to belong: Desire for interpersonal attachments as a fundamental human motivation. Interpersonal development, 57-89.

Blum, K., Bowirrat, A., Elman, I., Baron, D., Thanos, P. K., Gold, M. S., Hanna, C., Makale, M.T., Sunder, K., Jafari, N., Zeine, F., Murphy, K.T., Makale, M., & Badgaiyan, R. D. (2023). Evidence for the DRD2 gene as a determinant of Reward Deficiency Syndrome (RDS). Clinical and experimental psychology, 9(4), 8.

Boisvert, D., Wells, J., Armstrong, T. A., & Lewis, R. H. (2018). Serotonin and self-control: A genetically moderated stress sensitization effect. Journal of Criminal Justice, 56, 98-106.

Bornstein, R. F. (2012). From dysfunction to adaptation: An interactionist model of dependency. Annual Review of Clinical Psychology, 8(1), 291-316.

Bowen, S. A. (2019). Spiritual Rebel: A Positively Addictive Guide to Finding Deeper Perspective and Higher Purpose. Monkfish Book Publishing.

Carreno, D. F., & Pérez-Escobar, J. A. (2023). Addiction in existential positive psychology (EPP, PP2. 0): from a critique of the brain disease model towards a meaning-centered approach. In A Second-Wave Positive Psychology in Counselling Psychology (pp. 145-165). Routledge.

Carroll, M. W. (2009). One size does not fit all: A framework for tailoring intellectual property rights. Ohio St. LJ, 70, 1361.

Cernasev, A., Hohmeier, K. C., Frederick, K., Jasmin, H., & Gatwood, J. (2021). A systematic literature review of patient perspectives of barriers and facilitators to access, adherence, stigma, and persistence to treatment for substance use disorder. Exploratory research in clinical and social pharmacy, 2, 100029.

Cervone, D., Caldwell, T. L., & Orom, H. (2008). Beyond Person and Situation Effects: Intra-Individual Personality Architecture and Its Implications for the Study of Personality and Social Behavior. Personality and social behavior, 9-48.

Chikkannaiah, M., & Reyes, I. (2021). New diagnostic and therapeutic modalities in neuromuscular disorders in children. Current problems in pediatric and adolescent health care, 51(7), 101033.

Danko, D. I. & Yudenko, O. V. (2022). Myofascial pain syndrome in military personnel of the Armed Forces of Ukraine: An urgent issue of physical therapy during martial law. In Biomedical Engineering and Technology. Materials from the II International Scientific and Practical Conference (pp. 114-117). Kyiv: National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”. ISSN (Online) 2707-8434. http://biomedconf.kpi.ua/biosafety/paper/viewFile/27069/15499

Danko, D. I., & Yudenko, O. V. (2024). Substantiation of the use of innovative physical therapy tools in the Armed Forces of Ukraine with myofascial pain syndrome due to long-term use of personal protective equipment. The Ukrainian Scientific Medical Youth Journal, 146(2), 136-144. https://doi.org/10.32345/USMYJ.2(146).2024.136-144

Deak, J. D., & Johnson, E. C. (2021). Genetics of substance use disorders: a review. Psychological medicine, 51(13), 2189-2200.

DiClemente, C. C. (2018). Addiction and change: How addictions develop and addicted people recover. Guilford Publications.

Dobbs, P. D., Hodges, E. J., Dunlap, C. M., & Cheney, M. K. (2020). Addiction vs. dependence: a mixed methods analysis of young adult JUUL users. Addictive Behaviors, 107, 106402.

Dreitzel, H. P. (2021). Human interaction and emotional awareness in gestalt therapy: Exploring the phenomenology of contacting and feeling. Routledge.

Earley, P. H., & Finver, T. (2013). Addiction to propofol: a study of 22 treatment cases. Journal of addiction medicine, 7(3), 169-176.

Evans, G. W., & Kim, P. (2010). Multiple risk exposure as a potential explanatory mechanism for the socioeconomic status–health gradient. Annals of the New York Academy of Sciences, 1186(1), 174-189.

Fenech, M. (2012). Folate (vitamin B9) and vitamin B12 and their function in the maintenance of nuclear and mitochondrial genome integrity. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 733(1-2), 21-33.

Förster, K., & Kanske, P. (2022). Upregulating positive affect through compassion: Psychological and physiological evidence. International Journal of Psychophysiology, 176, 100-107.

Freeman, T. E., Jordan, H. R., & Madson, M. B. (2020). Coping styles mediate the association between posttraumatic stress disorder symptoms and alcohol outcomes in college students. Substance Use & Misuse, 55(14), 2371-2378.

Fronk, G. E., Sant'Ana, S. J., Kaye, J. T., & Curtin, J. J. (2020). Stress allostasis in substance use disorders: promise, progress, and emerging priorities in clinical research. Annual review of clinical psychology, 16(1), 401-430.

Giovannelli, P., & Pfister, H. (2023). Neuro-circuitry of Impulsivity and its Relation to Substance Use Disorders. Archives of Clinical Psychiatry, 50(6).

Green, K. E., Blue, J. R., & Natal, S. N. (2021). An integrated model of nature and nurture factors that contribute to addiction and recovery. Substance use & misuse, 56(8), 1095-1107.

Green, R. (2017). Vitamin B12 deficiency from the perspective of a practicing hematologist. Blood, The Journal of the American Society of Hematology, 129(19), 2603-2611.

Greydanus, D. E., & Merrick, J. (2013). Substance use, addiction, and history. International Journal on Disability and Human Development, 12(3), 229-233.

Hasin, D. S., & Larson, F. R. (2021). Substance Use Disorder Diagnoses in DSM-5. The American Psychiatric Association Publishing Textbook of Substance Use Disorder Treatment, 47.

Hegewald, J. A. (2022). Dependency, Subjugation and Survival. Bonn: Bonn Center for Dependency and Slavery Studies, 2022. In: BCDSS Working Papers, 09. https://doi.org/10.48565/bonndoc-89

Henderson, E. C. (2009). Understanding addiction. Univ. Press of Mississippi.

Hood, L. E., Leyrer-Jackson, J. M., & Olive, M. F. (2020). Pharmacotherapeutic management of co-morbid alcohol and opioid use. Expert opinion on pharmacotherapy, 21(7), 823-839.

Hunt, A. (2014). Expanding the biopsychosocial model: The active reinforcement model of addiction. Graduate Student Journal of Psychology, 15, 57-69.

Hutsaliuk, O., Bondar, Iu., Kotsiurba, O., Ostapenko, O., Skoptsov, K., & Boiko, O. (2023). Factor-criteria assessment of greening prerequisites for transport infrastructure development in Ukraine. In IOP Conference Series: Earth and Environmental Science, 1126(1). 012009. DOI: 10.1088/1755-1315/1126/1/012009

Hutsaliuk, O., Bondar, Iu., Sereda, N., Babych, O., & Shchoholieva, I. (2021). Organization and management of the development of ecological tourism in a circular economy. In E3S Web Conferences (Vol. 255), 01026. https://doi.org/10.1051/e3sconf/202125501026

Imran, H. (2023). Effectiveness of CBT based relapse prevention therapy in reducing relapse risk and craving among individuals with substance use disorder. The Mind-Journal of Psychology, 2(1), 1-12.

Johnston, L. D., Miech, R. A., O'Malley, P. M., Bachman, J. G., Schulenberg, J. E., & Patrick, M. E. (2022). Monitoring the future national survey results on drug use, 1975-2021: Overview, key findings on adolescent drug use. Institute for Social Research The University of Michigan.

Kaplan, G., Xu, H., Abreu, K., & Feng, J. (2022). DNA epigenetics in addiction susceptibility. Frontiers in genetics, 13, 806685.

Kastberg, E., Buchko, A., & Buchko, K. (2020). Developing emotional intelligence: The role of higher education. Journal of Organizational Psychology, 20(3).

Kopak, A. M., & Hoffmann, N. G. (2024). Key criteria within DSM-5 substance use disorder diagnoses: evidence from a correctional sample. Journal of Offender Rehabilitation, 63(1), 37-57.

Lange, K. W. (2020). Omega-3 fatty acids and mental health. Global Health Journal, 4(1), 18-30.

Maremmani, I., Pacini, M., & Fountoulakis, K. N. (2019). Psychobiology of Addictions. Psychobiology of Behaviour, 171-192.

María-Ríos, C. E., & Morrow, J. D. (2020). Mechanisms of shared vulnerability to post-traumatic stress disorder and substance use disorders. Frontiers in Behavioral Neuroscience, 14, 6.

Matejevic, M., Jovanovic, D., & Lazarevic, V. (2014). Functionality of family relationships and parenting style in families of adolescents with substance abuse problems. Procedia-Social and Behavioral Sciences, 128, 281-287.

McHugh, R. K., Fitzmaurice, G. M., Votaw, V. R., Geyer, R. B., Ragnini, K., Greenfield, S. F., & Weiss, R. D. (2024). Cognitive behavioral therapy for anxiety and opioid use disorder: Development and pilot testing. Journal of Substance Use and Addiction Treatment, 160, 209296.

Menon, R., Murphy, P. G., & Lindley, A. M. (2011). Anaesthesia and pituitary disease. Continuing Education in Anaesthesia, Critical Care & Pain, 11(4), 133-137.

Moeller, S. J., Platt, J. M., Wu, M., & Goodwin, R. D. (2020). Perception of treatment need among adults with substance use disorders: longitudinal data from a representative sample of adults in the United States. Drug and alcohol dependence, 209, 107895.

Ngui, H. H. L., Kow, A. S. F., Lai, S., Tham, C. L., Ho, Y. C., & Lee, M. T. (2022). Alcohol withdrawal and the associated mood disorders—a review. International Journal of Molecular Sciences, 23(23), 14912.

O'Connor, R. M., & Kenny, P. J. (2022). Utility of ‘substance use disorder’as a heuristic for understanding overeating and obesity. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 118, 110580.

Orciari, E. A., Perman-Howe, P. R., & Foxcroft, D. R. (2022). Motivational Interviewing-based interventions for reducing substance misuse and increasing treatment engagement, retention, and completion in the homeless populations of high-income countries: an equity-focused systematic review and narrative synthesis. International Journal of Drug Policy, 100, 103524.

Otani, V. H. O., Novaes, R. A., Pedron, J., Nabhan, P. C., Rodrigues, T. M., Chiba, R., ... & Vissoci, J. R. N. (2024). Framework proposal for Role-Playing Games as mental health intervention: the Critical Skills methodology. Frontiers in Psychiatry, 15, 1297332.

Peixoto, L. S. A., & Gondim, S. M. G. (2020). Mindfulness and emotional regulation: a systematic literature review. SMAD. Revista eletrônica saúde mental álcool e drogas, 16(3), 88-104.

Popescu, A., Marian, M., Dragoi, A. M., & Costea, R. V. (2021). Understanding the genetics and neurobiological pathways behind addiction. Experimental and Therapeutic Medicine, 21(5), 1-10.

Rice, J. S. (2017). A disease of one's own: Psychotherapy, addiction and the emergence of co-dependency. Routledge.

Room, R. (2006). Taking account of cultural and societal influences on substance use diagnoses and criteria. Addiction, 101, 31-39.

Rosenberg, K. P. (Ed.). (2014). Behavioral addictions: Criteria, evidence, and treatment. Academic Press.

Rosenthal, R. J., & Faris, S. B. (2019). The etymology and early history of ‘addiction’. Addiction Research & Theory, 27(5), 437-449.

Semenets-Orlova, I., Halytska, N., Klochko, A., Skakalska, I., & Kosyuk, N. (2019a). Information Exchange and Communication Infrastructure in the Public Sector. In CMiGIN (pp. 519-529). Retrieved from https://ceur-ws.org/Vol-2588/paper43.pdf

Semenets-Orlova, I., Klochko, A., Nestulya, S., Mykhailych, O., & Omelyanenko, V. (2019b). Readiness of the education manager to provide the organizational development of institutions (based on the sociological research). Problems and Perspectives in Management, 17 (3), 132-142.

Shenoi, N. C., & Yurewicz, M. (2023). Co-occurring Psychiatric and Substance Use Disorders. Pharmacotherapy for Complex Substance Use Disorders: A Practical Guide, 199.

Sideraki, A., & Drigas, A. (2024). GABA and Executive functions in ASD. Scientific Electronic Archives, 17(3).

Skottun, G., & Krüger, Å. (2021). Gestalt therapy practice: Theory and experiential learning. Routledge.

Smolkin, N. (2018). The relationship between boredom and relapse in substance use disorder recovery. The Wright Institute.

Staff, J., Schulenberg, J. E., Maslowsky, J., Bachman, J. G., O'Malley, P. M., Maggs, J. L., & Johnston, L. D. (2010). Substance use changes and social role transitions: Proximal developmental effects on ongoing trajectories from late adolescence through early adulthood. Development and psychopathology, 22(4), 917-932.

Stokes, A. L. (2023). Cognitive Behavioral Therapy and Addiction Disorders: A Study of Effectiveness of Digital Mental Health Interventions. Doctoral dissertation, Liberty University.

Strang, J., Volkow, N. D., Degenhardt, L., Hickman, M., Johnson, K., Koob, G. F., Marshall, B.D.L., Tyndall, M., & Walsh, S. L. (2020). Opioid use disorder. Nature reviews Disease primers, 6(1), 3.

Stryhul, M., Khomeriki, O., Yahodzinskyi, S., Lyasota, L., & Semenets-Orlova, I.(2019). Peculiarities of development and dynamics of economism and the commercialization of Ukrainian higher education. Problems and Perspectives in Management, 17(2), 289-302. doi:10.21511/ppm.17(2).2019.22

Sung, M., Erkanli, A., Angold, A., & Costello, E. J. (2004). Effects of age at first substance use and psychiatric comorbidity on the development of substance use disorders. Drug and alcohol dependence, 75(3), 287-299.

Taipale, J. (2017). Controlling the uncontrollable. Self-regulation and the dynamics of addiction. The Scandinavian Psychoanalytic Review, 40(1), 29-42.

Tan, J., Altice, F. L., Madden, L. M., & Zelenev, A. (2020). Effect of expanding opioid agonist therapies on the HIV epidemic and mortality in Ukraine: a modelling study. The Lancet HIV, 7(2), e121-e128.

Taylor, M. (2021). Deepening Trauma Practice: A Gestalt Approach to Ecology and Ethics. McGraw-Hill Education (UK).

Trucco, E. M. (2020). A review of psychosocial factors linked to adolescent substance use. Pharmacology Biochemistry and Behavior, 196, 172969.

Vallersnes, O. M., Jacobsen, D., Ekeberg, Ø., & Brekke, M. (2019). Mortality, morbidity and follow-up after acute poisoning by substances of abuse: A prospective observational cohort study. Scandinavian journal of public health, 47(4), 452-461.

Verdejo-Garcia, A., & Albein-Urios, N. (2021). Impulsivity traits and neurocognitive mechanisms conferring vulnerability to substance use disorders. Neuropharmacology, 183, 108402.

Volkow, N. D., & Blanco, C. (2023). Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention. World Psychiatry, 22(2), 203-229.

Wang, Y., Min, J., Khuri, J., Xue, H., Xie, B., Kaminsky, L. A., & Cheskin, L. J. (2020). Effectiveness of mobile health interventions on diabetes and obesity treatment and management: systematic review of systematic reviews. JMIR mHealth and uHealth, 8(4), e15400.

Watson, A. L., Dalila, N., Gomez, J., Mayer, G. H., Patrick, S. W., & Brubaker, M. D. (2015). Counseling in Context: Chemical Dependency and Substance Abuse Programs. Understanding People in Context: The Ecological Perspective in Counseling, 229-258.

Wei, Z. X., Wu, Q., Liu, Q. S., & Cheng, Y. (2020). Neurotransmitter system aberrations in patients with drug addiction. Journal of Neural Transmission, 127, 1641-1650.

Weiss, N. H., Kiefer, R., Goncharenko, S., Raudales, A. M., Forkus, S. R., Schick, M. R., & Contractor, A. A. (2022). Emotion regulation and substance use: a meta-analysis. Drug and alcohol dependence, 230, 109131.

West, R., & Brown, J. (2013). Theory of addiction. John Wiley & Sons, 288.

Wood, M. D., Read, J. P., Mitchell, R. E., & Brand, N. H. (2004). Do parents still matter? Parent and peer influences on alcohol involvement among recent high school graduates. Psychology of addictive behaviors, 18(1), 19.

World Health Organization. (2022). Consolidated guidelines on HIV, viral hepatitis and STI prevention, diagnosis, treatment and care for key populations. World Health Organization.

Wright, L. (2008). Twins: And what they tell us about who we are. Turner Publishing Company.

Yudenko, O. V. & Stepanenko, D. O. (2022). Vascular accidents in military personnel as a result of combat operations: The use of physical therapy. In the International scientific conference “Development of physical culture and sports amidst martial law”: Conference proceedings. Section: Human Health, Fitness and Recreation, Physical Education of Various Population Groups, Physical Rehabilitation (pp. 127-132), October 5–6, 2022. Czestochowa, Republic of Poland: Baltija Publishing. https://doi.org/10.30525/978-9934-26-253-1-31

Zahir, I. I. (2016). Hippocrates: philosophy and medicine. European Scientific Journal, 12(26).

Zefferino, R., Di Gioia, S., & Conese, M. (2021). Molecular links between endocrine, nervous and immune system during chronic stress. Brain and behavior, 11(2), e01960.

Zhylin, M., Makarenko, S., Kolohryvova, N., Bursa, A., & Tsekhmister, Y. (2022). Risk factors for depressive disorders after coming through COVID-19 and emotional intelligence of the individual. Journal of Intellectual Disability-Diagnosis and Treatment, 10(5), 248-258.

Zhylin, M., Malysh, V., Mendelo, V., Potapiuk, L., & Halahan, V. (2024). The impact of emotional intelligence on coping strategies for psychological trauma. Environment and Social Psychology, 9(7).

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