EMAN RESEARCH PUBLISHING | <p>Evaluation of Safety and Efficacy of Labeesity<sup>®</sup> for Weight Management and Fatigue in an Obese Female Patient with Hypothyroidism: A Case Report</p>
Inflammation Cancer Angiogenesis Biology and Therapeutics | Impact 0.1 (CiteScore) | Online ISSN  2207-872X
CASE STUDY   (Open Access)

Evaluation of Safety and Efficacy of Labeesity® for Weight Management and Fatigue in an Obese Female Patient with Hypothyroidism: A Case Report

Aman Shah Abdul MajidA*, Elham FarsiB, Natesan VijayalakshmiC, Syarifah Aisya Syed AmranD, Mahibub Mahadmadsa KanakalE, Zarina Thasneem ZainudeenF*

+ Author Affiliations

Journal of Angiotherapy 3(1) 132-137 https://doi.org/10.25163/angiotherapy.31206861406240619

Submitted: 14 May 2019  Revised: 17 June 2019  Published: 24 June 2019 


In this study, we aimed to evaluate the efficacy and safety administration of Labeesity® 125mg, an anti-obesity natural product supplement available in the market. A clinical obese female with medication-controlled hypothyroidism volunteered for this trial. The patient was supplemented with Labeesity® 125mg twice daily for 40 days. The hematological, serum biochemical, subject characteristic were recorded before and after treatment. When compared with the baseline reading, the treatment was favorable for weight loss, with hip and waist circumference reduction. It also improved the patient’s general quality of life over the course of 40 days. There was no treatment related negative clinical symptoms except for mild bloating which dissipated after the second week of supplementation. Furthermore, there were no significant hematological and biochemical alterations, except for a slight fluctuation in uric acid. Labeesity® 125mg intake for the volunteer is assumed to be generally safe with moderate improvement in weight reduction, body composition and serum lipid profile. Longer period of observations on the effects of Labeesity® 125mg would be required to evaluate if the positive effects seen would persist beyond 40 days of intervention. Therefore, strong evidence to support the potential effectiveness and long-term benefits of Labisia pumila extracts based products will require robust studies to be conducted utilizing larger patient numbers and over extended periods of time to rule out any potential toxic effects.

Key words: Labisia pumila, Labeesity®, Safety, Efficacy, Anti-obesity


Al-Wahaibi, A., Wan Nazaimoon, W. M., Norsyam, W. N., Farihah, H. S., & Azian, A. L. (2008). Effect of water extract of Labisia pumila Var Alata on aorta of ovariectomized Sprague Dawley rats. Pakistan Journal of Nutrition. https://doi.org/10.3923/pjn.2008.208.213

Annie, G., Dale, W., Azreena, A., & Malkanthi, E. (2014). Safety and efficacy of a Labisia pumila var alata water extract on sexual well being and lipid profile of pre- and postmenopausal women: A randomized double-blind pilot study. African Journal of Biotechnology. https://doi.org/10.5897/ajb2013.13457

Avula, B., Wang, Y. H., Ali, Z., Smillie, T. J., & Khan, I. A. (2011). Quantitative determination of triperpene saponins and alkenated-phenolics from labisia pumila using an LC-UV/ELSD method and confirmation by LC-ESI-TOF. Planta Medica. https://doi.org/10.1055/s-0030-1271037

Azarbad, L., & Gonder-Frederick, L. (2010). Obesity in Women. Psychiatric Clinics of North America. https://doi.org/10.1016/j.psc.2010.01.003

Bråkenhielm, E., Cao, R., Gao, B., Angelin, B., Cannon, B., Parini, P., & Cao, Y. (2004). Angiogenesis inhibitor, TNP-470, prevents diet induced and genetic obesity in mice. Circulation Research. https://doi.org/10.1161/01.RES.0000132745.76882.70

Cao, Y. (2007). Angiogenesis modulates adipogenesis and obesity. Journal of Clinical Investigation. https://doi.org/10.1172/JCI32239

Choi, H. kyung, Kim, D. hyun, Kim, J. W., Ngadiran, S., Sarmidi, M. R., & Park, C. S. (2010). Labisia pumila extract protects skin cells from photoaging caused by UVB irradiation. Journal of Bioscience and Bioengineering. https://doi.org/10.1016/j.jbiosc.2009.08.478

Chua, L. S., Lee, S. Y., Abdullah, N., & Sarmidi, M. R. (2012). Review on Labisia pumila (Kacip Fatimah): Bioactive phytochemicals and skin collagen synthesis promoting herb. Fitoterapia. https://doi.org/10.1016/j.fitote.2012.04.002

D’Eon, T. M., Sharoff, C., Chipkin, S. R., Grow, D., Ruby, B. C., & Braun, B. (2015). Regulation of exercise carbohydrate metabolism by estrogen and progesterone in women. American Journal of Physiology-Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.00271.2002

De Kleijn, M. J. J., van der Schouw, Y. T., Wilson, P. W. F., Grobbee, D. E., & Jacques, P. F. (2002).

Dietary intake of phytoestrogens is associated with a favorable metabolic cardiovascular risk profile in postmenopausal U.S.women: the Framingham study. The Journal of Nutrition. https://doi.org/10.1093/jn/132.2.276

Dianita, R., Jantan, I., Amran, A. Z., & Jalil, J. (2015). Protective effects of Labisia pumila var. alata on biochemical and histopathological alterations of cardiac muscle cells in isoproterenol-induced myocardial infarction rats. Molecules. https://doi.org/10.3390/molecules20034746

Dianita, R., Jantan, I., Jalil, J., & Amran, A. Z. (2016). Effects of Labisia pumila var alata extracts on the lipid profile, serum antioxidant status and abdominal aorta of high-cholesterol diet rats. Phytomedicine. https://doi.org/10.1016/j.phymed.2016.04.004

Effendy, A. W. M., Siti-Nurtahirah, J., & Hussin, Z. M. (2006). The side effects of Kacip Fatimah extract on liver and kidney of white rats. Journal of Sustainability Science and Management, 1, 40–46.

Ezumi, M. F. W., Siti Amrah, S., Suhaimi, A. W. M., & Mohsin, S. S. J. (2007). Evaluation of the female reproductive toxicity of aqueous extract of Labisia pumila var . alata in rats. Indian J Pharmacol. https://doi.org/10.4103/0253-7613.30760

Fadlina Chany Saputri. (2011). Effects of selected medicinal plants on human low-density lipoprotein oxidation, 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radicals and human platelet aggregation. Journal of Medicinal Plants Research. https://doi.org/10.5897/jmpr11.1114

Fazliana, M., Ramos, N. L., Lüthje, P., Sekikubo, M., Holm, Å., Wan Nazaimoon, W. M., & Brauner, A. (2011). Labisia pumila var. alata reduces bacterial load by inducing uroepithelial cell apoptosis. Journal of Ethnopharmacology. https://doi.org/10.1016/j.jep.2011.04.018

Fuad, W., Sulaiman, S., & Islam, M. (2005). EVALUATION OF THE TERATOGENICITY OF AQUEOUS EXTRACT OF Labisia pumila var. alata IN RAT. Malaysian Journal Of.

He, Z., Chen, A. Y., Rojanasakul, Y., Rankin, G. O., & Chen, Y. C. (2016). Gallic acid, a phenolic compound, exerts anti-angiogenic effects via the PTEN/AKT/HIF-1α/VEGF signaling pathway in ovarian cancer cells. Oncology Reports. https://doi.org/10.3892/or.2015.4354

Ibrahim, M. H., & Jaafar, H. Z. E. (2011). The relationship of nitrogen and C/N ratio with secondary metabolites levels and antioxidant activities in three varieties of malaysian kacip fatimah (Labisia pumila Blume). Molecules. https://doi.org/10.3390/molecules16075514

Ibrahim, M. H., Jaafar, H. Z. E., Karimi, E., & Ghasemzadeh, A. (2012). Primary, secondary metabolites, photosynthetic capacity and antioxidant activity of the Malaysian Herb Kacip Fatimah (Labisia pumila Benth) exposed to potassium fertilization under greenhouse conditions. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms131115321

Jaafar, H. Z. E., Ibrahim, M. H., & Karimi, E. (2012). Phenolics and flavonoids compounds, phenylanine ammonia lyase and antioxidant activity responses to elevated CO 2 in Labisia pumila (Myrisinaceae). Molecules. https://doi.org/10.3390/molecules17066348

Jung, U. J., & Choi, M. S. (2014). Obesity and its metabolic complications: The role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms15046184

Karimi, E., & Jaafar, H. Z. E. (2011). HPLC and GC-MS determination of bioactive compounds in microwave obtained extracts of three varieties of labisia pumila benth. Molecules. https://doi.org/10.3390/molecules16086791

Karimi, E., Jaafar, H. Z. E., & Ahmad, S. (2011). Phytochemical analysis and antimicrobial activities of methanolic extracts of leaf, stem and root from different varieties of labisa pumila benth. Molecules. https://doi.org/10.3390/molecules16064438

Karimi, E., Jaafar, H. Z. E., & Ghtrialadeh, A. (2016). Chemical composition, antioxidant and anticancer potential of Labisia pumila variety alata under CO2 enrichment. NJAS - Wageningen Journal of Life Sciences. https://doi.org/10.1016/j.njas.2016.05.002

Karimi, E., Ze Jaafar, H., Ghasemzadeh, A., & Ebrahimi, M. (2015). Fatty acid composition, antioxidant and antibacterial properties of the microwave aqueous extract of three varieties of Labisia pumila Benth. Biological Research. https://doi.org/10.1186/0717-6287-48-9

Kornstein, S. G., & Clayton, A. H. (2010). Advances in Women’s Mental Health. Psychiatric Clinics of

North America. https://doi.org/10.1016/j.psc.2010.02.002

Kour, K., Sharma, N., Chandan, B. K., Koul, S., Sangwan, P. L., & Bani, S. (2010). Protective effect of Labisia pumila on stress-induced behavioral, biochemical, and immunological alterations. Planta Medica. https://doi.org/10.1055/s-0029-1240953

Manda, V. K., Dale, O. R., Awortwe, C., Ali, Z., Khan, I. A., Walker, L. A., & Khan, S. I. (2014). Evaluation of drug interaction potential of Labisia pumila (Kacip Fatimah) and its constituents. Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2014.00178

Mannerås, L., Fazliana, M., Wan Nazaimoon, W. M., Lönn, M., Gu, H. F., Östenson, C. G., & Stener- Victorin, E. (2010). Beneficial metabolic effects of the Malaysian herb Labisia pumila var. alata in a rat model of polycystic ovary syndrome. Journal of Ethnopharmacology. https://doi.org/10.1016/j.jep.2009.10.032

Norhaiza, M., Maziah, M., & Hakiman, M. (2009). Antioxidative properties of leaf extracts of a popular Malaysian herb, Labisia pumila. Journal of Medicinal Plants Research.

Nurdiana, N., Mariati, N., Noorhamdani, N., Setiawan, B., Budhiparama, N., & Noor, Z. (2016). Effects of Labisia pumila on oxidative stress in rat model of post-menopausal osteoporosis. Asian Pacific Journal of Reproduction. https://doi.org/10.1016/j.apjr.2016.07.015

Okamura, S., Sawada, Y., Satoh, T., Sakamoto, H., Saito, Y., Sumino, H., … Sakamaki, T. (2008). Pueraria Mirifica Phytoestrogens Improve Dyslipidemia in Postmenopausal Women Probably by Activating Estrogen Receptor Subtypes. The Tohoku Journal of Experimental Medicine. https://doi.org/10.1620/tjem.216.341

Pan, Y., Tiong, K. H., Abd-Rashid, B. A., Ismail, Z., Ismail, R., Mak, J. W., & Ong, C. E. (2012). Inhibitory effects of cytochrome P450 enzymes CYP2C8, CYP2C9, CYP2C19 and CYP3A4 by Labisia pumila extracts. Journal of Ethnopharmacology. https://doi.org/10.1016/j.jep.2012.07.024 

Pandey, A. (2014). Anti-Obesity Potential of Gallic Acid from Labisia pumila, through Augmentation of Adipokines in High Fat Diet Induced Obesity in C57BL/6 Mice. Advances in Research. https://doi.org/10.9734/air/2014/10182

Pandey, A., Bani, S., Sangwan, P., & Koul, S. (2010). Selective Th1 upregulation by ethyl acetate fraction of Labisia pumila. Journal of Ethnopharmacology. https://doi.org/10.1016/j.jep.2010.08.039

Sah, S. P., Singh, B., Choudhary, S., & Kumar, A. (2016). Animal models of insulin resistance: A review. Pharmacological Reports. https://doi.org/10.1016/j.pharep.2016.07.010

Samad, Nozlena. (2018). Labisia Pumila -- A Source of Medicine. Australian Herbal Insight, 1(2), pages 4–6. https://doi.org/10.25163/ahi.110002

Sanusi, R. A. M., Ab Shukor, N. A., & Sulaiman, M. R. (2013). Anti-inflammatory effects of Labisia pumila (Blume) F. Vill-Naves. aqueous extract. Sains Malaysiana.

Sorensen, T. I., Echwald, S. M., & Holm, J.-C. (2011). Leptin in obesity. BMJ. https://doi.org/10.1136/bmj.313.7063.953

Suan Chua, L., Abdul Latiff, N., Yean Lee, S., Tin Lee, C., Roji Sarmidi, M., & Abdul Aziz, R. (2011). Flavonoids and phenolic acids from Labisia pumila (Kacip Fatimah). Food Chemistry. https://doi.org/10.1016/j.foodchem.2011.01.122

Taxvig, C., Specht, I. O., Boberg, J., Vinggaard, A. M., & Nellemann, C. (2013). Dietary relevant mixtures of phytoestrogens inhibit adipocyte differentiation in vitro. Food and Chemical Toxicology. https://doi.org/10.1016/j.fct.2012.12.060

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