Programmable DNA binding oligomers for control of transpcription in angiogenesis

Sarah Furkan

doi:10.25163/angiotherapy.11000721108100517

Volume 1 Number 1 2017

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Programmable DNA binding oligomers for control of transpcription in angiogenesis

Abstract Introduction DNA Binding Polyamides Synthesis of DNA-Binding Polyamides Antiangiogenic oligomers References

Sarah Furkan

+ Author Affiliations

Journal of Angiotherapy 1 (1) 033-035 https://doi.org/10.25163/angiotherapy.11000721108100517

Submitted: 11 September 2016 Revised: 16 February 2017 Published: 10 May 2017

Abstract

The drug discovery opportunities with chemistry, biology and human medicine are increasing by mapping and sequencing the genetic blueprint of humans, mice and other organisms. The realization of the function of 25,000 genes of humans and understanding the biological circles that control these genes will be a crucial starting point for new chemistry technologies. The cellular events that lead to cancer and diseases in human involve aberrant gene expression. Small molecules that can be programmed to mimic transcription factors could be useful tools in biology and potentially in human medicine as they could bind a large repertoire of DNA sequences in the human genome.

Keywords: Transcription, Oligomers, DNA, Chromatin, Drug Discovery, Angiogenesis

References

Dervan, P. B., et al. (2005). "Programmable DNA binding oligomers for control of transcription." Current Medicinal Chemistry-Anti-Cancer Agents, 5(4), 373-387.

Fallows, A. J., et al. (2014). "Highly efficient synthesis of DNA-binding polyamides using a convergent fragment-based approach." Organic letters, 16(17), 4654-4657.

Koeller, K. J., et al. (2014). "DNA binding polyamides and the importance of DNA recognition in their use as gene-specific and antiviral agents." Medicinal chemistry, 4, 338.

Olenyuk, B. Z., et al. (2004). "Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist." Proceedings of the National Academy of Sciences of the United States of America, 101(48), 16768-16773.

Integrative Biomedical Research

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Programmable DNA binding oligomers for control of transpcription in angiogenesis

Abstract

References

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