Integrative Biomedical Research | Online ISSN  2207-872X
REVIEWS   (Open Access)

Comprehensive Management of Hemorrhage in Emergency Medicine: Etiology, Diagnosis, and Evidence-Based Interventions

Ibrahim Hussain A Alanazi 1*, Bandar Zaben Alharbi 1, Magliah Rami Fawzi 1, Ibrahim Muhammad Al-Arej 1, Mohammed Raja' Alharithi 1, Mohammed Ibraheem Alshalan 1, Saad Alwan Alshehri 1, Al Duheem, Bader Sughayir D 1, Faisal Nasser S, Alharbi 1, Yousef Sulaiman Alharbi 1, Muteb Majed Fahad Albaqami 1, Hayel Salem Alonazi 1, Alanoud Nasser Alsubaie 1

+ Author Affiliations

Journal of Angiotherapy 8(1) 1-8 https://doi.org/10.25163/angiotherapy.8110226

Submitted: 06 November 2023  Revised: 11 January 2024  Published: 14 January 2024 

Abstract

Background: Hemorrhage remains a leading cause of preventable mortality in emergency medicine, particularly in trauma settings where it accounts for nearly 40% of trauma-related deaths. The condition presents across a spectrum of severity, from minor capillary bleeding to life-threatening vascular injuries, with outcomes heavily dependent on timely recognition and intervention. This review examines current strategies for hemorrhage management in emergency practice, focusing on etiology, diagnostic approaches, and evidence-based treatment protocols to optimize patient outcomes. Methods: A comprehensive analysis of peer-reviewed literature was conducted, incorporating clinical guidelines and recent studies on hemorrhage classification, pathophysiology, and interprofessional management. Emphasis was placed on anatomic-specific bleeding patterns, resuscitation strategies, and complications. Results: Key findings include: (1) Hemorrhage manifests differently by anatomic location (intracranial, thoracic, abdominal, retroperitoneal, orthopedic), each requiring tailored diagnostic approaches; (2) The 1:1:1 transfusion ratio (PRBCs:FFP:platelets) demonstrates superior outcomes in major hemorrhage; (3) Early tranexamic acid administration reduces mortality in traumatic bleeding; (4) Interprofessional team management improves survival rates. Diagnostic imaging selection (CT, FAST, angiography) must balance urgency with accuracy, while hemodynamic targets vary by hemorrhage type (MAP >65 mmHg for general cases, SBP >120 mmHg for TBI). Conclusion: Effective hemorrhage control requires rapid anatomic localization, damage control resuscitation, and interdisciplinary coordination. Standardized protocols and team training significantly improve outcomes in this time-critical condition.

Keywords: hemorrhage control, trauma resuscitation, hemorrhagic shock, transfusion protocols, interprofessional management

References

Aboudara, M., & Maldonado, F. (2019). Update in the management of pleural effusions. Medical Clinics of North America, 103(3), 475–485.

Agarwal, S., Zhou, T., & Frontera, J. (2019). Journal Club: Association between aspirin dose and subarachnoid hemorrhage from saccular aneurysms: A case-control study. Neurology, 92(19), 920–922.

Baekgaard, J. S., Eskesen, T. G., Lee, J. M., Yeh, D. D., Kaafarani, H. M. A., Fagenholz, P. J., Avery, L., Saillant, N., King, D. R., & Velmahos, G. C. (2019). Spontaneous retroperitoneal and rectus sheath hemorrhage—Management, risk factors, and outcomes. World Journal of Surgery, 43(8), 1890–1897.

Carmichael, H., Steward, L., Peltz, E. D., Wright, F. L., & Velopulos, C. G. (2019). Preventable death and interpersonal violence in the United States: Who can be saved? Journal of Trauma and Acute Care Surgery, 87(1), 200–204.

Dhakal, P., Wang, L., Gardiner, J., Shrotriya, S., Sharma, M., & Rayamajhi, S. (2019). Effectiveness of sequential compression devices in prevention of venous thromboembolism in medically ill hospitalized patients: A retrospective cohort study. Turkish Journal of Haematology, 36(3), 193–198.

Foucher, C. D., & Tubben, R. E. (2023). Lactic acidosis. In StatPearls [Internet]. StatPearls Publishing.

Gross, B. A., Jankowitz, B. T., & Friedlander, R. M. (2019). Cerebral intraparenchymal hemorrhage: A review. JAMA, 321(13), 1295–1303.

Hegvik, J. R., Spilman, S. K., Olson, S. D., Gilchrist, C. A., & Sidwell, R. A. (2017). Effective hospital-wide education in hemorrhage control. Journal of the American College of Surgeons, 224(5), 796–799.e1.

Johnson, A. B., & Burns, B. (2023). Hemorrhage. In StatPearls [Internet]. StatPearls Publishing.

Kauvar, D. S., Lefering, R., & Wade, C. E. (2006). Impact of hemorrhage on trauma outcome: An overview of epidemiology, clinical presentations, and therapeutic considerations. Journal of Trauma, 60(6 Suppl), S3–S11.

Kim, D. S., Kong, M. H., Jang, S. Y., Kim, J. H., Kang, D. S., & Song, K. Y. (2013). The usefulness of brain magnetic resonance imaging with mild head injury and the negative findings of brain computed tomography. Journal of Korean Neurosurgical Society, 54(2), 100–106.

Lazarev, A., Golokhvast, K., & Borozda, I. (2019). Review of the problems of diagnosis of endopelvic haemorrhage, its intensity, volume, and duration, and treatment methods of circulatory injuries and surgical hemostasis after pelvic fractures. Emergency Medicine International, 2019, 2514146.

Lee, S. U., Kim, T., Kwon, O. K., Bang, J. S., Ban, S. P., Byoun, H. S., & Oh, C. W. (2020). Trends in the incidence and treatment of cerebrovascular diseases in Korea: Part I. Intracranial aneurysm, intracerebral hemorrhage, and arteriovenous malformation. Journal of Korean Neurosurgical Society, 63(1), 56–68.

Mackenzie, M. J., Hiranandani, R., Wang, D., Fung, T., & Lang, E. (2017). Determinants of computed tomography head scan ordering for patients with low-risk headache in the emergency department. Cureus, 9(10), e1760.

Matano, F., Fujiki, Y., Mizunari, T., Koketsu, K., Tamaki, T., Murai, Y., Yokota, H., & Morita, A. (2019). Serum glucose and potassium ratio as risk factors for cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Journal of Stroke and Cerebrovascular Diseases, 28(7), 1951–1957.

Nixon, G., Blattner, K., Muirhead, J., Finnie, W., Lawrenson, R., & Kerse, N. (2018). Scope of point-of-care ultrasound practice in rural New Zealand. Journal of Primary Health Care, 10(3), 224–236.

Palmer, L. (2017). Fluid management in patients with trauma: Restrictive versus liberal approach. Veterinary Clinics of North America: Small Animal Practice, 47(2), 397–410.

Pontius, E., & Vieth, J. T. (2019). Complications in early pregnancy. Emergency Medicine Clinics of North America, 37(2), 219–237.

Rubano, E., Mehta, N., Caputo, W., Paladino, L., & Sinert, R. (2013). Systematic review: Emergency department bedside ultrasonography for diagnosing suspected abdominal aortic aneurysm. Academic Emergency Medicine, 20(2), 128–138.

Vulliamy, P., Thaventhiran, A. J., & Davenport, R. A. (2019). What's new for trauma haemorrhage management? British Journal of Hospital Medicine (London), 80(5), 268–273.

PDF
Full Text
Export Citation

View Dimensions


View Plumx



View Altmetric



41
Save
0
Citation
275
View
1
Share